Results 121 to 130 of about 39,396 (251)

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

open access: yesInternational Journal for Parasitology: Drugs and Drug Resistance
Earlier evidences showed that diglycosyl diselenides are active against the infective stage of African trypanosomes (top hits IC50 0.5 and 1.5 μM) but poorly selective (selectivity index 38-folds vs. murine and human macrohages).
Estefanía Dibello   +9 more
doaj  

Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei

open access: yesJournal of Lipid Research, 2007
Trypanosoma brucei (TB) cultured in rat blood, bovine serum, or lipid-depleted serum generated distinct differences in cholesterol availability. Whereas cell proliferation of the parasite was relatively unaffected by cholesterol availability, the ratios ...
Wenxu Zhou   +2 more
doaj  

The genetics and genomics of Trypanosoma cruzi [PDF]

open access: yes, 2007
Trypanosoma cruzi is a kinetoplastid parasite that causes Chagas disease. Trypanosomes are unusual organisms in many aspects of its genetics and molecular and cellular biology and considered a paradigm of the exception of the rule in the eukaryotic ...
Vazquez, Martin Pablo
core  

Integrated control of vector-borne diseases of livestock--pyrethroids: panacea or poison?

open access: yes, 2003
Tick- and tsetse-borne diseases cost Africa approximately US$4-5 billion per year in livestock production-associated losses. The use of pyrethroid-treated cattle to control ticks and tsetse promises to be an increasingly important tool to counter this ...
Coleman, Paul G   +4 more
core   +1 more source

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