Results 111 to 120 of about 347,356 (359)

TUBEROUS SCLEROSIS, CRITERIA FOR DIAGNOSTICS: CLINICAL CASE

Вісник проблем біології і медицини, 2018
Tuberous sclerosis (Bourneville disease) is a genetic disease with an amount number of multiorganically development of hamartomas (benign tumors) that are slowly progressing, increasing in size and violating the functions of these organs.
Kryvchun A. M.
doaj   +1 more source

Meta-analysis of stomatitis in clinical studies of everolimus: incidence and relationship with efficacy. [PDF]

, 2016
BackgroundEverolimus, an oral mammalian target of rapamycin (mTOR) inhibitor, is used to treat solid tumors and tuberous sclerosis complex (TSC). Stomatitis, an inflammation of the mucous membranes of the mouth, is a common adverse event associated with ...
Anak, O, Franz, D, Gallo, J, Hortobagyi, GN, Motzer, R, Pavel, M, Ravaud, A, Ringeisen, F, Rouyrre, N, Rugo, HS, Yao, J   +10 more
core  

Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]

, 2017
A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Abraham, Abs, Akin, Aronica, Aronica, Ashraf, Auvin, Bar-Klein, Basler, Bhala, Bozzi, Cacheaux, Cerri, Citraro, Dianzani, Diaz-Hernandez, Dityatev, Drion, Engel, Fabene, Friedman, Fu, Fukasawa, Galanopoulou, Ganesh, Gorter, Groettrup, Groettrup, He, Heinemann, Henshall, Holtman, Huang, Iori, Iyer, Jiang, Jimenez-Pacheco, Jimenez-Pacheco, Jung, Kim, Kim, Kwon, Liang, Liepe, Louboutin, Louboutin, Marchi, Maroso, Maroso, Marusich, McRae, Mishto, Mishto, Mishto, Mishto, Mishto, Noe, Nomura, O'Neill, Podojil, Polascheck, Pollock, Prabowo, Quan, Ravizza, Ravizza, Rojas, Rojas, Rojas, Rojas, Roseti, Roseti, Ruden, Sadowski, Scheppingen, Scheppingen, Serrano, Takenouchi, Thalhammer, Varvel, Vezzani, Vezzani, Vezzani, Vezzani, Vezzani, Vliet, Vliet, Volonte, Vries, Wei, Zanker, Zeng, Zhang   +92 more
core   +4 more sources

Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations.

Pediatric Neurology, 2021
MD a Hope Northrup, MD Mary E. Aronow, MD E. Martina Bebin, MD John Bissler, MD PhD e Petrus Thomas N. Darling, MBChB MRCPsych PhD J. de Vries, MD g Zo Michael D. Frost, Fuchs, D. M. I. Elizabeth S. Gosnell, MD j Nishant Gupta, MD PhD k Sergiusz Anna C. Jansen, MSc J. Chris Kingswood, MD Timothy K. Knilans, MD o Francis X. McCormack, Msn Ashley Pounders, PhD Steven L. Roberds, MD p David F. Rodriguez-Buritica, MD Jonathan Roth, DM Julian R. Sampson, MD s Steven Sparagana, MD PhD Elizabeth Anne Thiele, MD Howard L. Weiner, MD v James W. Wheless, MD Alexander J. Towbin, M. P. Darcy A. Krueger, Darcy Krueger, N. M. P. Annear, Ute Bartels, Moncef Berhouma, Klemens Budde, A. Byars, Harry Chugani, Edward W. Cowen, Peter B Crino, Paolo Curatolo, Petrus de Vries, Daniel F. Dilling, David W. Dunn, Rosmary Ekong, K. Ess, D. N. Franz, D. B. Fuchs, Lisa Guay-Woodford, Luciana Haddad, Anne Halbert, Adelaide A. Hebert, E. Henske, Gregory L. Holmes, Dena Hook, John Hulbert, Sergiusz Simon R. Johnson, J. O. zwiak, Bryan King, Mary Kay Koenig, Bruce Korf, David J. Kwiatkowski, Joel Moss, David Mowat, Kate Mowrey, R. Nabbout, M. Nellist, Finbar O'Callaghan, Uday Patel, E. Roach, Robb Romp, Micaela Rozenberg, Stephen J. Ruoss, Mustafa Sahin, Joshua A. Samuels, Matthias Sauter, Catherine Smith, Keyomaurs Soltani, Shoba Srivastava, Clare Stuart, Joyce M. C. Teng, Andrew Trout, A. V. Eeghen, S. Vanclooster, Henry Z. Wang, Mari Wataya-Kaneda, Patricia Witman, Tim Wright, Joyce Y. Wu   +82 more
semanticscholar   +1 more source

Cognitive outcomes after deep brain stimulation in drug‐resistant epilepsy: A comparison of anterior thalamic and hippocampal stimulation

Epilepsia Open, EarlyView.
Abstract Objective Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) and hippocampus is an emerging therapy for drug‐resistant epilepsy (DRE) when resective surgery is not feasible. We aimed to evaluate the long‐term cognitive outcomes of these two DBS targets, hypothesizing that both interventions preserve cognitive function ...
Seonjeong Kim, Semina Jung, Seunghoon Lee, Eun Yeon Joo, Dae‐Won Seo, Young‐Min Shon   +5 more
wiley   +1 more source

Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDAC) is generally a fatal disease with no efficacious treatment modalities. Elucidation of signaling mechanisms that will lead to the identification of novel targets for therapy and chemoprevention is urgently needed ...
Eibl, Guido, Rozengurt, Enrique, Sinnett-Smith, James   +2 more
core   +2 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Tuberous sclerosis‐associated neuropsychiatric disorders: a paediatric cohort study

Developmental Medicine & Child Neurology, 2018
We aimed to study tuberous sclerosis‐associated neuropsychiatric disorders (TAND) in children and adolescents with tuberous sclerosis complex (TSC).
I. Toldo, Valeria Brasson, M. Miscioscia, M. Pelizza, R. Manara, S. Sartori, Giulia Mantegazza, Marilena Vecchi, M. Nosadini, M. Gatta   +9 more
semanticscholar   +1 more source

Lymphangioleiomyomatosis and tuberous sclerosis

Respiratory Medicine, 2002
Tuberous sclerosis (TSC) is an inherited disorder best known for its association with severe learning difficulties, epilepsy, behavioural problems, skin and renal pathology Lymphangioleiomyomatosis (LAM), characterized by alveolar smooth muscle proliferation and cystic destruction of parenchyma, occurs as an infrequent symptomatic pulmonary ...
Julian R. Sampson, E. Hancock, S. Tomkins, John P. Osborne   +3 more
openaire   +3 more sources

Unusual adult-onset cardiac rhabdomyomas in tuberous sclerosis complex: a case report

Frontiers in Medicine
BackgroundTuberous sclerosis complex is a genetic neurocutaneous autosomal dominant syndrome, characterized by the development of multiple benign tumors (hamartomas) affecting various systems.
H. A. Nati-Castillo, Juan Manuel Quintero, Oswaldo Aguilar Molina, Marlon Arias-Intriago, Fernando P. Melgar Muñoz, Juan S. Izquierdo-Condoy   +5 more
doaj   +1 more source