Results 171 to 180 of about 42,064 (302)

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

, 2003
Andrew R. Tee, Brendan D. Manning, Philippe P. Roux, Lewis C. Cantley, John Blenis   +4 more
openalex   +1 more source

Mechanisms of Epileptogenesis in Tuberous Sclerosis Complex and Related Malformations of Cortical Development with Abnormal Glioneuronal Proliferation [PDF]

, 2007
Michael Wong
openalex   +1 more source

A Phase 1/2 Study of Lenvatinib in Combination With Everolimus in Recurrent and Refractory Pediatric and Young Adult Solid Tumors

Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT Introduction Developing targeted therapies with manageable toxicities remains a high priority for pediatric cancer. We sought to determine the recommended Phase 2 dose (RP2D) and evaluate the antitumor activity of lenvatinib+everolimus in children/young adults with select recurrent/refractory solid tumors.
Filemon S. Dela Cruz, Elizabeth Fox, Steven G. DuBois, Gregory K. Friedman, James M. Croop, AeRang Kim, Daniel A. Morgenstern, Frank M. Balis, Margaret E. Macy, Joseph G. Pressey, Tanya Watt, Julie I. Krystal, Kieuhoa T. Vo, Rajen Mody, Theodore W. Laetsch, Brenda J. Weigel, Karen O'Hara, Cixin S. He, Jagadeesh Aluri, Chinyere E. Okpara, Julia L. Glade Bender   +20 more
wiley   +1 more source

Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex [PDF]

, 2007
Linghui Zeng, Yannan Ouyang, Vered Gazit, John R. Cirrito, Laura A. Jansen, Kevin C. Ess, Kelvin A. Yamada, David F. Wozniak, David M. Holtzman, David H. Gutmann, Michael Wong   +10 more
openalex   +1 more source

Whey Protein Mitigates Oxidative Stress Injury and Improves Protein Synthesis in Mouse Skeletal Muscle by Regulating the SIRT1/Nrf2/HO‐1 Axis and AMPK/TSC2/mTOR/4EBP1 Pathway

Journal of Food Science, Volume 90, Issue 7, July 2025.
ABSTRACT Whey protein (WP) can improve muscle mass and strength. However, its effects and underlying molecular mechanism in promoting recovery from muscle damage caused by excessive physical exercise remains unknown. Therefore, the present study aimed to investigate the therapeutic effect of WP on skeletal muscle injury caused by exogenous oxidants and
Guangqi Li, Liying Shang, Xin Wang, Lequn Zhang, Yuchu Zhao, Weifeng Ni, Xueyuan Bai, Junyi Liu   +7 more
wiley   +1 more source

Fetal rhabdomyoma: Prenatal diagnosis, clinical outcome, and incidence of associated tuberous sclerosis complex

, 2003
Rima S. Bader, David Chitayat, Edmond Kelly, Greg Ryan, Jeffrey Smallhorn, Lisa K. Hornberger   +5 more
openalex   +1 more source

Tuberous Sclerosis Complex: from basic science to clinical phenotypes [PDF]

, 2007
Paolo Curatolo
openalex   +1 more source

TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts

Aging Cell, Volume 24, Issue 7, July 2025.
TFEB dynamics during oxidative stress‐induced premature senescence. The tBHP treatment undermines GSH‐dependent antioxidant mechanisms, leading to increased ROS production and lysosomal damage. In the stress phase, we observed the concomitant inhibition of Akt along with activation of AMPK, together leading to mTOR inhibition and subsequent ...
Lena Guerrero‐Navarro, Pablo Monfort‐Lanzas, Vinzenz Krichbaumer, Mariana E. G. De Araújo, Jlenia Monfregola, Lukas A. Huber, Andrea Ballabio, Pidder Jansen‐Dürr, Maria Cavinato   +8 more
wiley   +1 more source

The Multifaceted Nature of Tuberous Sclerosis Complex. [PDF]

Sultan Qaboos Univ Med J
Khan SA, Baig A, Riyami D.
europepmc   +1 more source