Results 11 to 20 of about 302,791 (267)
Targeted protein degradation as a tumor suppressor [PDF]
Cell Cycle, 2014 Targeted protein degradation by the ubiquitin-proteasome system (UPS) has an essential role in carcinogenesis and cancer cell survival. Thus, the search for proteasome inhibitors is of great interest as a potential anticancer therapy.1 Recent studies by the Ferbeyre group suggest that certain UPS-targeted proteins play a role not just in carcinogenesis,
Arat, Nezahat Ozlem, Harrington, Lea
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S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study
Translational Oncology, 2020 Novel coronavirus disease 2019 (COVID-19) is the biggest threat to human being globally. The first case was identified in a patient with flu symptoms along with severe acute respiratory syndrome in Wuhan, China in December 2019 and now it has spread in ...
Nishant Singh, Anuradha Bharara Singh
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Expression of p53, p16 and Ki67 proteins in ductal adenocarcinoma of the pancreatic head and their relation with survival and cell differentiation [PDF]
Einstein (São Paulo), 2010 Objective: To determine the expression of p53, p16 and Ki-67 and its relevance in survival and cell differentiation. Methods: Fifteen duodenopancreatectomized patients were included. Immunohistochemical expression of p53, p16 and Ki-67 was determined in
Mário Benjamin Goitia-Durán +5 more
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PML surfs into HIPPO tumor suppressor pathway
Frontiers in Oncology, 2013 Growth arrest, inhibition of cell proliferation, apoptosis, senescence and differentiation are the most characterized effects of a given tumor suppressor response.
Sabrina eStrano +5 more
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Mutant p53 : One, No One and One Hundred Thousand
Frontiers in Oncology, 2015 Encoded by the mutated variants of the TP53 tumor suppressor gene, mutant p53 proteins are getting an increased experimental support as active oncoproteins promoting tumor growth and metastasis.
Dawid eWalerych +4 more
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H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers
eLife, 2018 Expression of histone H3.3K27M mutant proteins in human diffuse intrinsic pontine glioma (DIPG) results in a global reduction of tri-methylation of H3K27 (H3K27me3), and paradoxically, H3K27me3 peaks remain at hundreds of genomic loci, a dichotomous ...
Dong Fang +7 more
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Molecular Oncology, 2011 Aneuploidy, often preceded by tetraploidy, is one of the hallmarks of solid tumors. Indeed, both aneuploidy and tetraploidy are oncogenic occurrences that are sufficient to drive neoplastic transformation and cancer progression.
Yael Aylon, Moshe Oren
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Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein [PDF]
Cancer Cell, 2009 The retinoblastoma protein (pRB) tumor suppressor blocks cell proliferation by repressing the E2F transcription factors. This inhibition is relieved through mitogen-induced phosphorylation of pRB, triggering E2F release and activation of cell-cycle genes. E2F1 can also activate proapoptotic genes in response to genotoxic or oncogenic stress.
IANARI, Alessandra +8 more
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Cells, 2022 Tumor suppressor WWOX inhibits cancer growth and retards Alzheimer’s disease (AD) progression. Supporting evidence shows that the more strongly WWOX binds intracellular protein partners, the weaker is cancer cell growth in vivo.
Tsung-Yun Liu +7 more
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Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation [PDF]
Cancers, 2020 Mutations that result in the loss of function of pRB were first identified in retinoblastoma and since then have been associated with the propagation of various forms of cancer. pRB is best known for its key role as a transcriptional regulator during cell cycle exit.
Frederick Guzman +5 more
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