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Prognostic implication of TSC1 and mTOR expression in gastric carcinoma
Journal of Surgical Oncology, 2014BackgroundGastric adenocarcinoma is the sixth most common and third most lethal cancer in the world. Except for HER2‐targeted therapy, targeted agents against specific molecules participating in gastric carcinogenesis, including those in the mechanistic target of rapamycin (serine/threonine kinase) (mTOR) pathway have not been proved to be effective ...
Sun-Ju Byeon +4 more
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Science Signaling, 2015
TSC1 functions independently of TSC2 and mTORC1 to promote TGF-β signaling.
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TSC1 functions independently of TSC2 and mTORC1 to promote TGF-β signaling.
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The role of TSC1 and TSC2 proteins in neuronal axons
Molecular PsychiatryTuberous Sclerosis Complex 1 and 2 proteins, TSC1 and TSC2 respectively, participate in a multiprotein complex with a crucial role for the proper development and function of the nervous system. This complex primarily acts as an inhibitor of the mechanistic target of rapamycin (mTOR) kinase, and mutations in either TSC1 or TSC2 cause a ...
Vasiliki Karalis +3 more
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Acquired Cardiomyopathy Caused by Cardiac Tsc1 Deficiency
Journal of Genetics and Genomics, 2014Hongbing Zhang +5 more
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Mutation landscape of TSC1/TSC2 in Chinese patients with tuberous sclerosis complex
Journal of Human Genetics, 2020Yuhuan Meng +7 more
semanticscholar +1 more source
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling.
Biochemical and Biophysical Research Communications - BBRC, 2018Huajie Li +8 more
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