Results 191 to 200 of about 901,103 (252)

Soybean Trypsin Inhibitor Possesses Potency Against SARS-CoV-2 Infection by Blocking the Host Cell Surface Receptors ACE2, TMPRSS2, and CD147. [PDF]

Int J Mol Sci
Wu WL, Lin JG, Jiang WP, Hung HP, Inose A, Huang GJ.   +5 more
europepmc   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Amylase/trypsin-inhibitor content and inhibitory activity of German common wheat landraces and modern varieties do not differ. [PDF]

NPJ Sci Food
Jahn N, Geisslitz S, Konradl U, Fleissner K, Scherf KA.   +4 more
europepmc   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) in saliva of pigs: evaluation of two commercially available ELISA kits for its measurement and distribution of its main components. [PDF]

PLoS One
Ortín-Bustillo A, Martínez-Subiela S, Cerón JJ, González-Bulnes A, Tvarijonaviciute A, Muñoz-Prieto A.   +5 more
europepmc   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Interaction of Human Sperm Acrosomal Proteinase with Human seminal Plasma Proteinase Inhibitors [PDF]

, 1973
Zaneveld, L. J. D., Schumacher, D. F. B., Jaumann, Eugen, Fritz, Hans, Fink, Edwin   +4 more
core   +1 more source

Acute toxicity of trypsin inhibitor from tamarind seeds in embryo and adult zebrafish (Danio rerio). [PDF]

Toxicol Rep
Dos Santos Melo YL, Luchiari AC, Lopes BS, Ferreira Rocha Silva MG, Dos Santos Pais T, Procópio Gama Cortez JE, da Silva Camillo C, Bezerra de Moura SA, da Silva-Maia JK, de Araújo Morais AH.   +9 more
europepmc   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Increasing dietary soybean-derived trypsin inhibitor protein compromises nursery pig performance, nitrogen digestibility, and retention. [PDF]

J Anim Sci
Nisley MJ, Miller KA, Spencer JD, Mendoza OF, Krishnan HB, Gabler NK.   +5 more
europepmc   +1 more source