Results 171 to 180 of about 46,855 (284)
Biomedical Chromatography, Volume 40, Issue 3, March 2026.ABSTRACT Bexicaserin is an investigational molecule that is a highly selective superagonist of the 5‐hydroxytryptamine 2C (5HT2c) serotonin receptor subtype and in Phase 3 clinical studies for the treatment of seizures associated with developmental and epileptic encephalopathies (DEEs).
Raja Reddy Kallem +5 more
wiley +1 more source
Everolimus induced organizing pneumonia in a patient with tuberous sclerosis complex
, 2021 Julio Lanfranco +5 more
openalex +1 more source
Brain Pathology, Volume 36, Issue 2, March 2026.Deep learning tissue mapping can guide region of interest selection for spatial transcriptomic analyses. Using this method, a transcriptional catalogue of focal cortical dysplasia type IIb was generated, revealing enrichment for markers of inhibitory glycinergic signaling in cytomegalic dysmorphic neurons.
Ameesha Paliwal +8 more
wiley +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.ABSTRACT Purpose Infants with cancer are rare and face unique challenges. Our study aims to describe the incidence of infantile cancers in Canada and to compare treatment‐related mortality (TRM) and their outcomes with those of older children. Methods We conducted a retrospective cohort study using the Cancer in Young People in Canada database ...
Samuel Sassine +22 more
wiley +1 more source
Biomedical Chromatography, Volume 40, Issue 2, February 2026.ABSTRACT The investigational molecule bexicaserin is a highly selective 5‐HT2C superagonist currently in Phase 3 clinical studies for the treatment of seizures associated with developmental and epileptic encephalopathies (DEEs). To facilitate its clinical development, a simple LC–MS/MS method was developed and validated for the quantitative estimation ...
Raja Reddy Kallem +5 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 2, February 2026.Encouraging survival is achieved in phakomatosis syndromes with conventional multimodality treatment (Surgery, RT, chemotherapy). There is an urgent need for easily administered systemic therapies which improve both quality and quantity of life. ABSTRACT Purpose Phakomatoses‐associated primary central nervous system (CNS) tumors are therapeutically ...
Anuradha Krishnan +10 more
wiley +1 more source
Clinical features and genetic analysis of tuberous sclerosis pedigrees
Chinese Journal of Contemporary Neurology and Neurosurgery, 2012 Objective In order to understand tuberous sclerosis complex better, the clinical manifestation, imaging characteristics, and genetic characteristics of tuberous sclerosis complex from 3 pedigrees were investigated.
Ya⁃qin LI +11 more
doaj
Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention
Cancer Medicine, Volume 15, Issue 2, February 2026.Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa +4 more
wiley +1 more source
Cell Biology International, Volume 50, Issue 2, February 2026.ABSTRACT Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction
Lanlan Bai +12 more
wiley +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 2, February 2026.Cannabidiol and cannabigerol suppress maximal electroshock seizures. Cannabidiol and cannabigerol show similar dose–response properties. Both cannabinoids show no toxicity at effective doses. ABSTRACT Current antiseizure therapy for epilepsy is only effective in about 70% of the patient population.
Han Zhong Zhou +3 more
wiley +1 more source