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Tumor suppressor p53 cross-talks with TRIM family proteins
Genes and Diseases, 2021 p53 is a key tumor suppressor. As a transcription factor, p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor ...
Juan Liu +4 more
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VAV Proteins as Double Agents in Cancer: Oncogenes with Tumor Suppressor Roles
Biology, 2021 Guanosine nucleotide exchange factors (GEFs) are responsible for catalyzing the transition of small GTPases from the inactive (GDP-bound) to the active (GTP-bound) states. RHO GEFs, including VAV proteins, play essential signaling roles in a wide variety
Myriam Cuadrado, Javier Robles-Valero
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White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy [PDF]
Cancers, 2022 Peter Habenberger +2 more
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The Rosetta Stone Hypothesis-Based Interaction of the Tumor Suppressor Proteins Nit1 and Fhit [PDF]
Cells, 2023 Sebastian Y Müller +2 more
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A Perspective on Therapeutic Targeting Against Ubiquitin Ligases to Stabilize Tumor Suppressor Proteins [PDF]
CancersHiroaki Kiyokawa
exaly +2 more sources
Biomolecules, 2022 Epstein-Barr virus (EBV) is ubiquitous and carried by approximately 90% of the world’s adult population. Several mechanisms and pathways have been proposed as to how EBV facilitates the pathogenesis and progression of malignancies, such as Hodgkin’s ...
Adelaide Ohui Fierti +4 more
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Global Medical Genetics, 2021 Background and Objectives Whether exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may predispose to the risk of cancer in individuals with no prior cancers is a crucial question that remains unclear.
Darja Kanduc
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Retinoblastoma Protein Paralogs and Tumor Suppression
Frontiers in Genetics, 2022 The retinoblastoma susceptibility gene (RB1) is the first tumor suppressor gene discovered and a prototype for understanding regulatory networks that function in opposition to oncogenic stimuli.
Mauricio Flores, David W. Goodrich
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Targeted protein degradation as a tumor suppressor [PDF]
Cell Cycle, 2014 Targeted protein degradation by the ubiquitin-proteasome system (UPS) has an essential role in carcinogenesis and cancer cell survival. Thus, the search for proteasome inhibitors is of great interest as a potential anticancer therapy.1 Recent studies by the Ferbeyre group suggest that certain UPS-targeted proteins play a role not just in carcinogenesis,
Arat, Nezahat Ozlem, Harrington, Lea
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Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein [PDF]
Cancer Cell, 2009 The retinoblastoma protein (pRB) tumor suppressor blocks cell proliferation by repressing the E2F transcription factors. This inhibition is relieved through mitogen-induced phosphorylation of pRB, triggering E2F release and activation of cell-cycle genes. E2F1 can also activate proapoptotic genes in response to genotoxic or oncogenic stress.
IANARI, Alessandra +8 more
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