Results 141 to 150 of about 143,738 (310)

Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. [PDF]

, 2010
Oxidative stress is common in inflammatory processes associated with many diseases including Chagas' disease. The aim of the present study was to evaluate, in a murine model, biomarkers of oxidative stress together with components of the antioxidant ...
Arantes, Jerusa Marilda, Araújo, Márcio Sobreira Silva, Carneiro, Cláudia Martins, de Abreu Vieira, Paula Melo, Elói-Santos, Silvana Maria, Francisco, Amanda Fortes, Martins-Filho, Olindo Assis, Pedrosa, Maria Lúcia, Silva, Maisa, Tafuri, Washington Luiz, Teixeira-Carvalho, Andréa   +10 more
core   +2 more sources

Effects of TcFLA‐1BP and TcGP72 Deletion on the Infectivity and Survival of Trypanosoma cruzi in Cell Cultures

Cell Biology International, Volume 49, Issue 11, Page 1395-1410, November 2025.
ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease with limited treatment options and no available vaccine. Understanding the role of proteins in the parasite's biological cycle is critical for advancing vaccine development and optimizing therapies.
Normanda Souza‐Melo, Giovanna Henriques de Souza, Wanderley de Souza   +2 more
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

CpG and Interleukin-15 Synergize to Enhance IFN-γ Production by Activated CD8+ T Cells [PDF]

, 2012
Interleukin-15 (IL-15) regulates the development and maintenance of memory CD8+ T cells. Paradoxically, we previously reported that IL-15 could enhance CD8+ T-cell responses to IL-12, a proinflammatory cytokine required for optimal priming of effector ...
Cobb, Dustin, Guo, Siqi, Smeltz, Ronald B.   +2 more
core   +5 more sources

Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes

Cell Biology International, Volume 49, Issue 10, Page 1301-1318, October 2025.
ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio, Ariely Barbosa Leite, Ana Caroline de Castro Nascimento Sousa, Suellen Rodrigues Maran, Antoniel Augusto Severo Gomes, Elton J. R. Vasconcelos, Nilmar Silvio Moretti   +6 more
wiley   +1 more source

Contribuição ao estudo da infecção de morcegos por hemoflagelados do gênero Trypanosoma Gruby, 1843

Cadernos de Saúde Pública, 1991
O presente estudo foi realizado no período de julho de 1983 a dezembro de 1984, nos municípios cearenses de Russas, Palhano, Limoeiro do Norte, Morada Nova, Canindé, Quixadá e Pereiro, os quais correspondem a parte da área endêmica da tripanossomíase ...
Marta E. Fabián
doaj   +1 more source

Recherches sur le cycle évolutif de Trypanosoma cruzi chagas a propos de l’infestation péritonéale exclusive chez la souris [PDF]

, 1952
H. Gálliard
openalex   +1 more source

A New Experimental Model for Assessing Drug Efficacy against Trypanosoma cruzi Infection Based on Highly Sensitive In Vivo Imaging

Journal of biomolecular screening, 2015
The protozoan Trypanosoma cruzi is the causative agent of Chagas disease, one of the world’s major neglected infections. Although development of improved antiparasitic drugs is considered a priority, there have been no significant treatment advances in ...
M. Lewis, A. Francisco, M. Taylor, J. Kelly   +3 more
semanticscholar   +1 more source

Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century. [PDF]

, 2007
In this article, Médicos Sin Fronteras (MSF) Spain faces the challenge of selecting, piecing together, and conveying in the clearest possible way, the main lessons learnt over the course of the last seven years in the world of medical care for Chagas ...
Albajar-Vinas, P, Bernal, O, Bulla, D, Morote, S, Villa, L   +4 more
core   +4 more sources

Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease

Protein Science, Volume 34, Issue 10, October 2025.
Abstract Cruzain (Cz), the major cysteine protease of Trypanosoma cruzi, the etiological agent of Chagas disease, employs Cys25 as its catalytic nucleophile, enabling peptide bond hydrolysis via nucleophilic attack on the carbonyl carbon of substrates.
Clauber H. S. da Costa, Vinícius Bonatto, Hemillin Brenda Teixeira Santos, Carlos Gabriel da Silva de Souza, Carlos A. Montanari, Munir S. Skaf, F. Javier Luque, Jerônimo Lameira   +7 more
wiley   +1 more source