Results 1 to 10 of about 2,989,296 (301)

Tumor suppressor p53 cross-talks with TRIM family proteins

Genes and Diseases, 2021
p53 is a key tumor suppressor. As a transcription factor, p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor ...
Juan Liu, Cen Zhang, Xue Wang, Wenwei Hu, Zhaohui Feng   +4 more
doaj   +3 more sources

VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles

Biology, 2021
Guanosine nucleotide exchange factors (GEFs) are responsible for catalyzing the transition of small GTPases from the inactive (GDP-bound) to the active (GTP-bound) states. RHO GEFs, including VAV proteins, play essential signaling roles in a wide variety
Myriam Cuadrado, Javier Robles-Valero
doaj   +3 more sources

Computational screening of oncogenic genetic variations in tumor suppressor proteins driving gastric cancer pathogenesis. [PDF]

PLoS ONE
Gastric cancer (GC) is currently the fifth most common cancer globally, often driven by dysregulation of tumor suppressor pathways. While individual studies on genetic variations of proteins are common, a comprehensive systems-level analysis of proteins ...
Faria Ferdouse Mim, Taslima Akter Sumiya, Roksana Khanam, Jannati Akter, Farhana Arzu, Samia Haque, Md Roman Miah, K M Tanjida Islam, Shahin Mahmud   +8 more
doaj   +2 more sources

White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy [PDF]

Cancers, 2022
Peter Habenberger, Michael Rose, Edgar Dahl   +2 more
exaly   +2 more sources

The Rosetta Stone Hypothesis-Based Interaction of the Tumor Suppressor Proteins Nit1 and Fhit [PDF]

Cells, 2023
Sebastian Y Müller, Otmar Huber
exaly   +2 more sources

A Perspective on Therapeutic Targeting Against Ubiquitin Ligases to Stabilize Tumor Suppressor Proteins [PDF]

Cancers
Hiroaki Kiyokawa
exaly   +2 more sources

The Role of Epstein-Barr Virus in Modulating Key Tumor Suppressor Genes in Associated Malignancies: Epigenetics, Transcriptional, and Post-Translational Modifications

Biomolecules, 2022
Epstein-Barr virus (EBV) is ubiquitous and carried by approximately 90% of the world’s adult population. Several mechanisms and pathways have been proposed as to how EBV facilitates the pathogenesis and progression of malignancies, such as Hodgkin’s ...
Adelaide Ohui Fierti, Michael Bright Yakass, Ernest Adjei Okertchiri, Samuel Mawuli Adadey, Osbourne Quaye   +4 more
doaj   +1 more source

From Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immune Response to Cancer Onset via Molecular Mimicry and Cross-Reactivity

Global Medical Genetics, 2021
Background and Objectives Whether exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may predispose to the risk of cancer in individuals with no prior cancers is a crucial question that remains unclear.
Darja Kanduc
doaj   +1 more source

Retinoblastoma Protein Paralogs and Tumor Suppression

Frontiers in Genetics, 2022
The retinoblastoma susceptibility gene (RB1) is the first tumor suppressor gene discovered and a prototype for understanding regulatory networks that function in opposition to oncogenic stimuli.
Mauricio Flores, David W. Goodrich
doaj   +1 more source

Targeted protein degradation as a tumor suppressor [PDF]

Cell Cycle, 2014
Targeted protein degradation by the ubiquitin-proteasome system (UPS) has an essential role in carcinogenesis and cancer cell survival. Thus, the search for proteasome inhibitors is of great interest as a potential anticancer therapy.1 Recent studies by the Ferbeyre group suggest that certain UPS-targeted proteins play a role not just in carcinogenesis,
Arat, Nezahat Ozlem, Harrington, Lea
openaire   +2 more sources