The protein kinase DYRK1B is a p53 target gene and functions as a negative feedback regulator of the transcription factor RFX7 [PDF]
Cell Death and DiseaseThe tumor suppressor protein p53 orchestrates cellular responses to stress by regulating the transcription of target genes involved in processes such as cell cycle control, DNA damage repair and apoptosis.
Gerrit Wilms +8 more
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Tumor suppressor protein p53 governs human trophoblast lineage development
Cell ReportsSummary: Tumor suppressor protein p53 (encoded by Trp53 in mice and TP53 in humans) has important functions in normal development. Dysregulated Trp53 expression in mice causes multiple embryonic developmental defects or even implantation failure. However,
Yunying Huang +22 more
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Small Molecule Inhibitors of MDM2-p53 and MDMX-p53 Interactions as New Cancer Therapeutics [PDF]
BioDiscovery, 2013 Inactivation of the function of tumor suppressor p53 is common in human cancers. In approximately half of human cancers, the tumor suppressor function of p53 is inactivated by deletion or mutation of TP53, the gene encoding p53 protein.
Yujun Zhao +2 more
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Cross-regulation of protein stability by p53 and nuclear receptor SHP. [PDF]
PLoS ONE, 2012 We report here a novel interplay between tumor suppressor p53 and nuclear receptor SHP that controls p53 and SHP stability. Overexpression of p53 causes rapid SHP protein degradation, which does not require the presence of Mdm2 and is mediated by the ...
Zhihong Yang +3 more
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Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer. [PDF]
PLoS ONE, 2015 Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC).
Kathleen Saavedra +10 more
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Zmat3 splices together p53-dependent tumor suppression
Molecular & Cellular Oncology, 2021 The tumor protein p53 (TP53, best known as p53) transcription factor is a critical tumor suppressor, but those p53-inducible genes most important for tumor suppression have remained unclear. Using unbiased RNA interference and CRISPR (Clustered Regularly
Kathryn T. Bieging-Rolett +1 more
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Nature Communications, 2021 Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell ...
L. Palanikumar +20 more
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Recent Synthetic Approaches towards Small Molecule Reactivators of p53
Biomolecules, 2020 The tumor suppressor protein p53 is often called “the genome guardian” and controls the cell cycle and the integrity of DNA, as well as other important cellular functions.
Jerson L. Silva +8 more
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P53 orchestrates a complex symphony of cellular processes during oncosuppression
Molecular & Cellular Oncology, 2021 We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse ...
Liz J. Valente, Laura D. Attardi
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Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
Nature Communications, 2021 The structure of human tumor suppressor p53 in complex with the antiapoptotic protein BCL-xL reveals the basis of the p53–BCL-xL interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.
Hudie Wei +13 more
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