Results 171 to 180 of about 242,155 (315)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Effect of protein-rich diet and the tamarind trypsin inhibitor on behavioral disorders in obese zebrafish. [PDF]

Front Nutr
Silva AKXG, Medeiros I, Mamede JP, Trajano AC, Costa TIDS, de Sousa ALM, de Souza LAL, Nascimento AMS, da Silva-Maia JK, Morais AHA.   +9 more
europepmc   +1 more source

A soybean trypsin inhibitor reduces the resistance to transgenic maize in a population of Spodoptera frugiperda (Lepidoptera: Noctuidae). [PDF]

J Econ Entomol, 2023
Fonseca SS, Santos ALZ, Pinto CPG, Marques L, Santos AC, Bing J, Nowatzki T, Sethi A, Rossi GD.   +8 more
europepmc   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Divergent functions of three Kunitz trypsin inhibitor (KTI) proteins in herbivore defense in poplar. [PDF]

BMC Plant Biol
Das IS, Shi Q, Dreischhoff S, Polle A.
europepmc   +1 more source

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

Mechanistic clues from urinary trypsin inhibitor in sepsis research. [PDF]

Cent Eur J Immunol
Poniewierska-Baran A, Niedźwiedzka-Rystwej P, Eljaszewicz A.   +2 more
europepmc   +1 more source

Interactions between Soybean Trypsin Inhibitor and Chitosan in an Aqueous Solution. [PDF]

Polymers (Basel), 2023
Zhang Y, Liu R, Li H, Li Y, Liu X.
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Increasing dietary soybean trypsin inhibitor protein attenuates nursery pig performance. [PDF]

Transl Anim Sci
Miller KA, Spencer JD, Krishnan HB, Mendoza OF, McCallum MN, Mahoney JA, Burrough ER, Gabler NK.   +7 more
europepmc   +1 more source