Results 71 to 80 of about 1,119,938 (307)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

1973 Tuberculosis Statistics : States And Cities [PDF]

Tuberculosis morbidity and mortality data and information on hospital facilities are completed at various times throughout the year. In order to provide information as early as possible, tuberculosis statistics are published as data become available ...

core  

Pulaski County Tuberculosis Association records [PDF]

, 1919
This small collection contains minutes of the Pulaski County Tuberculosis Association meetings from 1919-1929.
Pulaski County Tuberculosis Association. (Little Rock, Ark.)
core  

A prospective blood RNA signature for tuberculosis disease risk

The Lancet, 2016
Background Identification of blood biomarkers that prospectively predict progression of Mycobacterium tuberculosis infection to tuberculosis disease may lead to interventions that impact the epidemic. Methods Healthy, M.
Daniel E. Zak, A. Penn-Nicholson, T. Scriba, E. Thompson, S. Suliman, L. Amon, H. Mahomed, Mzwandile Erasmus, Wendy E. Whatney, G. Hussey, D. Abrahams, F. Kafaar, T. Hawkridge, S. Verver, E. Hughes, M. Ota, J. Sutherland, R. Howe, H. Dockrell, W. Boom, B. Thiel, T. Ottenhoff, H. Mayanja-Kizza, A. Crampin, K. Downing, M. Hatherill, Joe Valvo, Smitha Shankar, S. Parida, S. Kaufmann, G. Walzl, A. Aderem, W. Hanekom   +32 more
semanticscholar   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

1972 Tuberculosis Statistics : States And Cities [PDF]

Tuberculosis morbidity and mortality data and information on hospital facilities are completed at various times throughout the year. In order to provide ^formation as early as possible, tuberculosis statistics are published as data become available. This

core  

Phase 2b placebo-controlled trial of M72/AS01E candidate vaccine to prevent active tuberculosis in adults

New England Journal of Medicine, 2018
BACKGROUND A vaccine to interrupt the transmission of tuberculosis is needed. METHODS We conducted a randomized, double‐blind, placebo‐controlled, phase 2b trial of the M72/AS01E tuberculosis vaccine in Kenya, South Africa, and Zambia.
Olivier Van Der Meeren, M. Hatherill, V. Nduba, R. Wilkinson, M. Muyoyeta, Elana van Brakel, H. Ayles, G. Henostroza, Friedrich Thienemann, T. Scriba, A. Diacon, G. Blatner, M. Demoitié, M. Tameris, M. Malahleha, J. Innes, Elizabeth Hellström, N. Martinson, T. Singh, E. J. Akité, Aisha Khatoon Azam, A. Bollaerts, A. Ginsberg, T. Evans, P. Gillard, D. Tait   +25 more
semanticscholar   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Tuberculosis : general information [Russian] [PDF]

Tuberculosis : general information [Russian]CS227840_ATB-Elimination-Russian ...

core  

Mycobacterium tuberculosis Beijing genotype. [PDF]

, 2003
Molecular epidemiologic studies of strains of Mycobacterium tuberculosis are currently conducted worldwide. The genetically distinct Beijing family of strains has been associated with large outbreaks of tuberculosis, increased virulence, and multidrug ...
Lillebaek, Troels, Judith R. Glynn, Andersen, Åse B., Troels Lillebaek, Glynn, Judith R., Kremer, Kristin, Åse B. Andersen, Asger Dirksen, Kristin Kremer, Andersen, Ase B, Glynn, Judith R, Dirksen, Asger   +11 more
core   +1 more source