Results 261 to 270 of about 33,741 (291)

Molecular and Functional Assessment of TSC1 and TSC2 in Individuals with Tuberous Sclerosis Complex. [PDF]

Genes (Basel)
Dufner-Almeida LG, Cardozo LFM, Schwind MR, Carvalho D, Almeida JPG, Cappellano AM, Alegria TGP, Nanhoe S, Nellist M, Passos-Bueno MR, Chiavegatto S, Silva NS, Rosemberg S, Pereira APA, Antoniuk SA, Haddad LA.   +15 more
europepmc   +1 more source

mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteins. [PDF]

EMBO Rep
Bankolé A, Srivastava A, Shihavuddin A, Tighanimine K, Faucourt M, Koka V, Weill S, Nemazanyy I, Nelson AJ, Stokes MP, Delgehyr N, Genovesio A, Meunier A, Fumagalli S, Pende M, Spassky N.   +15 more
europepmc   +1 more source

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Role of TSC1 in physiology and diseases

Molecular and Cellular Biochemistry, 2021
Since its initial discovery as the gene altered in Tuberous Sclerosis Complex (TSC), an autosomal dominant disorder, the interest in TSC1 (Tuberous Sclerosis Complex 1) has steadily risen. TSC1, an essential component of the pro-survival PI3K/AKT/MTOR signaling pathway, plays an important role in processes like development, cell growth and ...
K. Mallela, Arun Kumar
semanticscholar   +4 more sources

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.

Science, 1997
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the widespread development of distinctive tumors termed hamartomas. TSC-determining loci have been mapped to chromosomes 9q34 (TSC1) and 16p13 (TSC2).
S. Uyeda, J. Sclater, M. V. Slegtenhorst, R. D. Hoogt, C. Hermans, M. Nellist, B. Janssen, S. Verhoef, D. Lindhout, A. V. D. Ouweland, D. Halley, Janet M. Young, Mariwyn Burley, Steve Jeremiah, K. Woodward, J. Nahmias, M. Fox, R. Ekong, J. Osborne, J. Wolfe, S. Povey, R. Snell, J. Cheadle, A. Jones, Maria Tachataki, D. Ravine, J. Sampson, M. Reeve, Paul Richardson, Friederike Wilmer, Cheryl Munro, T. Hawkins, T. Sepp, S. Ward, A. J. Green, J. Yates, J. Kwiatkowska, E. Henske, M. Short, J. Haines, S. Jóźwiak, D. Kwiatkowski   +41 more
semanticscholar   +5 more sources

Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others

American Journal of Surgical Pathology, 2023
Renal cell carcinoma with fibromyomatous stroma (RCCFMS) include ELOC/TCEB1-mutated renal cell carcinoma (RCC) and those with TSC1/2/MTOR alterations.
Huili Li, P. Argani, Eitan Halper-Stromberg, Tamara L. Lotan, Maria J. Merino, V. Reuter, A. Matoso   +6 more
semanticscholar   +1 more source

Low‐grade oncocytic tumour of the kidney is characterised by genetic alterations of TSC1, TSC2, MTOR or PIK3CA and consistent GATA3 positivity

Histopathology, 2022
Low‐grade oncocytic tumour (LOT) of the kidney has recently emerged as a potential novel tumour type. Despite similarity to oncocytoma or eosinophilic chromophobe renal cell carcinoma, it shows diffuse keratin 7 immunohistochemistry (IHC) and negative ...
S. Williamson, O. Hes, K. Trpkov, A. Aggarwal, Abhishek Satapathy, Sourav K. Mishra, Shivani Sharma, Ankur R. Sangoi, L. Cheng, Mahmut Akgul, Muhammad T. Idrees, A. Levin, Sudha M. Sadasivan, P. San Miguel Fraile, J. Rogala, E. Compérat, D. Berney, S. Bulimbasic, J. McKenney, Shilpy Jha, Nakul Y Sampat, S. Mohanty   +21 more
semanticscholar   +1 more source

Evolution of the TSC1/TSC2-TOR Signaling Pathway

Science Signaling, 2010
The TSC1/TSC2-TOR signaling pathway evolved from a primitive signaling pathway linking adenosine monophosphate abundance to cell growth.
Jaco Serfontein, R. Ellen R. Nisbet, Christopher J. Howe, Petrus J. de Vries   +3 more
openaire   +4 more sources

Molecular analysis of the TSC1 gene in adenocarcinoma of the lung

Lung Cancer, 2004
We previously reported that loss of heterozygosity (LOH) in tuberous sclerosis 1 (TSC1)-gene-associated region on chromosome 9q34, was frequently observed in adenocarcinoma (AC) of the lung and its putative precursor lesion, atypical adenomatous hyperplasia (AAH).
Kazuya Suzuki, Kazuya Takamochi, Atsushi Ochiai, Hiroyasu Esumi, Tsutomu Ogura, Yutaka Nishiwaki, Tomoyuki Yokose, Kanji Nagai   +7 more
openaire   +2 more sources