Results 11 to 20 of about 308,123 (261)
Selective inhibitors of nuclear export for the treatment of non-Hodgkin’s lymphomas
Haematologica, 2013 The nuclear export protein chromosome maintenance region 1, found to be elevated in non-Hodgkin’s lymphomas, controls localization of critical tumor suppressor proteins.
Asfar S. Azmi +6 more
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Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors
Molecular Cancer, 2007 The question of whether p73 is a tumor suppressor gene, is not yet answered with full confidence. The lack of spontaneous tumor formation in p73 null mice and infrequent p73 mutations seen in a variety of cancers analyzed would straightaway negate its ...
Boominathan Lakshmanane
doaj +1 more source
Dental Research Journal, 2015 Background: The role of retinoblastoma (Rb) protein in cell cycle regulation prompted us to take up this study with the aim of assessing its role in the progression of oral cancer and to correlate with various clinicopathological parameters, including ...
Sunila Thomas +2 more
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Molecular Cancer, 2019 Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg ...
Ju-Ha Kim +5 more
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Neurobiology of Disease, 2001 The neurofibromatosis 2 (NF2) tumor suppressor belongs to the Protein 4.1 family of molecules that link the actin cytoskeleton to cell surface glycoproteins.
David H. Gutmann +3 more
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PML surfs into HIPPO tumor suppressor pathway
Frontiers in Oncology, 2013 Growth arrest, inhibition of cell proliferation, apoptosis, senescence and differentiation are the most characterized effects of a given tumor suppressor response.
Sabrina eStrano +5 more
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Protein kinase C as a tumor suppressor [PDF]
Seminars in Cancer Biology, 2018 Protein kinase C (PKC) has historically been considered an oncoprotein. This stems in large part from the discovery in the early 1980s that PKC is directly activated by tumor-promoting phorbol esters. Yet three decades of clinical trials using PKC inhibitors in cancer therapies not only failed, but in some cases worsened patient outcome.
openaire +4 more sources
Expression of p53, p16 and Ki67 proteins in ductal adenocarcinoma of the pancreatic head and their relation with survival and cell differentiation [PDF]
Einstein (São Paulo), 2010 Objective: To determine the expression of p53, p16 and Ki-67 and its relevance in survival and cell differentiation. Methods: Fifteen duodenopancreatectomized patients were included. Immunohistochemical expression of p53, p16 and Ki-67 was determined in
Mário Benjamin Goitia-Durán +5 more
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S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study
Translational Oncology, 2020 Novel coronavirus disease 2019 (COVID-19) is the biggest threat to human being globally. The first case was identified in a patient with flu symptoms along with severe acute respiratory syndrome in Wuhan, China in December 2019 and now it has spread in ...
Nishant Singh, Anuradha Bharara Singh
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Mutant p53 : One, No One and One Hundred Thousand
Frontiers in Oncology, 2015 Encoded by the mutated variants of the TP53 tumor suppressor gene, mutant p53 proteins are getting an increased experimental support as active oncoproteins promoting tumor growth and metastasis.
Dawid eWalerych +4 more
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