Results 81 to 90 of about 790,262 (299)

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Risk Factors for False-Negative T-SPOT.TB Results in Bacteriologically Confirmed Pulmonary Tuberculosis: A Retrospective Cohort Study of 4,931 Patients

Infection and Drug Resistance
Muxing Chen,1 Yao Wang,2 Xiuping Chen,1 Xiaoqin Liao,1 Xueling Li,1 Di Wu,1 Xiaohong Chen,1 Jiandong Lin11Department of Tuberculosis, Fuzhou Pulmonary Hospital of Fujian Province, Fuzhou, Fujian, People’s Republic of China; 2Department of Laboratory ...
Chen M, Wang Y, Chen X, Liao X, Li X, Wu D, Chen X, Lin J   +7 more
doaj  

X-RAY MORPHOLOGICAL SEMIOTICS OF NON-TUBERCULOUS MYCOBACTERIAL PULMONARY DISEASE

Вестник рентгенологии и радиологии, 2018
Objective: to evaluate the X-ray radiological features of nontuberculous mycobacterial pulmonary disease (NTMPD) versus morphological findings.Material and methods.
R. B. Amansakhedov, L. N. Lepekha, L. I. Dmitrieva, I. Yu. Andrievskaya, A. T. Sigaev, N. N. Makar’yants, V. V. Romanov, A. E. Ergeshov   +7 more
doaj   +1 more source

1970 Tuberculosis Statistics : States And Cities [PDF]

In previous years, annual editions of \u201cReported Tuberculosis Data" presented detail and summary tables by geographic areas, and a review of tuberculosis statistics for the United States.

core  

Tuberculosis or not tuberculosis

Indian Journal of Medical Research, 2020
Muthu, Valliappan, Agarwal, Ritesh
openaire   +2 more sources

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Mycobacterium abscessus Cervical Lymphadenitis Mimicking Tuberculosis in China: A Case Report

International Medical Case Reports Journal
Can Guo,1,* Yu Guo,2,* Jing Tong,3,* Guizeng Zhao,1 Linyan Yao,1 Yanjing Pan,1 Min Zang,1 Kewei Liu3 1Department of Tuberculosis, The First Affiliated Hospital of Henan Medical University, Xinxiang, People’s Republic of China ...
Guo C, Guo Y, Tong J, Zhao G, Yao L, Pan Y, Zang M, Liu K   +7 more
doaj  

The clinical case of effective treatment of pulmonary tuberculosis in the female adolescent after kidney transplantation

Туберкулез и болезни лёгких, 2016
The article presents the clinical case of successful treatment of pulmonary tuberculosis in the female adolescent with concurrent chronic kidney disease.
E. S. Ovsyankina, N. L. Karpina, F. G. Poluehktova, O. V. Kasimtseva, S. G. Mikhaylov, A. Eh. Ergeshov   +5 more
doaj