Results 261 to 270 of about 256,479 (340)
Advanced Science, EarlyView.LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li +8 more
wiley +1 more source
Occurrence of a trypsin inhibitor in eggplant exocarps.
, 1975 Masao Kanamori +4 more
openalex +2 more sources
Advanced Science, EarlyView.This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang +13 more
wiley +1 more source
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, EarlyView.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA
Advanced Science, EarlyView.Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin +9 more
wiley +1 more source
Advanced Science, EarlyView.The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang +11 more
wiley +1 more source
Origins of Circular Dichroism bands in Bowman--Birk soybean trypsin inhibitor
, 1975 Ernest Kay
openalex +2 more sources
Advanced Science, EarlyView.FfRlpA2, a conserved Fusarium effector, functions as a protease inhibitor by hijacking the E3 ubiquitin ligase IbCHYR1 to degrade the resistance factor IbZnFR, thereby promoting Fusarium pathogenicity. Conversely, the high dosage Pro::IbZnFRHap2 allele was associated with resistance to root rot disease.
Huan Zhang +14 more
wiley +1 more source
Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase
Advanced Science, EarlyView.Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo +17 more
wiley +1 more source