Results 151 to 160 of about 109,035 (264)

Dad's legacy: Epigenetic reprogramming and paternal inflammatory memory in offspring health

Journal of Internal Medicine, Volume 298, Issue 1, Page 16-30, July 2025.
Abstract Over the past decade, numerous reports have highlighted intergenerational and even transgenerational epigenetic effects resulting from parental exposure to diets, toxins, and stress. In many cases, these parentally induced phenotypes do not seem to confer an obvious benefit, making it challenging to understand the evolutionary drivers behind ...
Shamila D. Alipoor, Parisa Norouzitallab, Anita Öst, Maria Lerm   +3 more
wiley   +1 more source

Development of a New AMBER Force Field for Cysteine and Histidine Cadmium‐Binding Proteins and Its Validation Through QM/MM MD Simulations

Journal of Computational Chemistry, Volume 46, Issue 16, June 15, 2025.
In the context of the AMBER parameterization, a new force field is developed and validated for the simulation of cadmium(II)‐binding proteins. The proposed force field takes into account the polarization effect produced by the central ion on its surroundings.
Matteo Orlandi, Marina Macchiagodena, Piero Procacci, Fabrizio Carta, Claudiu T. Supuran, Marco Pagliai   +5 more
wiley   +1 more source

Clot Burden As a Predictor of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism: A Cohort Study

Thoracic Research and Practice, 2023
Esmaeil Gharepapagh, Fatemeh Rahimi , Ata Koohi, Hooman Bakhshandeh, Seyed Ali Mousavi-Aghdas, Parham Sadeghipoor , Ashraf Fakhari, Mehrad Amirnia, Reza Javadrashid, Farid Rashidi   +9 more
doaj   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, Volume 12, Issue 21, June 5, 2025.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

Home-based HIV counseling and testing as a gateway to earlier initiation of antiretroviral therapy [PDF]

, 2011
Bakanda, Bakanda, Cohen, Corbett, Cullinan, De Cock, Decroo, Edward J. Mills, Faal, Ford, Grinsztejn, Human Rights Watch, Koenig, Kranzer, Kuwane, Maher, May, Miller, Mills, Muula, Nathan Ford, Phillips, Rosen, Severe, Sterne, Tumwesigye, Wachira, Were, Zachariah, Zachariah   +29 more
core   +2 more sources

Down syndrome in Africa: Challenges, opportunities, and future directions

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION As life expectancy improves for people with Down syndrome (DS) in Africa, the risk of developing DS‐associated Alzheimer's disease (DSAD) will rise. There is a pressing need to plan for this emerging challenge, particularly in the context of existing health and social disparities.
Eimear McGlinchey, Salina Tewolde, Amanda He, Juan Fortea, Lingani Mbakile‐Mahlanza, Ayda Tefera, Emmanuel Epenge, Jason Hassenstab, Alexander Jäck, Kirti Ranchod, Shaimaa El‐Jaafary, Johannes Levin, Mohamed Salama, Eric Rubenstein, Rufus Akinyemi, Tolulope Akinyemi, Temitope Farombi, Brian Lawlor, Jean Ikanga, Nicholas J. Ashton, Sarah Stout, Joyce Balls‐Berry, Atholl Valdon Kleinhans, Rachel Maina, Zul Merali   +24 more
wiley   +1 more source

Case Report: Extrapulmonary tuberculosis presenting as multiple caseous pericardial masses. [PDF]

Front Cardiovasc Med
Wang J, Zhang R, Li Z, Fang H, Zhang W.
europepmc   +1 more source

Bioactives From Brown Algae: Antioxidant, Anti‐Inflammatory, Anticancer, and Antimicrobial Potential

ChemBioEng Reviews, Volume 12, Issue 3, June 2025.
This review explores key bioactives in brown algae and their antioxidant, anti‐inflammatory, anticancer, and antimicrobial properties. Covering studies from 2014 to 2024, it highlights their relevance in pharmaceuticals, nutraceuticals, cosmetics, and foods, while addressing challenges and future directions to unlock their full potential.
Irvin Fonseca‐Barahona, Kaveh Shahbaz, Saeid Baroutian   +2 more
wiley   +1 more source

Anomalous Right Coronary Artery in the Setting of Active Tuberculosis: A Multidisciplinary Management Challenge. [PDF]

Life (Basel)
Peruničić A, Furtula M, Veljković S, Lakčević J, Šljivo A, Balint V, Tomić S, Vučinić S, Bojić M, Nikolić A.   +9 more
europepmc   +1 more source

Fibroblasts‐specific p16INK4a exacerbates inflammageing‐mediated post‐infarction ventricular remodelling through interacting with STAT3 to regulate NLRP3 transcription

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
In ageing fibroblasts, p16INK4a concurrently enhanced STAT3 di‐methylation mediated by EZH2 and suppressed the assembly of Bmi‐1‐EZH2/BCL‐6 complexes at the NLRP3 promoter region. These dual regulatory actions synergistically upregulated STAT3‐dependent NLRP3 transcription, thereby exacerbating inflammageing‐driven ventricular remodelling following ...
Xin Gu, Yingqiang Du, Jin'ge Zhang, Jiyu Li, Haiyun Chen, Yujie Lin, Yue Wang, Chunli Zhang, Shiyu Lin, Nannan Hao, Chengyi Peng, Jiacheng Ge, Jin Liu, Yan Liang, Yongjie Zhang, Xiaoyan Wang, Fang Wang, Jianliang Jin   +17 more
wiley   +1 more source