Results 1 to 10 of about 304,620 (215)
White Paper: Mimetics of Class 2 Tumor Suppressor Proteins as Novel Drug Candidates for Personalized Cancer Therapy [PDF]
Cancers, 2022 Edgar Dahl +2 more
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Targeted protein degradation as a tumor suppressor [PDF]
Cell Cycle, 2014 Targeted protein degradation by the ubiquitin-proteasome system (UPS) has an essential role in carcinogenesis and cancer cell survival. Thus, the search for proteasome inhibitors is of great interest as a potential anticancer therapy.1 Recent studies by the Ferbeyre group suggest that certain UPS-targeted proteins play a role not just in carcinogenesis,
Arat, Nezahat Ozlem, Harrington, Lea
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Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein [PDF]
Cancer Cell, 2009 The retinoblastoma protein (pRB) tumor suppressor blocks cell proliferation by repressing the E2F transcription factors. This inhibition is relieved through mitogen-induced phosphorylation of pRB, triggering E2F release and activation of cell-cycle genes. E2F1 can also activate proapoptotic genes in response to genotoxic or oncogenic stress.
IANARI, Alessandra +8 more
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Protein kinase C as a tumor suppressor [PDF]
Seminars in Cancer Biology, 2018 Protein kinase C (PKC) has historically been considered an oncoprotein. This stems in large part from the discovery in the early 1980s that PKC is directly activated by tumor-promoting phorbol esters. Yet three decades of clinical trials using PKC inhibitors in cancer therapies not only failed, but in some cases worsened patient outcome.
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Hypothetical protein predicted to be tumor suppressor: a protein functional analysis [PDF]
Genomics & Informatics, 2021 Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and function of the biologically important hypothetical ...
Md. Abdul Kader +5 more
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The tumor suppressor protein p150Sal2 in carcinogenesis
Tumor Biology, 2015 The transcription factor p150(Sal2), the product of the SALL2 gene, was first identified as a binding target of the oncogenic mouse polyomavirus T antigen. However, mouse polyomavirus is not the only oncogenic virus that targets p150(Sal2); the human papillomavirus E6 protein also targets this cellular protein in order to overcome p150(Sal2)-mediated ...
Chang Kyoo, Sung, Hyungshin, Yim
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A neuronal function of the tumor suppressor protein merlin [PDF]
Acta Neuropathologica Communications, 2014 Mutagenic loss of the NF2 tumor suppressor gene encoded protein merlin is known to provoke the hereditary neoplasia syndrome, Neurofibromatosis type 2 (NF2). In addition to glial cell-derived tumors in the PNS and CNS, disease-related lesions also affect the skin and the eyes.
Schulz, Alexander +2 more
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Interaction of metallothionein with tumor suppressor p53 protein [PDF]
FEBS Letters, 2006 Previous reports have shown that metallothionein (MT) may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between MT and p53 in cells. The results demonstrate an interaction between MT and p53 can occur in vitro.
Ostrakhovitch, Elena A. +3 more
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The tumor suppressor protein p53 and the ferroptosis network [PDF]
Free Radical Biology and Medicine, 2019 Ferroptosis is a form of lipid peroxidation-induced cell death that can be regulated in many ways, from altering the activity of antioxidant enzymes to the level of transcription factors. The p53 tumor suppressor is 'the guardian of the genome' that participates in the control of cell survival and division under various stresses.
Kang, Rui, Kroemer, Guido, Tang, Daolin
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Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein [PDF]
Science, 1995 Germline mutations in the von Hippel-Lindau tumor suppressor gene ( VHL ) predispose individuals to a variety of tumors, including renal carcinoma, hemangioblastoma of the central nervous system, and pheochromocytoma.
Duan, D. +9 more
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