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Tuber development.

2014
Abstract During their life cycle, potato plants develop tuberous organs from underground stems called stolons, which allow the rapid development of daughter plants from sprouts at the beginning of the new growing season. The formation and growth of a potato tuber is a complex process that can be divided into separate physiological events.
Kloosterman, B., Bachem, C.
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Tuberous Sclerosis

Developmental Medicine & Child Neurology, 1966
SUMMARYThirty‐four cases of tuberous sclerosis are discussed and the pertinent literature is reviewed. As noted in previously reported cases the disease often afflicts the heart, kidneys, retina and bones in addition to the brain.The incidence and pattern of inheritance in tuberous sclerosis has not been completely elucidated.
G W, Paulson, C B, Lyle
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Tuberous Sclerosis Complex

Seminars in Pediatric Neurology, 2021
Affecting approximately 1 per 6000-10,000 individuals, tuberous sclerosis complex (TSC) is a neurocutaneous disorder that is not only uncommon but at risk to go underrecognized. Similar to other phakomatoses, TSC is a disorder of cellular proliferation and migration producing hamartomas-benign tumors or malignant cancers affecting the skin and brain ...
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Tuberous sclerosis complex

2015
Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome that can affect the brain, skin, eyes, kidneys, heart, and lungs. TSC alters cellular proliferation and differentiation, resulting in hamartomas of various organs, tumor formation, and altered neuronal migration. The phenotype is highly variable.
Monica P, Islam, E Steve, Roach
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Tuberous Sclerosis: from Tubers to mTOR

Annals of Human Genetics, 2003
SummaryTuberous sclerosis (TSC) is an autosomal dominant hamartoma syndrome whose causative genes (TSC1andTSC2) were identified 5 and 9 years ago respectively. Their encoded proteins are large, and apart from a strong binding interaction with each other, relatively little was known about their biochemical function.
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Tuberous Sclerosis Complex

New England Journal of Medicine, 2017
A 71-year-old man presented for the evaluation of chronic kidney disease and was noted to have erythematous papules on his face and lesions over his toenails suggestive of tuberous sclerosis.
Michele, Marchini, Elisabetta, Giglio
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Tuberous sclerosis complex

Nature Reviews Disease Primers, 2016
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple organ systems and is caused by loss-of-function mutations in one of two genes: TSC1 or TSC2. The disorder can affect both adults and children. First described in depth by Bourneville in 1880, it is now estimated that nearly 2 million people are affected by the ...
Elizabeth P, Henske   +4 more
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Physiology of tuberization in plants. (Tubers and tuberous roots.)

1965
The stem and root of certain plant species often become modified into structures whose form and function differ considerably from that of the typical organ. Moreover, though the functions of these two organs, when in their typical form differ considerably among themselves, they assume upon modification a new.
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Male Tuberous Breast

2020
The tuberous male breast is a rare variant of gynecomastia. It does not easily fit into the most popular gynecomastia classification system. It can appear with different clinical forms ranging from a persistent or intermittent intra-areola herniation of parenchyma up to hangs from the thorax with a ptotic, constricted, and very mobile feminine breast ...
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Tubers of Tuberous Sclerosis

2022
John M. Stern, Noriko Salamon
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