Results 31 to 40 of about 1,119,938 (307)

Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez, Monica Ferrer Socorro, Kathryn Yang, Nicole Battaglia, Zainab Zaman, Mariko Bennett, Adeline Vanderver, Pui Y. Lee, Lauren A. Henderson, Milena M. Andzelm, Darius Ebrahimi‐Fakhari   +10 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

The Case of a 40‐Year‐Old Man With New‐Onset Status Epilepticus in the Setting of HIV Infection

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 40‐year‐old man from Andhra Pradesh in India, while on regular antiretroviral treatment (ART) for long‐standing HIV infection presented with a 1‐day history of new‐onset status epilepticus. CT and MRI brain showed multifocal cerebral ring lesions, some of which demonstrated characteristic ‘hole‐with‐a‐dot’ sign.
Vadde Akhil, Ramachandiran Nandhagopal
wiley   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Efficient Deep Network Architectures for Fast Chest X-Ray Tuberculosis Screening and Visualization

Scientific Reports, 2019
Automated diagnosis of tuberculosis (TB) from chest X-Rays (CXR) has been tackled with either hand-crafted algorithms or machine learning approaches such as support vector machines (SVMs) and convolutional neural networks (CNNs). Most deep neural network
F. Pasa, Vladimir Golkov, F. Pfeiffer, D. Cremers, D. Pfeiffer   +4 more
semanticscholar   +1 more source

[WHO Guidelines on Tuberculosis Infection Prevention and Control].

Das Gesundheitswesen, 2020
BACKGROUND Despite considerable progress in the fight against tuberculosis, it is still the most deadly bacterial infectious disease worldwide. Every year, up to 10 million people worldwide still die of tuberculosis.
C. Christof, B. Nussbaumer-Streit, G. Gartlehner   +2 more
semanticscholar   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

The timing of death in patients with tuberculosis who die during anti-tuberculosis treatment in Andhra Pradesh, South India [PDF]

, 2011
Background: India has 2.0 million estimated tuberculosis (TB) cases per annum with an estimated 280,000 TBrelated deaths per year. Understanding when in the course of TB treatment patients die is important for determining the type of intervention to be ...
Tetali, S, Harries Anthony D, Rao Srinivas, Jonnalagada, Subbanna, Kannuri, Nanda K, Peri, Sundaresh, Kannuri, N K, Srinath Satyanarayana, Peri, S, Peri Sundaresh, Harries, Anthony D, Anchala, Raghupathy, Zachariah Rony, Anchala Raghupathy, Ranganadha Rao, Jonnalagada, S, Rao Ranganadha, Rao, Ranganadha, Jonnalagada Subbanna, Nanda K Kannuri, Zachariah, Rony, Rao, Srinivas, Harries, A D, Rao, S, Shailaja Tetali, Rao, R, Satyanarayana Srinath, Tetali Shailaja, Anthony D Harries, Satyanarayana, Srinath, Zachariah, R, Tetali, Shailaja, Anchala, R, Kannuri Nanda K, Satyanarayana, S, Keshav Chander, G, G Keshav Chander, Keshav Chander G, Sundaresh Peri, Raghupathy Anchala, Subbanna Jonnalagada, Rony Zachariah, Srinivas Rao   +42 more
core   +2 more sources

The Immune Escape Mechanisms of Mycobacterium Tuberculosis

International Journal of Molecular Sciences, 2019
Epidemiological data from the Center of Disease Control (CDC) and the World Health Organization (WHO) statistics in 2017 show that 10.0 million people around the world became sick with tuberculosis.
Weijie Zhai, Fengjuan Wu, Yiyuan Zhang, Yurong Fu, Zhijun Liu   +4 more
semanticscholar   +1 more source