Results 51 to 60 of about 1,119,938 (307)

Pulmonary Tuberculosis among People Living with HIV/AIDS Attending Care and Treatment in Rural Northern Tanzania. [PDF]

, 2008
Tuberculosis is the commonest opportunistic infection and the number one cause of death in HIV/AIDS patients in developing countries. To address the extent of the tuberculosis HIV coinfection in rural Tanzania we conducted a cross sectional study ...
Odd Morkve, Mfinanga, Sayoki Godfrey, Sayoki G Mfinanga, Bernard J Ngowi, Morkve Odd, Ngowi, Bernard J, Ngowi, Bernard J., Mfinanga Sayoki G, Bruun, Johan Nikolai, Mørkve, Odd, Mfinanga, Sayoki G, Johan N Bruun, Bruun Johan N, Morkve, Odd, Bruun, Johan N, Ngowi Bernard J   +15 more
core   +1 more source

An Interferon-Inducible Neutrophil-Driven Blood Transcriptional Signature in Human Tuberculosis

Nature, 2010
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment.
M. Berry, C. Graham, Finlay W Mcnab, Zhaohui Xu, S. Bloch, T. Oni, K. Wilkinson, R. Banchereau, Jason A. Skinner, R. Wilkinson, Charlie Quinn, D. Blankenship, R. Dhawan, J. Cush, A. Mejías, O. Ramilo, O. Kon, V. Pascual, J. Banchereau, D. Chaussabel, A. O’Garra   +20 more
semanticscholar   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Tuberculosis and pregnancy Spanish [PDF]

"Para una mujer embarazada y su criatura, la tuberculosis no tratada constituye un riesgo mayor que el propio tratamiento. Las mujeres embarazadas deben comenzar a tratarse cuando su probabilidad de tener tuberculosis sea de moderada a elevada.
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.) Division of Tuberculosis Elimination.
core  

Multidrug-resistant tuberculosis. [PDF]

, 2008
BACKGROUND: With almost 9 million new cases each year, tuberculosis remains one of the most feared diseases on the planet. Led by the STOP-TB Partnership and WHO, recent efforts to combat the disease have made considerable progress in a number of ...
Zager, Ellen M, McNerney, Ruth
core   +1 more source

The global tuberculosis epidemic and progress in care, prevention, and research: an overview in year 3 of the End TB era.

The Lancet Respiratory Medicine, 2018
Tuberculosis is the number one cause of death from infectious disease globally and drug-resistant forms of the disease are a major risk to global health security. On the occasion of World Tuberculosis Day (March 24, 2018), we provide an up-to-date review
K. Floyd, P. Glaziou, Alimuddin Zumla, M. Raviglione   +3 more
semanticscholar   +1 more source

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Xpert MTB/RIF and Xpert MTB/RIF Ultra for pulmonary tuberculosis and rifampicin resistance in adults

Cochrane Database of Systematic Reviews, 2019
Background Xpert MTB/RIF (Xpert MTB/RIF) and Xpert MTB/RIF Ultra (Xpert Ultra), the newest version, are the only World Health Organization (WHO)‐recommended rapid tests that simultaneously detect tuberculosis and rifampicin resistance in persons with ...
D. Horne, Mikashmi Kohli, J. S. Zifodya, I. Schiller, N. Dendukuri, D. Tollefson, S. Schumacher, E. Ochodo, M. Pai, K. Steingart   +9 more
semanticscholar   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source