Results 201 to 210 of about 16,704 (236)

Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes

Journal of Dermatological Science, 2012
Background: Thymic stromal lymphopoietin (TSLP), highly expressed in keratinocytes in atopic dermatitis patients and bronchial epithelial cells in asthma patients, plays a key role in allergic diseases.
Toshiro Takai, Hideoki Ogawa
exaly   +2 more sources

Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases [PDF]

EMBO Molecular Medicine
Thymic stromal lymphopoietin (TSLP) is a key player in atopic diseases, which has sparked great interest in therapeutically targeting TSLP. Yet, no small-molecule TSLP inhibitors exist due to the challenges of disrupting the protein–protein interaction ...
Sarah Hedtrich, Brent D G Page, Awasthi Bp   +2 more
exaly   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk

Journal of Allergy and Clinical Immunology, 2022
Thymic stromal lymphopoietin (TSLP) is an epithelial-derived cytokine important in initiation of allergic inflammation. Single nucleotide polymorphisms (SNPs) in TSLP are associated with asthma, yet studies have shown inconsistent associations between circulating TSLP and asthma.
Matthew Weirauch, Lj Martin, Raphaël Kopan   +2 more
exaly   +3 more sources

The NF‐κB binding site located in the proximal region of the TSLP promoter is critical for TSLP modulation in human intestinal epithelial cells

European Journal of Immunology, 2013
Thymic stromal lymphopoietin (TSLP) is constitutively secreted by intestinal epithelial cells. It regulates gut DCs, therefore, contributing to the maintenance of immune tolerance.
Hervé Blottiere, Nicolas Lapaque, Omar Lakhdari   +2 more
exaly   +2 more sources

TSLP: from allergy to cancer

Nature Immunology, 2019
The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 immune responses has been investigated extensively, recent studies have found an expanding role for TSLP in inflammatory diseases and cancer.
Jonathan Corren, Steven F. Ziegler
openaire   +2 more sources

TSLP: finally in the limelight

Nature Immunology, 2002
TSLP is now revealed to be an important regulator of DC-mediated control of TH2-based human allergic responses, identifying a potentially new species-specific function for this cytokine.
openaire   +1 more source

A possible role for TSLP in inflammatory arthritis

Biochemical and Biophysical Research Communications, 2007
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that triggers dendritic cell-mediated Th2-type inflammatory responses and is considered as a master switch for allergic inflammation. In this study, we found increased levels of TSLP and, also TNF-alpha as previously reported, in synovial fluid specimens derived from patients with rheumatoid ...
Kensuke, Koyama, Tetsuro, Ozawa, Kyosuke, Hatsushika, Takashi, Ando, Shinichi, Takano, Masanori, Wako, Fumiko, Suenaga, Yuko, Ohnuma, Tetsuro, Ohba, Ryohei, Katoh, Hajime, Sugiyama, Yoshiki, Hamada, Hideoki, Ogawa, Ko, Okumura, Atsuhito, Nakao   +14 more
openaire   +2 more sources

Novel Perspectives of TSLP and RXR Signaling in Corticosteroid-Resistant Asthma: Updates on TSLP Blockers

Current Medicinal Chemistry
Previous studies described that asthma patients who received corticosteroid therapy have been constrained by the corticosteroid resistance subsequently fostered to severe refractory asthma. In this review, we discussed the implications of TSLP, RXR, the role of STAT5-activating cytokines, and IL-33/NH-cell signaling pathways, and recent clinical ...
Song, Zhang, Karen, Dsouza, Narasimha Murthy, Beeraka, Junqi, Liu, Oksana, Reshetniak, Hemanth Vikram, Poola Ramachandrappa, Lal Gowri, Priyanka, Greeshma Mandya, Venkata, Shalini Hassan, Doreswamy, Pradeep Kumar, Bhupalam, Mahesh Padukudru, Anand, Prasath, Manogaran, Rajashree, Deka, Gurupadayya, Bannimath, Mikhail Yegorovich, Sinelnikov, Vladimir Nikolaevich, Nikolenko, Kirill Vladimirovich, Bulygin, Ruitai, Fan   +17 more
openaire   +2 more sources

TSLP in Asthma — A New Kid on the Block?

New England Journal of Medicine, 2014
Asthma is a complex inflammatory disease in which the airways narrow too easily, too much, and too often. Despite the availability of bronchodilators to widen the constricted airways and inhaled glucocorticoids, many patients with asthma still have uncontrolled airway obstruction.
openaire   +2 more sources

Expression Of TSLP and TSLP-R In Chronic Idiopathic Urticaria

Journal of Allergy and Clinical Immunology, 2014
Patricia M. Sterba, Allen Myers, Sarbjit S. Saini   +2 more
openaire   +1 more source