Results 1 to 10 of about 148,781 (262)
The tumor suppressor protein p53 and the ferroptosis network. [PDF]
Free Radic Biol Med, 2019 Ferroptosis is a form of lipid peroxidation-induced cell death that can be regulated in many ways, from altering the activity of antioxidant enzymes to the level of transcription factors. The p53 tumor suppressor is 'the guardian of the genome' that participates in the control of cell survival and division under various stresses.
Kang R, Kroemer G, Tang D.
europepmc +5 more sources
Prognostic significance of tumor suppressor protein p53 in prostate cancer. [PDF]
Tunis MedBackround: The p53 gene mutation is one of the most common genetic alterations in many cancers. In prostate cancer (PCa), it has been associated with a poor prognosis, tumor progression and aggressiveness. P53 mutation induces an abnormal protein expression in related tissues. Aim: This study aimed to assess p53 expression using immunohistochemistry in
Ben Rejeb S +4 more
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Small Molecule Inhibitors of MDM2-p53 and MDMX-p53 Interactions as New Cancer Therapeutics [PDF]
BioDiscovery, 2013 Inactivation of the function of tumor suppressor p53 is common in human cancers. In approximately half of human cancers, the tumor suppressor function of p53 is inactivated by deletion or mutation of TP53, the gene encoding p53 protein.
Yujun Zhao +2 more
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Cross-regulation of protein stability by p53 and nuclear receptor SHP. [PDF]
PLoS ONE, 2012 We report here a novel interplay between tumor suppressor p53 and nuclear receptor SHP that controls p53 and SHP stability. Overexpression of p53 causes rapid SHP protein degradation, which does not require the presence of Mdm2 and is mediated by the ...
Zhihong Yang +3 more
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Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer. [PDF]
PLoS ONE, 2015 Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC).
Kathleen Saavedra +10 more
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Zmat3 splices together p53-dependent tumor suppression
Molecular & Cellular Oncology, 2021 The tumor protein p53 (TP53, best known as p53) transcription factor is a critical tumor suppressor, but those p53-inducible genes most important for tumor suppression have remained unclear. Using unbiased RNA interference and CRISPR (Clustered Regularly
Kathryn T. Bieging-Rolett +1 more
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Nature Communications, 2021 Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell ...
L. Palanikumar +20 more
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Interaction of metallothionein with tumor suppressor p53 protein [PDF]
FEBS Letters, 2006 Previous reports have shown that metallothionein (MT) may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between MT and p53 in cells. The results demonstrate an interaction between MT and p53 can occur in vitro.
Ostrakhovitch, Elena A. +3 more
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Recent Synthetic Approaches towards Small Molecule Reactivators of p53
Biomolecules, 2020 The tumor suppressor protein p53 is often called “the genome guardian” and controls the cell cycle and the integrity of DNA, as well as other important cellular functions.
Jerson L. Silva +8 more
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Targeting p53 pathways: mechanisms, structures and advances in therapy
Signal Transduction and Targeted Therapy, 2023 The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles ...
Haolan Wang +3 more
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