Free-Energy Landscape and Rate Estimation of the Aromatic Ring Flips in Basic Pancreatic Trypsin Inhibitors Using Metadynamics. [PDF]
Kulkarni M, Söderhjelm P.
europepmc +1 more source
Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou+2 more
wiley +1 more source
Small molecule peptidomimetic trypsin inhibitors: validation of an EKO binding mode, but with a twist. [PDF]
Lyu RL+4 more
europepmc +1 more source
The MPTT‐nanozyme‐hydrogel system (Mn3O4@ChS‐HA) provides a multifunctional therapeutic strategy for intervertebral disc degeneration (IVDD), effectively targeting oxidative stress and enhancing AF repair by restoring extracellular matrix (ECM) and redox homeostasis.
Yangyang Chen+13 more
wiley +1 more source
Digestibility of wheat alpha-amylase/trypsin inhibitors using a caricain digestive supplement. [PDF]
Juhász A+3 more
europepmc +1 more source
Fehérje-kölcsönhatások szerkezeti alapjainak feltárása és a kölcsönhatás szelektív gátlása irányított evolúciós eljárásokkal = Deciphering the structural basis of protein-protein interactions and their selective inhibition via directed evolutionary methods [PDF]
Fő célom az volt, hogy meghonosítsam az irányított fehérjeevolúció szemléletét, és legsikeresebb technológiáját, a fágbemutatást. Egyrészt azt kutattuk, mi szabja meg a proteáz inhibitorok affinitását és specifitását.
Gráf, László+2 more
core
A multifunctional hydroxyapatite (HAp) coating integrated with silver‐gallium liquid metal nanoparticles (HAp‐Ag‐GaNPs) exhibits dual antibacterial and osteogenic properties. It effectively inhibits Gram‐positive and Gram‐negative bacteria, including resistant strains, while enhancing bone regeneration.
Ngoc Huu Nguyen+17 more
wiley +1 more source
Amylase Trypsin Inhibitors (ATIs) in a Selection of Ancient and Modern Wheat: Effect of Genotype and Growing Environment on Inhibitory Activities. [PDF]
Simonetti E, Bosi S, Negri L, Dinelli G.
europepmc +1 more source
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang+9 more
wiley +1 more source