Results 11 to 20 of about 178,050 (257)

Tuberculous meningitis

open access: yesClinical Case Reports, 2023
Tuberculous meningitis is possibly complicated with multiple cerebral infarctions and basal meningitis, and the mortality and neurological prognosis is reportedly poor.
Shinnosuke Fukushima   +4 more
doaj   +4 more sources

Tuberculous Meningitis in Children: Reducing the Burden of Death and Disability

open access: yesPathogens, 2021
Tuberculous meningitis disproportionately affects young children. As the most devastating form of tuberculosis, it is associated with unacceptably high rates of mortality and morbidity even if treated.
Julie Huynh   +5 more
doaj   +2 more sources

Treatment of Tuberculous Meningitis [PDF]

open access: greenThe Lancet, 1953
The incidence of tuberculous meningitis is at last rapidly diminishing in this country, yet in 1958 there were still 369 newly notified cases in England and Wales (Ministry of Health, 1959). As the untreated disease is inevitably fatal, this incidence is still an important therapeutic challenge.
J. G. Kerr
openalex   +6 more sources

The pathogenesis of tuberculous meningitis [PDF]

open access: yesJournal of Leukocyte Biology, 2019
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality
A. Davis   +4 more
semanticscholar   +4 more sources

Tuberculous meningitis [PDF]

open access: yesMedicine, 2013
Tuberculous meningitis (TBM) is caused by Mycobacterium tuberculosis and kills or disables around a half of sufferers. It is commonest in young children and those infected with HIV, but can affect all age-groups. TBM presents with non-specific symptoms over days or weeks, followed by worsening headaches, fever, and vomiting.
Van, T, Farrar, J
  +7 more sources

Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults

open access: yesNew England Journal of Medicine, 2023
Background Adjunctive corticosteroids are widely used to treat HIV-associated tuberculous meningitis despite limited data supporting their safety and efficacy. Methods We conducted a randomized double-blind placebo-controlled trial in HIV-positive adults
Joseph Donovan   +29 more
semanticscholar   +1 more source

Predominance of Escherichia-Shigella in Gut Microbiome and Its Potential Correlation with Elevated Level of Plasma Tumor Necrosis Factor Alpha in Patients with Tuberculous Meningitis

open access: yesMicrobiology spectrum, 2022
As the most severe form of tuberculosis, the pathogenesis of tuberculous meningitis (TBM) is still unclear. Gut microbiota dysbiosis plays an important role in a variety of central nervous system diseases.
Shanshan Li   +11 more
semanticscholar   +1 more source

High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis

open access: yesJournal of Clinical Investigation, 2022
Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality.
Camilo A. Ruiz-Bedoya   +15 more
semanticscholar   +1 more source

Improving Technology to Diagnose Tuberculous Meningitis: Are We There Yet?

open access: yesFrontiers in Neurology, 2022
Diagnosis of tuberculous meningitis (TBM) remains challenging due to a paucity of high-performance diagnostics. Even those that have reasonable sensitivity are not adequate to ‘rule out' TBM.
K. Ssebambulidde   +4 more
semanticscholar   +1 more source

The global burden of tuberculous meningitis in adults: A modelling study

open access: yesPLOS Global Public Health, 2021
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis. The incidence and mortality of TBM is unknown due to diagnostic challenges and limited disaggregated reporting of treated TBM by existing surveillance systems. We aimed to estimate the
P. Dodd   +9 more
semanticscholar   +1 more source

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