Results 51 to 60 of about 120,397 (255)

Reported TSS-T regression models.

, 2016
Reported TSS-T regression models.
Wei Zhuang (146641), Hong Yao (348216), Xin Qian (714942), Bisheng Xia (2583211), Yu Qian (153240), Yang Yang (45629)   +5 more
core   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Distribution of functional binding about the TSS.

, 2014
(a) A density plot of the distribution of bound sites within 10 kb of the TSS for both functional and non-functional genes. Inset is a zoom-in of the region +/−1 kb from the TSS (b) Boxplots comparing the distances from the TSS to the binding sites for ...
Jonathan K. Pritchard (113911), Darren A. Cusanovich (531702), Bryan Pavlovic (531703), Yoav Gilad (2481)   +3 more
core   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

FANTOM 5: Discovering TSS-specific transcriptional regulation

, 2013
We use the FANTOM5 data in order to check for the existance of transcirption start site (TSS)-specific regulation. We apply our proven methods to reverse engineering the regulatory network controlling TSS-specific expression.
Mukesh Bansal (494487), Andrea Califano (91999), Yishai Shimoni (413397), Mariano Alvarez (392515), Gonzalo Garcia Lopez (494488), Maria Rodriguez Martinez (494489)   +5 more
core   +1 more source

Distance from intergenic RE to target genes’ TSS.

, 2023
Density plot of distances from intergenic REs to their target genes’ TSS. Negative distance denotes RE being upstream of target TSS. Median absolute distance: 200 Kb. (TIF)
Carrie J. Finno (8501349), Anna R. Dahlgren (9427858), Ted Kalbfleisch (3386948), Sichong Peng (4917220), Callum G. Donnelly (10268873), Rebecca R. Bellone (10268876), Erin N. Hales (9427864), Jessica L. Petersen (10151106)   +7 more
core   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Appendix D. Total suspended sediment (TSS) mass balances from 2004 to 2005, illustrating consistently higher TSS in the fertilized marsh.

, 2016
Total suspended sediment (TSS) mass balances from 2004 to 2005, illustrating consistently higher TSS in the fertilized ...
Linda A. Deegan (2904734), K. Koop-Jakobsen (2917472), Kari A. Galván (2904731), D. C. Drake (2904716), J. Michael Johnson (2904740), Christian Picard (2904752), Bruce J. Peterson (2904746), Lynsey E. Lemay (2917469), Charles Hopkinson (2904770)   +8 more
core   +1 more source