Results 71 to 80 of about 259,629 (307)
Novel Inhibitors and Activity-Based Probes Targeting Trypsin-Like Serine Proteases
Frontiers in Chemistry, 2022 The trypsin-like proteases (TLPs) play widespread and diverse roles, in a host of physiological and pathological processes including clot dissolution, extracellular matrix remodelling, infection, angiogenesis, wound healing and tumour invasion/metastasis.
Timothy E. G. Ferguson +3 more
doaj +1 more source
NMR solution structure of a chymotrypsin inhibitor from the Taiwan cobra Naja naja atra [PDF]
, 2013 The Taiwan cobra (Naja naja atra) chymotrypsin inhibitor (NACI) consists of 57 amino acids and is related to other Kunitz-type inhibitors such as bovine pancreatic trypsin inhibitor (BPTI) and Bungarus fasciatus fraction IX (BF9), another chymotrypsin ...
Chang, Long-Sen +3 more
core +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
BIOLOGICAL VALUE OF TOMATO PROCESSING BY-PRODUCTS
Harčova Nauka ì Tehnologìâ, 2021 The article analyzes the biological value of secondary products of tomato processing, namely tomato seeds, which, for the most part, is not considered as an object of processing.
O. Benderska +4 more
doaj +1 more source
Fluorescence-based proteasome activity profiling [PDF]
, 2012 With the proteasome emerging as a therapeutic target for cancer treatment, accurate tools for monitoring proteasome (inhibitor) activity are in demand.
Berkers, C.R. +4 more
core +1 more source
Trypsin Inhibitor in Guar Meal
Experimental Biology and Medicine, 1966 SummaryThe presence of trypsin inhibitor in Guar meal has been demonstrated by the trypsin-hemoglobin digestion procedure. The level of inhibition is concentration dependent. The inhibitor is destroyed by heating and is apparently not dialyzable, which may be indicative of a macromolecular nature.
J R, Couch, C R, Creger, Y K, Bakshi
openaire +2 more sources
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury. [PDF]
, 2013 The small intestine plays a key role in the pathogenesis of multiple organ failure following circulatory shock. Current results show that reduced perfusion of the small intestine compromises the mucosal epithelial barrier, and the intestinal contents ...
Altshuler, Angelina E +5 more
core +2 more sources
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Not more than three tissue kallikreins identified from organs of the guinea pig [PDF]
, 1999 The large and varied multigene families of tissue kallikreins of rat and mouse are considered to selectively release as many bioactive peptides. In order to determine whether a similar family of enzymes is expressed in the organs of the guinea pig ...
Geiger +6 more
core +1 more source