Results 161 to 170 of about 58,147 (226)

Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors

open access: yesChemistryOpen, Volume 14, Issue 10, October 2025.
This work investigates the selective inhibition of MAO enzymes by varying the substitution of electron‐withdrawing and donating groups on the phenyl rings of tetrahydropyridines (4 a–4 o). Compounds 4 l and 4 n exhibit promising IC50 values of 0.40±0.05 and 1.01±0.03 μM against MAO‐A and MAO‐B, respectively.
Obaid ur Rehman Khan   +10 more
wiley   +1 more source

Complications at Diagnosis of Pediatric Chronic Myeloid Leukemia in Chronic Phase

open access: yesPediatric Blood &Cancer, Volume 72, Issue 10, October 2025.
ABSTRACT Chronic myeloid leukemia (CML) is uncommon during the first two decades of life, resulting in limited experience of pediatricians in handling this leukemia. This is even more true when it comes to managing rare complications at the time of diagnosis.
Nirmalya Roy Moulik   +4 more
wiley   +1 more source

Global distribution of research efforts, disease burden, and impact of US public funding withdrawal. [PDF]

open access: yesNat Med
Schmallenbach L   +5 more
europepmc   +1 more source

An Unusual Initial Manifestation of Pulmonary Embolism: Aseptic Cavitary Infarction With Pulmonary Hypertension—Case Report and Literature Review

open access: yesRespirology Case Reports, Volume 13, Issue 10, October 2025.
We report a rare case of CTEPH presenting with an aseptic cavitary pulmonary infarction, an unusual manifestation typically mimicking infection or malignancy. This case underscores the need for genetic screening in unexplained CTEPH, as thrombophilia workup in our case revealed a heterozygous Factor V Leiden mutation (an uncommon congenital risk factor
Vinay Venugopal   +5 more
wiley   +1 more source

Mediastinal Cystic Teratoma in a Patient From Papua: A Rare Case Report

open access: yesRespirology Case Reports, Volume 13, Issue 10, October 2025.
This case report presents a mediastinal mature cystic teratoma, highlighting its clinical presentation, diagnostic approach, and management strategies to enhance awareness among clinicians. ABSTRACT Mediastinal teratomas are rare benign germ cell tumours that develop between the lungs, representing approximately 1%–5% of all mediastinal tumours.
Andika Chandra Putra   +5 more
wiley   +1 more source

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