Results 141 to 150 of about 143,738 (310)
Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. [PDF]
Oxidative stress is common in inflammatory processes associated with many diseases including Chagas' disease. The aim of the present study was to evaluate, in a murine model, biomarkers of oxidative stress together with components of the antioxidant ...
Arantes, Jerusa Marilda+10 more
core +2 more sources
ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease with limited treatment options and no available vaccine. Understanding the role of proteins in the parasite's biological cycle is critical for advancing vaccine development and optimizing therapies.
Normanda Souza‐Melo+2 more
wiley +1 more source
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro+5 more
wiley +1 more source
CpG and Interleukin-15 Synergize to Enhance IFN-γ Production by Activated CD8+ T Cells [PDF]
Interleukin-15 (IL-15) regulates the development and maintenance of memory CD8+ T cells. Paradoxically, we previously reported that IL-15 could enhance CD8+ T-cell responses to IL-12, a proinflammatory cytokine required for optimal priming of effector ...
Cobb, Dustin+2 more
core +5 more sources
Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes
ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio+6 more
wiley +1 more source
Contribuição ao estudo da infecção de morcegos por hemoflagelados do gênero Trypanosoma Gruby, 1843
O presente estudo foi realizado no período de julho de 1983 a dezembro de 1984, nos municípios cearenses de Russas, Palhano, Limoeiro do Norte, Morada Nova, Canindé, Quixadá e Pereiro, os quais correspondem a parte da área endêmica da tripanossomíase ...
Marta E. Fabián
doaj +1 more source
Recherches sur le cycle évolutif de Trypanosoma cruzi chagas a propos de l’infestation péritonéale exclusive chez la souris [PDF]
H. Gálliard
openalex +1 more source
The protozoan Trypanosoma cruzi is the causative agent of Chagas disease, one of the world’s major neglected infections. Although development of improved antiparasitic drugs is considered a priority, there have been no significant treatment advances in ...
M. Lewis+3 more
semanticscholar +1 more source
Access to diagnosis and treatment of Chagas disease/infection in endemic and non-endemic countries in the XXI century. [PDF]
In this article, Médicos Sin Fronteras (MSF) Spain faces the challenge of selecting, piecing together, and conveying in the clearest possible way, the main lessons learnt over the course of the last seven years in the world of medical care for Chagas ...
Albajar-Vinas, P+4 more
core +4 more sources
Abstract Cruzain (Cz), the major cysteine protease of Trypanosoma cruzi, the etiological agent of Chagas disease, employs Cys25 as its catalytic nucleophile, enabling peptide bond hydrolysis via nucleophilic attack on the carbonyl carbon of substrates.
Clauber H. S. da Costa+7 more
wiley +1 more source