Results 51 to 60 of about 10,118 (210)

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei [PDF]

, 2015
Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
De Koning, Harry P., Munday, Jane C., Settimo, Luca   +2 more
core   +1 more source

Cytotoxicity and Antimicrobial Activity of GaMF1 Analogs

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
GaMF1 is a reported, highly potent inhibitor of mycobacterial ATP synthase. Structural modification of this scaffold significantly changes biological activity. We present GaMF1 analogues with strong antiparasitic effects, potential antiproliferative properties, and discuss the selectivity limitations of the parent compound and its analogues.
Jan Chasák, Petr Vyvlečka, Ivan Nemec, An Matheeussen, Natascha Van Pelt, Paul Cos, Guy Caljon, Vladimír Kryštof, Lucie Brulíková   +8 more
wiley   +1 more source

Spatial Distribution of Tsetse Flies and Trypanosome Infection Status in a Vector Genetic Transition Zone in Northern Uganda

Journal of Parasitology Research, 2022
Background. Tsetse flies are vectors of the genus Trypanosoma that cause African trypanosomiasis, a serious parasitic disease of people and animals. Reliable data on the vector distribution and the trypanosome species they carry is pertinent for planning
Robert Opiro, Okello Allele Moses, Robert Opoke, Francis A. Oloya, Esther Nakafu, Teresa Iwiru, Richard Echodu, Geoffrey M. Malinga, Joel L. Bargul, Elizabeth A. Opiyo   +9 more
doaj   +1 more source

Molecular and phylogenetic analysis of a type K1 strain Trypanosoma evansi isolate from Nigerian cattle: An evaluation of the therapeutic effects of compounds from Brassica oleracea on the histopathology of infected wister rats

Biochemistry and Biophysics Reports, 2023
Background: Understanding the pathogenesis of animal trypanosomiasis can be improved by studying the genetics of bovine trypanosomes. Pathogenic animal trypanosomes are a major impediment to livestock production, with negative economic consequences ...
Kingsley Onyekachi Moh, Sodangi Abdulkarim Luka, Iliya Shehu Ndams, Idris Alao Lawal, Dahiru Sani, Sylvester Sunday Obeta, Gbenga Peter Oderinde, Emeka John Dingwoke, Fatima Amin Adamude, Abraham Ehinomhen Ubhenin, Saifullahi Umar   +10 more
doaj   +1 more source

Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]

, 2016
Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P., Hofer, Anders, Pavlova, Anna, Ranjbarian, Farahnaz, Vodnala, Munender   +4 more
core   +1 more source

Weaving knowledges to support wildlife health surveillance in Kenya's pastoral rangelands

Conservation Biology, Volume 40, Issue 1, February 2026.
Abstract In wildlife–livestock–human interfaces, pathogens capable of spreading between wild and domestic animals and humans have important implications for conservation outcomes, economics, and public health. Robust wildlife health surveillance can help address these risks.
Brock Bersaglio, Charis Enns, Nashipai Karinten, Ramson Karmushu, Susanne Shultz   +4 more
wiley   +1 more source

Control of endemic tropical diseases. Identifying certain animal diseases as "neglected" [PDF]

, 2015
The "neglected" status given by the World Health Organization (WHO) to certain endemic tropical diseases, both human and zoonotic, affecting poor populations has resulted in the large-scale mobilisation of stakeholders and resources, thereby improving ...
Bonnet, Pascal, Roger, François
core   +1 more source

Knowledge, Attitudes and Practices Regarding Livestock Diseases Among Residents of East Gojjam Zone, Amhara Region, Ethiopia

Veterinary Medicine and Science, Volume 12, Issue 1, January 2026.
This study reveals gaps in livestock owners’ knowledge and practices regarding disease prevention and control in East Gojjam Zone, Ethiopia, highlighting the need for strengthened veterinary extension services and community education to improve animal health management.
Liuel Yizengaw, Haregua Yesigat, Kifile Wondimagegnehu, Arega Tafere, Habtamu Yalew, Dessalew Habtie, Natenael Teshager, Yibeltal Simeneh   +7 more
wiley   +1 more source

Integration Analysis of Metabolome and Transcriptome Reveals the Effect of Lipopolysaccharide on Ovary Response to Stimulation

Immunity, Inflammation and Disease, Volume 13, Issue 12, December 2025.
This study provided evidence of inflammation on damaging ovary response to controlled ovarian stimulation, linked to dysfunctions in lipid, carbohydrate, and amino acid metabolism. IL‐17 signal pathways may play a critical role in this process. ABSTRACT Objective This study aimed to elucidate the underlying mechanisms by which lipopolysaccharide (LPS ...
Xin Mu, Feng Zhu, Yudan Zhang, Mei‐Li Pei   +3 more
wiley   +1 more source

Trypanocide usage in the cattle belt of southwestern Uganda

Frontiers in Microbiology, 2023
BackgroundSystematic infrastructure and regulatory weaknesses over many decades, in communities struggling with animal African trypanosomiasis (AAT) would be expected to create an environment that would promote drug misuse and risk development of drug ...
Keneth Iceland Kasozi, Keneth Iceland Kasozi, Ewan Thomas MacLeod, Keith Robert Sones, Keith Robert Sones, Susan Christina Welburn, Susan Christina Welburn   +6 more
doaj   +1 more source