Results 121 to 130 of about 133,982 (304)
International Journal for Parasitology: Parasites and Wildlife, 2019 Molecular phylogenetic studies have revealed the growing diversity of bat trypanosomes. Here, 14 isolates from blood samples of the vampire bat Desmodus rotundus (Phyllostomidae) from Rio de Janeiro, Southeast Brazil, were cultivated, and morphologically
Juliana H.S. Barros +3 more
doaj
mBio, 2015 Trypanosoma cruzi is the etiologic agent of Chagas disease, and current methods for its genetic manipulation have been highly inefficient. We report here the use of the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR ...
N. Lander +3 more
semanticscholar +1 more source
Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development
ChemBioChem, Volume 26, Issue 7, April 1, 2025.Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen +8 more
wiley +1 more source
Expert Review of Anti-Infective Therapy, 2015 Over the last 30 years, concomitant with successful transnational disease control programs across Latin America, Chagas disease has expanded from a neglected, endemic parasitic infection of the rural poor to an urbanized chronic disease, and now a ...
L. Messenger, M. Miles, C. Bern
semanticscholar +1 more source
Revista da Sociedade Brasileira de Medicina Tropical, 2011 INTRODUCTION: For a long time, the importance of Chagas disease in Mexico, where many regarded it as an exotic malady, was questioned. Considering the great genetic diversity among isolates of Trypanosoma cruzi, the importance of this biological ...
César Gómez-Hernández +8 more
doaj
Revista da Sociedade Brasileira de Medicina Tropical, 2008 Seven individuals living in a town in the Southwest of Bahia developed sudden signs of cardiac and systemic impairment, with lethality of 28.6%. Serological tests were positive at least in one test in the five patients examined.
Juarez Pereira Dias +11 more
doaj +1 more source
Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection? [PDF]
, 2016 Indexación: Web of Science.Background: For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T.
A Colombo +42 more
core +1 more source
Bed Bugs (Cimex lectularius) as Vectors of Trypanosoma cruzi
American Journal of Tropical Medicine and Hygiene, 2015 Populations of the common bed bug, Cimex lectularius, have recently undergone explosive growth. Bed bugs share many important traits with triatomine insects, but it remains unclear whether these similarities include the ability to transmit Trypanosoma ...
Renzo Salazar +5 more
semanticscholar +1 more source
Development of Antisense Tools to Study Bodo saltans and Its Intracellular Symbiont
MicrobiologyOpen, Volume 14, Issue 2, April 2025.Obligate symbioses present challenges for functional genetic analysis. This study shows that antisense inhibition cannot be used to investigate gene functions in the aquatic symbiosis between Bodo saltans and its bacterial symbiont. Our work stresses the importance of the development of alternative protocols to study the biology of both the ...
Mastaneh Ahrar +6 more
wiley +1 more source
Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model [PDF]
, 2016 Chronic obesity and Chagas disease (caused by the protozoan Trypanosoma cruzi) represent serious public health concerns. The interrelation between parasite infection, adipose tissue, immune system and metabolism in an obesogenic context, has not been ...
Andrada, Marta Cecilia +8 more
core +4 more sources