Results 101 to 110 of about 267,223 (312)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Ultrasound-enhanced interfacial adsorption and inactivation of soy trypsin inhibitors. [PDF]

Ultrason Sonochem, 2023
Wu Y, Li W, Zhu H, Martin GJO, Ashokkumar M.   +4 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review. [PDF]

J Enzyme Inhib Med Chem, 2022
de Souza Nascimento AM, de Oliveira Segundo VH, Felipe Camelo Aguiar AJ, Piuvezam G, Souza Passos T, Florentino da Silva Chaves Damasceno KSFDS, de Araújo Morais AH.   +6 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Avaliação biológica de soja com baixas atividades de inibidores de tripsina e ausência do inibidor Kunitz

Archivos Latinoamericanos de Nutrición, 2001
Cultivar de soja BR 36 com atividades de inibidores de tripsina convencional e linhagem BRM 95-5262, geneticamente modificadas para conter baixas atividades de inibidores de tripsina, contendo 40 e 20 e 30 e 20% de atividades residuais relativa de ...
Edna Mayumi Yuahasi Miura, Marco Aurélio R. Binotti, Daliane Souza de Camargo, Ivone Yurika Mizubuti, Elza Iouko Ida   +4 more
doaj  

Spiders' digestive system as a source of trypsin inhibitors: functional activity of a member of atracotoxin structural family. [PDF]

Sci Rep, 2023
Neto OBS, Valladão R, Coelho GR, Dias R, Pimenta DC, Lopes AR.   +5 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Crystal structure of Kunitz-type trypsin inhibitor: Entomotoxic effect of native and encapsulated protein targeting gut trypsin of Tribolium castaneum Herbst

Computational and Structural Biotechnology Journal
Trypsin inhibitors are known to act against insect pests by inhibiting proteases of the digestive tract. In this study, we report structural and functional characterization of ∼ 19 kDa Albizia procera Kunitz-type trypsin inhibitor (ApKTI) protein with ...
Sohaib Mehmood, Soren Skou Thirup, Sarah Ahmed, Nabila Bashir, Ahsan Saeed, Maria Rafiq, Qamar Saeed, Muhammad Najam-ul-Haq, Binish Khaliq, Muhammad Ibrahim, Wadi Brak Alonazi, Ahmed Akrem   +11 more
doaj   +1 more source

Improving the understanding of plasma kallikrein contribution to arterial thrombus formation using two plant protease inhibitors

Platelets, 2019
The purpose of antithrombotic therapy is the prevention of thrombus formation and/or its extension with a minimum risk of bleeding. The inhibition of a variety of proteolytic processes, particularly those of the coagulation cascade, has been reported as ...
Bruno R Salu, Silvana Cristina Pando, Marlon V De Brito, André Fernando Medina, Frank Odei-Addo, Carminita Frost, Ryno Naude, Misako U Sampaio, Jonas Emsley, Francisco Humberto A. Maffei, Maria Luiza V Oliva   +10 more
doaj   +1 more source