Results 51 to 60 of about 146,644 (262)

Experimental Analysis of Oil Cooler Based on Trefoil Screwed Expansion Pipe

Zhileng xuebao, 2015
The traditional oil cooler with smooth tube has low heat transfer coefficient and dead zone in shell side flow, and it easily produces dirt. The trefoil screwed expansion pipe is used to enhance the heat transfer of the traditional oil cooler.
Huang Yuanyuan, Zhou Guoyan, Qian Tailei, An Dongxu, Yang Liu, Zhu Dongsheng   +5 more
doaj  

Metal expansion joints manufacturing by a mechanically assisted laser forming hybrid method – concept

Technical Transactions, 2022
This paper presents the concept of metal expansion joints manufacturing using a mechanically assisted laserforming hybrid method. The metal expansion joints are made of a metal tube of an appropriate diameter and wall thickness with a combined bellow ...
Kurp Piotr, Danielewski Hubert
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Electromagnetic Force Distribution and Deformation Homogeneity of Electromagnetic Tube Expansion With a New Concave Coil Structure

IEEE Access, 2019
In the conventional electromagnetic tube expansion, the end effects generated by the conventional helix coil may lead to inhomogeneous tube deformation in the axial direction.
Li Qiu, Yantao Li, Yijie Yu, A. Abu-Siada, Qi Xiong, Xiaoxiang Li, Liang Li, Pan Su, Quanliang Cao   +8 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Long Bubble Penetration through Viscoelastic Fluids in a Suddenly Contracting and Expanding Tube

Advances in Materials Science and Engineering, 2016
This study investigated the properties of long bubbles penetrating viscoelastic fluids in a suddenly contracting and expanding tube. Injection gas flow is controlled by a mass flow controller (MFC). Some of dimensionless parameters, such as the capillary
Ching-Chuan Chang, Huang-Chih Lin, Ming-Yuan Lin, Te-Hui Tsai   +3 more
doaj   +1 more source

Simulation studies on Tube End Expansion of AA2014 Alloy Tubes

IOP Conference Series: Materials Science and Engineering, 2018
End forming is defined as forming the end of tubular forms either by inverting the tube or by expanding it. It finds application in many fields such as in automotive and aerospace sectors as power transmission elements, fuel lines, exhaust pipes etc. The main aim of the present work is to expand the AA2014 alloy tubes with different die sets without ...
L Venugopal, N E C Prasad, P Geeta Krishna, L Praveen   +3 more
openaire   +1 more source