Tsc1 regulates tight junction independent of mTORC1 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The epithelium barrier is vital for sealing body surface and alimentary spaces, preventing paracellular material diffusion and pathogen invasion. We describe here that tuberous sclerosis complex 1 (Tsc1) controls tight junction (TJ) formation to create and maintain the epithelial barrier, independent of its conventional role in ...
Zelong Han, Ling Zhou, Zeyou Qiu
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Tsc1 is a Critical Regulator of Macrophage Survival and Function [PDF]
Cellular Physiology and Biochemistry, 2015 Background/Aims: Tuberous sclerosis complex 1 (Tsc1) has been shown to regulate M1/M2 polarization of macrophages, but the precise roles of Tsc1 in the function and stability of macrophages are not fully understood. Here we show that Tsc1 is required for
Chunmin Fang +12 more
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Structure of the TBC1D7–TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region [PDF]
Journal of Molecular Cell Biology, 2016 TSC1 and TSC2 mutations account for the majority of tuberous sclerosis complex cases. The TSC1 and TSC2 proteins assemble into a complex that is stabilized by TBC1D7 through its direct interaction with the TSC1 coiled coil (CC) region. Loss of TBC1D7 is associated with intellectual disability and megalencephaly. Here, we determine the crystal structure
Zhongchao Gai, Mark Nellist, Geng Wu
exaly +4 more sources
Lung mTOR activation leads to lung fibrosis or emphysema via senescence of specific lung cells [PDF]
Scientific ReportsExaggerated cellular senescence contributes to pulmonary emphysema and fibrosis, yet the mechanisms driving these distinct disease phenotypes remain poorly understood.
A. Houssaini +17 more
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In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis [PDF]
Orphanet Journal of Rare DiseasesBackground Tuberous sclerosis complex (TSC) is a rare genetic neurocutaneous disorder resulting from mutations in the TSC1 or TSC2 genes, characterized by overgrowth and lesions in multiple organs.
Julika E. Friedrich +13 more
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Identification of a region required for TSC1 stability by functional analysis of
BMC Medical Genetics, 2009 Background Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterised by the development of hamartomas in a variety of organs and tissues.
den Dunnen Johan T +9 more
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The critical role of the proto-oncogene c-Kit in TSC renal cystogenesis [PDF]
EMBO Molecular MedicineThe epithelium of kidney cysts in mouse Tuberous Sclerosis complex (TSC) models and TSC patients is composed of proliferating A-intercalated cells. The ablation of the Foxi1 gene abolished renal cystogenesis in principal cell-specific Tsc1 knockout (Tsc1-
Kamyar Zahedi +6 more
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Uncomplexed-TSC1 deploys novel mTORC1-independent pathway to exacerbate the liver glycogen storage in TSC [PDF]
Cell Death and DiseaseTuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by inactivating mutations in TSC1 or TSC2 gene, leading to mTORC1 hyperactivation. However, mTORC1-independent mechanisms in this disorder remain poorly understood.
Xiaoqiao Yue +9 more
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TSC1 deficiency drives immune evasion in colorectal cancer via mTORC1-mediated dysregulation of PD-L1 sialylation [PDF]
Frontiers in ImmunologyBackgroundTSC1 serves as a critical regulator of the mTORC1 signaling pathway with established roles in colorectal cancer pathogenesis. This investigation systematically examined the clinical relevance of TSC1 in colorectal cancer and its mechanistic ...
Xuemei Guan +4 more
doaj +2 more sources
p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway
Cell Stress, 2021 Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (
Clarissa Braun +6 more
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