Results 101 to 110 of about 39,396 (251)
New Phytologist, Volume 246, Issue 3, Page 1096-1112, May 2025.Summary Mixotrophy via phagocytosis can have profound consequences for the survival of marine phytoplankton and the efficiency of carbon transfer in marine systems. Little is known about the cellular mechanisms that underly nutrient acquisition via prey uptake and processing in mixotrophic phytoplankton. We used confocal microscopy, flow cytometry, and
Julie A. Koester +4 more
wiley +1 more source
Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads
BiomoleculesSterol biosynthesis via the mevalonate-isoprenoid pathway produces ergosterol (24β-methyl cholesta-5,7-dienol) necessary for growth in a wide-range of eukaryotic pathogenic organisms in eukaryotes, including the fungi, trypanosomes and amoebae, while ...
W. David Nes +2 more
doaj +1 more source
Onderstepoort Journal of Veterinary Research, 2019 African animal trypanosomosis (AAT) is caused by several species of the genus Trypanosoma, a parasitic protozoan infecting domestic and wild animals. One of the major effects of infection with pathogenic trypanosome is anaemia.
Abdalla A. Latif +2 more
doaj +1 more source
Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator
Biomolecules, 2020 The translocases of the mitochondrial outer and inner membranes, the TOM and TIMs, import hundreds of nucleus-encoded proteins into mitochondria. TOM and TIMs are multi-subunit protein complexes that work in cooperation with other complexes to import ...
Minu Chaudhuri +5 more
doaj +1 more source
Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development
ChemBioChem, Volume 26, Issue 7, April 1, 2025.Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen +8 more
wiley +1 more source
Multiorgan Dysfunction Caused by Travel-associated African Trypanosomiasis
Emerging Infectious Diseases, 2012 We describe a case of multiorgan dysfunction secondary to Trypanosoma brucei rhodesiense infection acquired on safari in Zambia. This case was one of several recently reported to ProMED-mail in persons who had traveled to this region.
Lucy E. Cottle +8 more
doaj +1 more source
Neurobiology of Disease, 2002 Disturbances in biological rhythms pose a major disease problem, not the least in the aging population. Experimental sleeping sickness, caused by Trypanosoma brucei brucei, in rats constitutes a unique and robust chronic model for studying mechanisms of ...
G.B. Lundkvist +2 more
doaj
Comparative clinico-haematological analysis in young Zebu cattle experimentally infected with Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia [PDF]
, 2015 Background: Ethiopia, particularly in the Northwest region, is affected by both tsetse and non-tsetse fly transmitted trypanosomosis, with significant impact on livestock productivity. The aim of this study was to determine and compare clinical findings
Abebe, Getachew +5 more
core +2 more sources
Frontiers in Microbiology, 2014 Tsetse flies (Glossina sp.) that transmit trypanosomes causing human (and animal) African trypanosomiasis (HAT and AAT, respectively) harbor symbiotic microorganisms, including the obligate primary symbiont Wigglesworthia glossinidia.
Illiassou eHamidou Soumana +3 more
doaj +1 more source
Metabolomic systems biology of trypanosomes [PDF]
, 2010 Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental ...
BARBARA M. BAKKER +4 more
core +5 more sources