Results 121 to 130 of about 58,147 (226)

The Aetiology of Elevated Total Serum Immunoglobulin E in Children

Acta Paediatrica, Volume 114, Issue 11, Page 2993-2999, November 2025.
ABSTRACT Aim The paucity of real‐world data on the aetiology of elevated total serum immunoglobulin E (TS‐IgE) in children afflicts families and health care systems with diagnostic uncertainty. We explored a cohort of children with TS‐IgE levels over 1000 kU/L, focusing on the prevalence of atopic and non‐atopic conditions, the aetiology of extremely ...
Aliisa Ärölä, Kaarina Kukkonen, Svetlana Vakkilainen   +2 more
wiley   +1 more source

Missing women in colonial India

The Economic History Review, Volume 78, Issue 4, Page 997-1038, November 2025.
Abstract We construct novel data on female population shares by age, district, and religion in South Asia from 1881 to 1931. Sex ratios skew male in Northern India and are more balanced in Southern and Eastern India, including Burma. Male‐biased sex ratios emerge most visibly after age 10, and this is not specific to any one region, religion, or time ...
James Fenske, Bishnupriya Gupta, Cora Neumann   +2 more
wiley   +1 more source

Impact of Concomitant Methotrexate Use and Prior Biologic Disease‐Modifying Antirheumatic Drug Exposure on Tofacitinib Efficacy and Safety in Patients with Polyarticular Course Juvenile Idiopathic Arthritis: Post Hoc Analysis of a Phase 3 Randomized Withdrawal Trial

ACR Open Rheumatology, Volume 7, Issue 10, October 2025.
Objective We evaluate tofacitinib efficacy and safety in patients with juvenile idiopathic arthritis (JIA) stratified by concomitant methotrexate and prior biologic disease‐modifying antirheumatic drug (bDMARD) treatment. Methods In this two part, double‐blind, randomized withdrawal Phase 3 trial (NCT02592434), patients (2–<18 years) with JIA received ...
Nicolino Ruperto, Daniel J. Lovell, Olga Synoverska, Carlos Abud‐Mendoza, Alberto Spindler, Yulia Vyzhga, Iris Reyhan, Lyudmila Grebenkina, Irit Tirosh, Lisa Imundo, Peter Chiraseveenuprapund, Daniel J Kingsbury, Betul Sozeri, Sheetal S. Vora, Sampath Prahalad, Elena Zholobova, Kevin D. Roberts, Gosford Sawyerr, Andreas Blum, Andrea Shapiro, Annette Diehl, Abbas Ebrahim, Pascal Klaus, Alberto Martini, Hermine I. Brunner, for the Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)   +25 more
wiley   +1 more source

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds

Advanced Science, Volume 12, Issue 37, October 6, 2025.
ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy
Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao   +27 more
wiley   +1 more source

Body Size and Risk of Death During the 1918 Influenza Pandemic in Alaska

American Journal of Human Biology, Volume 37, Issue 10, October 2025.
ABSTRACT In the aftermath of the 2009 H1N1 influenza A pandemic, research revealed the relationship between body size and the severity of influenza outcomes. However, there is little data available on body size in historical populations; therefore, the relationship between body size and 1918 influenza pandemic outcomes is virtually unknown.
Taylor P. van Doren, Lauren E. Steele, Emma Tinker‐Fortel, Lisa Sattenspiel   +3 more
wiley   +1 more source

Post-tuberculosis morbidities and their associated mortality: moving from challenges to solutions. [PDF]

Eur Respir Rev
Wang J, Yuan B, Fang Y, Zhao C, Liu J, Xiong K.   +5 more
europepmc   +1 more source

Pan-Immune-Inflammatory value and risk of latent tuberculosis infection. [PDF]

Sci Rep
Ye X, Kang X, Zhang H, Wang W.
europepmc   +1 more source

Effect of Long‐Term Voclosporin Treatment on Renal Histology in Patients With Active Lupus Nephritis With Repeat Renal Biopsies

Arthritis &Rheumatology, Volume 77, Issue 10, Page 1387-1393, October 2025.
Objective This study characterized the impact of voclosporin on kidney histology in patients with lupus nephritis (LN) who had protocolized repeat kidney biopsies in the AURORA clinical trials. Methods Patients were randomized to voclosporin or placebo treatment for up to 3 years; all patients received mycophenolate mofetil and low‐dose glucocorticoids.
Brad H. Rovin, Clarissa Cassol, Samir V. Parikh, Amit Saxena, Neil Solomons, Vanessa Birardi, Ernie Yap, Clint W. Abner, David R. W. Jayne, Robert B. Huizinga   +9 more
wiley   +1 more source

Effect of Acceptance and Commitment Therapy on Motivation and Adherence to Immunosuppressive Medication in Liver Transplant Recipients: A Randomized Controlled Trial

Brain and Behavior, Volume 15, Issue 10, October 2025.
A total of 140 liver transplant recipients were included in the experimental and control groups of this study. Recipients in the experimental group received eight sessions of acceptance and commitment therapy (ACT). Adherence to immunosuppressive medication and motivation increased in the ACT‐treated experimental group, while medication adherence ...
Serdar Saritas, Serafettin Okutan, Hasan Saritas, Semra Bulbuloglu   +3 more
wiley   +1 more source