Results 171 to 180 of about 267,223 (312)

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

A Heparin‐Functionalized Scaffold with HB‐EGF Immobilization for Tissue Engineering

Advanced Healthcare Materials, EarlyView.
In this study, a heparin‐functionalized scaffold is designed for bio‐mimicking growth factors reservoir function of extracellular matrix. Due to the presence of heparin‐binding domain, heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is effectively and spatially captured by heparin‐functionalized scaffold.
Bowu Peng, Huajian Chen, Chengyu Lu, Tianjiao Zeng, Man Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen   +8 more
wiley   +1 more source

Comparative quantitative LC-MS/MS analysis of 13 amylase/trypsin inhibitors in ancient and modern Triticum species. [PDF]

Sci Rep, 2020
Geisslitz S, Longin CFH, Koehler P, Scherf KA.   +3 more
europepmc   +1 more source

The Role of Proaccelerin in Human Blood Coagulation. Evidence that Proaccelerin Is Converted to a Prothrombin-converting Principle by Activated Stuart Factor: With Notes on the Anticoagulant Action of Soybean Trypsin Inhibitor, Protamine Sulfate, and Hexadimethrine Bromide* [PDF]

, 1965
Robert T. Breckenridge, Oscar D. Ratnoff
openalex   +1 more source

Injectable Dual‐Crosslinked Poly(oligo(Ethylene Glycol) Methacrylate) Hydrogels Inspired by Mussel Adhesion for Cutaneous Wound Healing and Functional Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Injectable POEGMA‐DA hydrogels, dual‐crosslinked via dopamine self‐polymerization and dynamic hydrazone bonds, provide a safer alternative to invasive wound closure methods and toxic bioadhesives. Mimicking skin‐like mechanics, they achieve effective tissue adhesion for acute dermal wounds, supporting improved healing outcomes, including reducing ...
Gurpreet Kaur Randhawa, Meghan Kostashuk, Zhicheng Pan, Nils Nordstrom, Thomas Kalab, Erica Winterhelt, Todd Hoare   +6 more
wiley   +1 more source

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

The Genetic Factors Controlling the Accumulation of Amylase/Trypsin Inhibitors (ATIs) in Barley for Enhancing Human Nutrition and Health. [PDF]

Food Sci Nutr
Alomari DZ, Thabet SG, Alqahtani MD, Schierenbeck M, Joestl S, Geisslitz S, Scherf KA, Börner A, Alqudah AM.   +8 more
europepmc   +1 more source

Use of microwaves to improve nutritional value of soybeans for future space inhabitants [PDF]

Whole soybeans from four different varieties at different moisture contents were microwaved for varying times to determine the conditions for maximum destruction of trypsin inhibitor and lipoxygenase activities, and optimal growth of chicks.
Singh, G.
core   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Comprehensive Characterization and Relative Quantification of α-Amylase/Trypsin Inhibitors from Wheat Cultivars by Targeted HPLC-MS/MS. [PDF]

Foods, 2020
Sagu ST, Zimmermann L, Landgräber E, Homann T, Huschek G, Özpinar H, Schweigert FJ, Rawel HM.   +7 more
europepmc   +1 more source