Results 191 to 200 of about 242,155 (315)

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Synthesis and Characterization of a Trypsin Inhibitor

, 1998
Inhibitors of biological enzymes are frequently produced by mimicking the molecular structure of the enzyme\u27s natural substrate. Because of the extensive studies that have already been performed on the trypsin enzyme, its natural substrates and its ...
Schneider, Eric L.
core  

In vitro and molecular modeling insights into α-amylase inhibition by tamarind seed-derived trypsin inhibitor: Implications for hyperglycemic control. [PDF]

PLoS One
de Souza LAL, de Souza Sena CP, de Macêdo Oliveira FC, Serquiz RP, Aguiar AJFC, de Souza Nascimento AM, de Gois Silva AKX, de Paiva Chaves R, Santana Luz AB, Passos TS, Vieira DS, Morais AHA.   +11 more
europepmc   +1 more source

No correlation between amylase/trypsin-inhibitor content and amylase inhibitory activity in hexaploid and tetraploid wheat species. [PDF]

Curr Res Food Sci, 2023
Jahn N, Longin CFH, Scherf KA, Geisslitz S.   +3 more
europepmc   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Effects of Soybean Trypsin Inhibitor on Pancreatic Oxidative Damage of Mice at Different Growth Periods. [PDF]

Foods, 2023
Gu C, Yang Q, Li S, Zhao L, Lyu B, Wang Y, Yu H.   +6 more
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

The Potential for Trypsin Inhibitor Expression in Leaves to Convey Herbivory Deterrence in Soybean. [PDF]

Plants (Basel)
Birdwell AE, Brown SA, D'Angelo GJ, Mazarei M, Stewart CN.   +4 more
europepmc   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Retracted: Evaluation of morphology and angiogenesis of breast cancer in BALB/c mice using trypsin inhibitor from <i>Cucumis melo</i> seeds. <i>In vitro</i> and <i>in vivo</i> study. [PDF]

Contemp Oncol (Pozn)
Rezaei S, Azarpira N, Koohpeyma F, Yousefi R, Doaei S, Heidari M, Gholamalizadeh M, Haghshenas MR, Mazloom Z.   +8 more
europepmc   +1 more source