Histopathologic identification of Trypanosoma cruzi (Chagas') encephalitis in an AIDS patient
Human Pathology: Case Reports, 2017 Trypanosoma cruzi (Chagas') encephalitis is an uncommon manifestation of T. cruzi infection, typically seen in immunocompromised patients. Encephalitis results from the reactivation of chronic infection predominately in individuals from endemic areas ...
Dimath Alyemni +8 more
doaj
The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America [PDF]
, 2018 It is estimated that between 8000 and 15 000 Trypanosoma cruzi infected babies are born every year to infected mothers in Chagas disease endemic countries. Currently, poor access to and performance of the current diagnostic algorithm, based on microscopy
Cruz, Israel +7 more
core +1 more source
Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery
PLoS Neglected Tropical Diseases, 2015 Background Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is extremely sparse and lacks drug target diversity.
S. Ekins +12 more
semanticscholar +1 more source
Parasite Spreading in Spatial Ecological Multiplex Networks [PDF]
arXiv, 2016 Network ecology is a rising field of quantitative biology representing ecosystems as complex networks. A suitable example is parasite spreading: several parasites may be transmitted among their hosts through different mechanisms, each one giving rise to a network of interactions.
arxiv
Repurposing of terconazole as an anti Trypanosoma cruzi agent [PDF]
, 2019 Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. Currently there are no effective treatments for the chronic phase of the disease, when most patients are diagnosed, therefore the development of ...
Martínez Sayé, Melisa Soledad +4 more
core +1 more source
Trypanosoma cruzi and Its Soluble Antigens Induce NET Release by Stimulating Toll-Like Receptors
PLoS ONE, 2015 Neutrophils release fibrous traps of DNA, histones, and granule proteins known as neutrophil extracellular traps (NETs), which contribute to microbicidal killing and have been implicated in autoimmunity.
Daniel Sousa-Rocha +5 more
semanticscholar +1 more source
Recherches sur le cycle évolutif de Trypanosoma cruzi chagas a propos de l’infestation péritonéale exclusive chez la souris [PDF]
, 1952 H. Gálliard
openalex +1 more source
Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition [PDF]
, 2014 CYP51 (sterol 14α-demethylase) is an efficient target for clinical and agricultural antifungals and an emerging target for treatment of Chagas disease, the infection that is caused by multiple strains of a protozoan pathogen Trypanosoma cruzi.
Cherkesova, Tatiana S. +6 more
core +1 more source
The trans-sialidase, the major Trypanosoma cruzi virulence factor: Three decades of studies.
Glycobiology, 2015 Chagas' disease is a potentially life-threatening disease caused by the protozoan parasite Trypanosoma cruzi. Since the description of Chagas'disease in 1909 extensive research has identified important events in the disease in order to understand the ...
L. Freire-de-Lima +4 more
semanticscholar +1 more source
Edelfosine (ET-18-OCH3) a Promising Alkylphospholipid against Resistant Trichomonas vaginalis
Proceedings, 2017 Edelfosine (ET-18-OCH3) is an alkylphospholipid with an analogous structure to miltefosine. Both molecules are active against kinetoplastids (Leishmania spp., Trypanosoma cruzi and Trypanosoma brucei). [...]
Alexandra Ibáñez-Escribano +3 more
doaj +1 more source