Results 91 to 100 of about 150,807 (262)

Crystal structure of Kunitz-type trypsin inhibitor: Entomotoxic effect of native and encapsulated protein targeting gut trypsin of Tribolium castaneum Herbst

Computational and Structural Biotechnology Journal
Trypsin inhibitors are known to act against insect pests by inhibiting proteases of the digestive tract. In this study, we report structural and functional characterization of ∼ 19 kDa Albizia procera Kunitz-type trypsin inhibitor (ApKTI) protein with ...
Sohaib Mehmood, Soren Skou Thirup, Sarah Ahmed, Nabila Bashir, Ahsan Saeed, Maria Rafiq, Qamar Saeed, Muhammad Najam-ul-Haq, Binish Khaliq, Muhammad Ibrahim, Wadi Brak Alonazi, Ahmed Akrem   +11 more
doaj   +1 more source

Improving the understanding of plasma kallikrein contribution to arterial thrombus formation using two plant protease inhibitors

Platelets, 2019
The purpose of antithrombotic therapy is the prevention of thrombus formation and/or its extension with a minimum risk of bleeding. The inhibition of a variety of proteolytic processes, particularly those of the coagulation cascade, has been reported as ...
Bruno R Salu, Silvana Cristina Pando, Marlon V De Brito, André Fernando Medina, Frank Odei-Addo, Carminita Frost, Ryno Naude, Misako U Sampaio, Jonas Emsley, Francisco Humberto A. Maffei, Maria Luiza V Oliva   +10 more
doaj   +1 more source

Protease Inhibitors from Marine Venomous Animals and Their Counterparts in Terrestrial Venomous Animals

Marine Drugs, 2013
The Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms.
Caroline B. F. Mourão, Elisabeth F. Schwartz   +1 more
doaj   +1 more source

Breeding from 1891 to 2010 did not increase the content of amylase/trypsin-inhibitors in wheat (Triticum aestivum). [PDF]

NPJ Sci Food, 2023
Geisslitz S, Pronin D, Neerukonda M, Curella V, Neufang S, Koch S, Weichert H, Weber H, Börner A, Schuppan D, Scherf KA.   +10 more
europepmc   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Free-Energy Landscape and Rate Estimation of the Aromatic Ring Flips in Basic Pancreatic Trypsin Inhibitors Using Metadynamics. [PDF]

J Chem Theory Comput, 2023
Kulkarni M, Söderhjelm P.
europepmc   +1 more source

Engineering a Sonotherapeutic RBC Membrane‐Derived Nanoparticle Platform for the Treatment of Liver Cancer

Advanced Functional Materials, EarlyView.
Herein, an RBC membrane‐derived nanoparticle (CMN‐ICG) is engineered to efficiently deliver a sonosensitizing agent, indocyanine green (ICG), for sonotherapy of hepatocellular carcinoma (HCC). CMN‐ICG exhibits excellent cytocompatibility, significantly enhances hepatocyte uptake, and produces excessive reactive oxygen species (ROS) upon ultrasound ...
Alap Ali Zahid, Aishik Chakraborty, Wei Luo, Juhi Bora, John Joseph Kelly, John Andrew Ronald, Arghya Paul   +6 more
wiley   +1 more source

Small molecule peptidomimetic trypsin inhibitors: validation of an EKO binding mode, but with a twist. [PDF]

Org Biomol Chem, 2022
Lyu RL, Joy S, Packianathan C, Laganowsky A, Burgess K.   +4 more
europepmc   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source

Trypsin inhibitors in seeds and pods of Phaseolus vulgaris/coccineus: A comparative study of shaking and ultrasonic extraction methods

Electronic Journal of Biotechnology
Background: Different methods for the extraction of trypsin inhibitors in beans (Phaseolus spp.) were investigated. Two randomised complete laboratory experiments were performed, one on the seeds and one on the pods.
Hourieh Tavakoli Hasanaklou, Barbara Pipan, Vladimir Meglič, Nevena Nagl, Lovro Sinkovič   +4 more
doaj   +1 more source