Results 31 to 40 of about 259,629 (307)

Development of a novel, high-affinity ssDNA trypsin inhibitor

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Inhibitors of serine proteases are not only extremely useful in the basic research but are also applied extensively in clinical settings. Using Systematic Evolution of Ligands by Exponential Enrichment (SELEX) approach we developed a family of novel ...
Stanislaw Malicki, Miroslaw Ksiazek, Pawel Majewski, Aleksandra Pecak, Piotr Mydel, Przemyslaw Grudnik, Grzegorz Dubin   +6 more
doaj   +1 more source

Determinação da atividade antitríptica em proteínas de produtos do amendoim isoladas por cromatografia de afinidade

Química Nova, 2014
The peanut is an oleaginous plant of high nutritional value, a source of protein and a trypsin inhibitor. Trypsin inhibitors are proteins present in the vegetable kingdom, considered anti-nutritional factors for animals.
Jéssica Morais de Araújo, Jussara Cristina Alves, Thayane Kerbele Oliveira das Neves Peixoto, Amanda Fernandes de Medeiros, Richele Janaína de Araújo Machado, Alexandre Coelho Serquiz, Renata Alexandra Moreira das Neves, Elizeu Antunes dos Santos, Adriana Ferreira Uchôa, Ana Heloneida de Araújo Morais   +9 more
doaj   +1 more source

Crystal structures of a plant trypsin inhibitor from Enterolobium contortisiliquum (EcTI) and of its complex with bovine trypsin. [PDF]

PLoS ONE, 2013
A serine protease inhibitor from Enterolobium contortisiliquum (EcTI) belongs to the Kunitz family of plant inhibitors, common in plant seeds. It was shown that EcTI inhibits the invasion of gastric cancer cells through alterations in integrin-dependent ...
Dongwen Zhou, Yara A Lobo, Isabel F C Batista, Rafael Marques-Porto, Alla Gustchina, Maria L V Oliva, Alexander Wlodawer   +6 more
doaj   +1 more source

Calorimetry of Some Trypsin-Trypsin Inhibitor Reactions

Journal of Biological Chemistry, 1972
The heats of reaction of trypsin with soybean (Kunitz), ovomucoid, and lima bean inhibitors have been measured at pH 5.0 and 10° and 25°. All the reactions were endothermic, with ΔH ranging from 8.6 Cal per mole for the lima bean inhibitor to 15.3 Cal per mole for the soybean inhibitor. Equilibrium constants for the association were calculated from the
R J, Baugh, C G, Trowbridge
openaire   +2 more sources

Effect of thermally untreated soybean with low levels of Kunitz trypsin inhibitors in the diet of broilers [PDF]

Agroznanje, 2011
This paper researched the effect of raw Kunitz free trypsin inhibitor soybean sort "Lana" to the production characteristics of broilers (Ross 308), compared to raw soybeans with a standard level of trypsin inhibitors. The production results indicate that
Beuković Dejan, Ljubojević D., Beuković Miloš, Đorđević Nenad, Milošević Niko, Stanaćev Vidica   +5 more
doaj  

Overexpression of soybean trypsin inhibitor genes decreases defoliation by corn earworm (Helicoverpa zea) in soybean (Glycine max) and Arabidopsis thaliana

Frontiers in Plant Science, 2023
Trypsin inhibitors (TIs) are widely distributed in plants and are known to play a protective role against herbivores. TIs reduce the biological activity of trypsin, an enzyme involved in the breakdown of many different proteins, by inhibiting the ...
Mst Shamira Sultana, Mst Shamira Sultana, Mitra Mazarei, Mitra Mazarei, Juan Luis Jurat-Fuentes, Tarek Hewezi, Reginald J. Millwood, C. Neal Stewart, C. Neal Stewart   +8 more
doaj   +1 more source

Organization and sequence of the gene encoding the human acrosin-trypsin inhibitor (HUSI-II) [PDF]

, 1993
A complete cDNA encoding the acrosin-trypsin inhibitor, HUSI-II, was used as a probe to isolate genomic clones from a human placenta library. Three clones which cover the entire HUSI-II gene were isolated and characterized.
Abelson, Baumann, Beato, Bird, Dynan, Fink, Fink, Greene, Greene, Haendle, Hehlein-Fink, Horii, Kazal, Laskowski, Laskowski, LaThangue, Luerssen, Mead, Moritz, Policastro, Reynolds, Sambrook, Scott, Stein, Strähle, Stühmer, Tan, Tora, Weih   +28 more
core   +1 more source

Variability of antinutritive compounds in flaxseed flours

International Journal of Plant Biology, 2013
The use of flaxseed flours in the diets of poultry and broilers may be limited by the presence of antinutritive compounds. The content of cyanogenic glycosides, phytic acid, condensed tannins and trypsin inhibitors was evaluated in seven varieties of ...
Roberto Russo, Remo Reggiani
doaj   +1 more source

Engineering trypsin for inhibitor resistance [PDF]

Protein Science, 2015
AbstractThe development of effective protease therapeutics requires that the proteases be more resistant to naturally occurring inhibitors while maintaining catalytic activity. A key step in developing inhibitor resistance is the identification of key residues in protease‐inhibitor interaction. Given that majority of the protease therapeutics currently
Anna R, Batt, Commodore P, St Germain, Trevor, Gokey, Anton B, Guliaev, Teaster, Baird   +4 more
openaire   +2 more sources

Effects of specific inhibitors on the gene expression of a digestive trypsin in Pieris brassicae L. (Lepidoptera: Pieridae)

Journal of Plant Protection Research, 2018
Protein digestion in insects relies on several groups of proteases, among which trypsin plays a prominent role. In the current study, larvae of Pieris brassicae L.
Ali Sharifloo, Arash Zibaee, Jalal Jalali Sendi, Khalil Talebi Jahromi   +3 more
doaj   +1 more source