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Tuber and Tuberous Root Development [PDF]

open access: yesAnnual Review of Plant Biology, 2021
Root and tuber crops have been an important part of human nutrition since the early days of humanity, providing us with essential carbohydrates, proteins, and vitamins. Today, they are especially important in tropical and subtropical regions of the world, where they help to feed an ever-growing population.
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Tuberous Sclerosis

Developmental Medicine & Child Neurology, 1966
SUMMARYThirty‐four cases of tuberous sclerosis are discussed and the pertinent literature is reviewed. As noted in previously reported cases the disease often afflicts the heart, kidneys, retina and bones in addition to the brain.The incidence and pattern of inheritance in tuberous sclerosis has not been completely elucidated.
G W, Paulson, C B, Lyle
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Tuberous Sclerosis

Neurologic Clinics, 1987
Tuberous sclerosis is a multisystem disorder characterized by changes primarily involving the skin, eye, and central nervous system. Although the disease often produces mental retardation and seizures, this is not universal, and some patients with tuberous sclerosis lead a relatively normal life.
R, Hanno, R, Beck
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Tuberous Sclerosis

2018
Tuberous sclerosis is characterized by a classic triad: seizures, mental retardation, and cutaneous angiofibromas; this triad occurs in about 30% of cases.
Stephen H, Tsang, Tarun, Sharma
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Tuberous sclerosis

2013
Tuberous sclerosis complex (TSC) is a genetic multisystem disorder characterized by widespread hamartomas in several organs, including the brain, heart, skin, eyes, kidney, lung, and liver. The affected genes are TSC1 and TSC2, encoding hamartin and tuberin respectively.
P, Curatolo, B L, Maria
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Tuberous Sclerosis: from Tubers to mTOR

Annals of Human Genetics, 2003
SummaryTuberous sclerosis (TSC) is an autosomal dominant hamartoma syndrome whose causative genes (TSC1andTSC2) were identified 5 and 9 years ago respectively. Their encoded proteins are large, and apart from a strong binding interaction with each other, relatively little was known about their biochemical function.
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Tuberous Sclerosis

Dermatologic Clinics, 1995
Tuberous sclerosis complex is a disorder of cellular differentiation and proliferation that is inherited as an autosomal dominant trait with variable penetrance and a high spontaneous mutation rate. Lesions occur in the brain, skin, kidneys, heart, and other organs.
E S, Roach, M R, Delgado
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Physiology of tuberization in plants. (Tubers and tuberous roots.)

1965
The stem and root of certain plant species often become modified into structures whose form and function differ considerably from that of the typical organ. Moreover, though the functions of these two organs, when in their typical form differ considerably among themselves, they assume upon modification a new.
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