Results 151 to 160 of about 901,103 (252)

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

LEKTI-Grafted Sunflower Trypsin Inhibitor: A Potential Therapeutic for Skin Diseases. [PDF]

J Med Chem
Mah J, Jayarajan V, Huang X, Di WL, Macmillan D.   +4 more
europepmc   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Effect of protein-rich diet and the tamarind trypsin inhibitor on behavioral disorders in obese zebrafish. [PDF]

Front Nutr
Silva AKXG, Medeiros I, Mamede JP, Trajano AC, Costa TIDS, de Sousa ALM, de Souza LAL, Nascimento AMS, da Silva-Maia JK, Morais AHA.   +9 more
europepmc   +1 more source

Prospecting in silico antibacterial activity of a peptide from trypsin inhibitor isolated from tamarind seed. [PDF]

J Enzyme Inhib Med Chem, 2023
Oliveira GS, Nascimento AMS, Luz ABS, Aguiar AJFC, Lima MSR, Matias LLR, Amado IR, Passos TS, Damasceno KSFDSC, Monteiro NKV, Moreira SMG, Pastrana L, Morais AHA.   +12 more
europepmc   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Mechanistic clues from urinary trypsin inhibitor in sepsis research. [PDF]

Cent Eur J Immunol
Poniewierska-Baran A, Niedźwiedzka-Rystwej P, Eljaszewicz A.   +2 more
europepmc   +1 more source

A soybean trypsin inhibitor reduces the resistance to transgenic maize in a population of Spodoptera frugiperda (Lepidoptera: Noctuidae). [PDF]

J Econ Entomol, 2023
Fonseca SS, Santos ALZ, Pinto CPG, Marques L, Santos AC, Bing J, Nowatzki T, Sethi A, Rossi GD.   +8 more
europepmc   +1 more source

Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy

Advanced Science, EarlyView.
A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan, Yuling Xu, Ting Yu, Yang Li, Xin Jiang, Haoyu Jin, Haitao Li, Youyu Zhang, Peng Yin, Jong Seung Kim   +9 more
wiley   +1 more source

Divergent functions of three Kunitz trypsin inhibitor (KTI) proteins in herbivore defense in poplar. [PDF]

BMC Plant Biol
Das IS, Shi Q, Dreischhoff S, Polle A.
europepmc   +1 more source