Results 41 to 50 of about 155,237 (261)

Cinética de inativação de inibidores de tripsina e de insolubilização de proteínas de diferentes cultivares de soja Inactivation kinetics of low activity trypsin inhibitors and protein insolubilization of different soybean cultivars

Revista Brasileira de Zootecnia, 2005
A soja (Glycine max (L.) Merrill) é uma das leguminosas mais estudadas, em virtude de sua intensa utilização como fonte de óleo comestível e proteína para alimentação humana e animal.
Edna Mayumi Yuahasi Miura, Rui Sérgio dos Santos Ferreira da Silva, Ivone Yurika Mizubuti, Elza Iouko Ida   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

In-vitro effects of biochemical factors on trypsin activity from intestine and pyloric caeca of common kilka (Clupeonella cultriventris caspia) for inhibition of belly bursting

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2011
The in-vitro effects of biochemical factors on trypsin activity from intestine and pyloric caeca of common kilka (Clupeonella cultriventris caspia) was evaluated. Trypsin is known to cause belly bursting in common kilka.
A. Zamani; M. Rezaei email ; R. Madani
doaj  

Assessment and partial purification of serine protease inhibitors from Rhipicephalus (Boophilus) annulatuslarvae

Revista Brasileira de Parasitologia Veterinária
Ticks are rich sources of serine protease inhibitors, particularly those that prevent blood clotting and inflammatory responses during blood feeding. The tick Rhipicephalus (Boophlus) annulatusis an important ectoparasite of cattle.
Sedigheh Nabian, Mohammad Taheri, Mohammad Mehdi Ranjbar, Alireza Sazmand, Parastou Youssefy, Gholam Reza Nazaralipour   +5 more
doaj   +1 more source

Fusion assays for screening of fusion inhibitors targeting SARS-CoV-2 entry and syncytia formation

Frontiers in Pharmacology, 2022
Virus fusion process is evolutionarily conserved and provides a promising pan-viral target. Cell-cell fusion leads to syncytial formation and has implications in pathogenesis, virus spread and immune evasion.
Shiu-Wan Chan
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Characterization and pharmacological properties of a novel multifunctional Kunitz inhibitor from Erythrina velutina seeds.

PLoS ONE, 2013
Inhibitors of peptidases isolated from leguminous seeds have been studied for their pharmacological properties. The present study focused on purification, biochemical characterization and anti-inflammatory and anticoagulant evaluation of a novel Kunitz ...
Richele J A Machado, Norberto K V Monteiro, Ludovico Migliolo, Osmar N Silva, Michele F S Pinto, Adeliana S Oliveira, Octávio L Franco, Sumika Kiyota, Marcelo P Bemquerer, Adriana F Uchoa, Ana H A Morais, Elizeu A Santos   +11 more
doaj   +1 more source

BIOLOGICAL VALUE OF TOMATO PROCESSING BY-PRODUCTS

Harčova Nauka ì Tehnologìâ, 2021
The article analyzes the biological value of secondary products of tomato processing, namely tomato seeds, which, for the most part, is not considered as an object of processing.
O. Benderska, A. Bessarab, B. Iegorov, M. Kashkano, V. Shutyuk   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Novel Inhibitors and Activity-Based Probes Targeting Trypsin-Like Serine Proteases

Frontiers in Chemistry, 2022
The trypsin-like proteases (TLPs) play widespread and diverse roles, in a host of physiological and pathological processes including clot dissolution, extracellular matrix remodelling, infection, angiogenesis, wound healing and tumour invasion/metastasis.
Timothy E. G. Ferguson, James A. Reihill, S. Lorraine Martin, Brian Walker   +3 more
doaj   +1 more source