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Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut-lung axis. [PDF]

open access: yesNat Immunol, 2022
Aside from centrally induced trained immunity in the bone marrow (BM) and peripheral blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate immune memory can develop via a local inflammatory pathway following ...
Jeyanathan M   +15 more
europepmc   +2 more sources

Association of BCG Vaccine Treatment With Death and Dementia in Patients With Non-Muscle-Invasive Bladder Cancer.

open access: yesJAMA Netw Open, 2023
Key Points Question Does the BCG vaccine have a protective association with the risk of Alzheimer disease and related dementias (ADRD)? Findings In this cohort study of 6467 patients with non–muscle-invasive bladder cancer, treatment with intravesical ...
Weinberg MS   +12 more
europepmc   +2 more sources

The BCG Vaccine for COVID-19: First Verdict and Future Directions

open access: yesFrontiers in Immunology, 2021
Despite of the rapid development of the vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it will take several months to have enough doses and the proper infrastructure to vaccinate a good proportion of the world ...
Maria Gonzalez-Perez   +6 more
doaj   +2 more sources

BCG Vaccine-The Road Not Taken. [PDF]

open access: yesMicroorganisms, 2022
The Bacillus Calmette-Guérin (BCG) vaccine has been used for over one hundred years to protect against the most lethal infectious agent in human history, tuberculosis. Over four billion BCG doses have been given and, worldwide, most newborns receive BCG.
Dow CT, Kidess L.
europepmc   +4 more sources

Genomic characteristics of two most widely used BCG vaccine strains: Danish 1331 and Pasteur 1173P2 [PDF]

open access: yesBMC Genomics, 2022
Background Bacillus Calmette–Guérin (BCG) refers to a group of vaccine strains with unique genetic characteristics. BCG is the only available vaccine for preventing tuberculosis (TB).
Mahla Asadian   +3 more
doaj   +2 more sources

Prospects in Mycobacterium bovis Bacille Calmette et Guérin (BCG) vaccine diversity and delivery: Why does BCG fail to protect against tuberculosis?

open access: yesVaccine, 2015
Mycobacterium tuberculosis (M.tb) infection leads to active tuberculosis (TB), a disease that kills one human every 18 seconds. Current therapies available to combat TB include chemotherapy and the preventative vaccine Mycobacterium bovis Bacille ...
Jordi Torrelles   +2 more
exaly   +2 more sources

Culture filtrate proteins from BCG act as adjuvants for cytotoxic T lymphocyte induction

open access: yesFrontiers in Immunology, 2023
Mycobacterium bovis bacilli Calmette-Guerin (BCG) is a licensed vaccine against tuberculosis. It requires attenuated live bacteria to be effective, possibly because actively secreted proteins play a critical role in inducing anti-tuberculosis immunity ...
Satoru Mizuno   +7 more
doaj   +1 more source

TUBERCULIN RESPONSE AND SCAR FORMATION IN BCG VACCINATED 7-YEARS OLD SCHOOLCHILDREN IN SOFIA, BULGARIA [PDF]

open access: yesJournal of IMAB, 2015
This study has been designed to evaluate safety and efficacy of BCG vaccine in school-entering children in terms of tuberculin response to PPD and scar formation as indicators for successful vaccination.
Tzvetelina Stefanova
doaj   +1 more source

A place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccine

open access: yesVaccine, 2021
The BCG vaccine has long been recognized for reducing the risk to suffer from infectious diseases unrelated to its target disease, tuberculosis. Evidence from human trials demonstrate substantial reductions in all-cause mortality, especially in the first
Byron Brook   +4 more
semanticscholar   +1 more source

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