Results 71 to 80 of about 120,397 (255)
Advanced Science, EarlyView.To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai +4 more
wiley +1 more source
Advanced Science, EarlyView.In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang +18 more
wiley +1 more source
Advanced Science, EarlyView.Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo +11 more
wiley +1 more source
Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang +11 more
wiley +1 more source
Mapping and quantifying nascent transcript start sites using TT-TSS-seq.
Transcription initiation is a highly dynamic and tightly regulated process involving the coordinated action of transcription factors, chromatin remodelers, and RNA polymerase, which determine where and when transcription begins.
Richard Mitter (7556573) +4 more
core
H4K16 acetylation status adjacent to transcription start site (TSS).
, 2015 H4K16 acetylation adjacent to the TSS was assessed by calculating the average ChIP/input log ratio at the same distance from the TSS. The numbers in the X axis indicate the distance from TSS. Y axis represents the average ChIP/input log ratio.
Chung-Soo Kim (482388) +7 more
core +1 more source
Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice
Advanced Science, EarlyView.Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang +12 more
wiley +1 more source
Evaluasi Implementasi Traffic Separation Scheme (TSS) Di Selat Sunda
, 2022 Sejak tanggal 1 Juli 2020, Indonesia telah mengimplementasikan bagan pemisahan alur laut atau Traffic Separation Scheme (TSS) di Selat Sunda berdasarkan hasil keputusan sidang plenary International Maritime Organization (IMO).
Wuryaningrum, Nanda Dwi
core
Advanced Science, EarlyView.A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang +12 more
wiley +1 more source
Angewandte Chemie, EarlyView.Metadynamics simulations drive automated reaction exploration of acid‐catalysed drug degradation, generating a network spanning 1720 species and 2471 elementary steps. QM‐based filtering reduces the network to eight candidate pathways for rigorous DFT refinement and microkinetic modelling.
Julius Seumer +5 more
wiley +2 more sources