Results 81 to 90 of about 120,397 (255)
Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang +15 more
wiley +1 more source
Calibration and validation results for TSS.
Calibration and validation results for TSS.
Patricia Smith (5571113) +2 more
core +1 more source
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma +12 more
wiley +1 more source
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Howship Studios
core
Food Hygiene Practices of Vendors and Microbiological Quality of Ready to Eat Foods at Night Markets
This study investigates the relationship between food hygiene practices among night market vendors and the microbiological quality of ready to eat (RTE) foods sold at night markets. ABSTRACT Ready to eat (RTE) foods are popular options in night markets due to their convenience, affordability, and accessibility.
Yu Xin Soon +5 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
The Formal Design Model of a Telephone Switching System (TSS)
A typical real-time system, the Telephone Switching System (TSS), is a highly complicated system in design and implementation. This paper presents the formal design, specification, and modeling of the TSS system using a denotational mathematics known as ...
Yingxu Wang
core +1 more source
Printed Wearable Sweat Rate Sensor for Continuous In Situ Perspiration Measurement
A wireless wearable sweat rate sensor system is presented, featuring digital 3D direct‐write printing on a flexible substrate with microfluidic layers for continuous, real‐time monitoring. Printed encapsulated metal electrodes are used for capacitance measurements, achieving high sensitivity (0.01 μL min−1) while maintaining a compact and lightweight ...
Mohammad Shafiqul Islam +6 more
wiley +1 more source
High‐elevation endemic plants predicted to lose habitat from changing climate in Washington State
Abstract Premise High‐elevation plants face unique challenges from potential climate change impacts that will likely require upslope migration into increasingly smaller suitable habitat. This situation is particularly acute for endemic species that by definition occupy small geographic ranges.
Nicholas L. Gjording +4 more
wiley +1 more source

