TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background [PDF]
Frontiers in Oncology, 2019 The p53 gene family network plays a pivotal role in the control of many biological processes and therefore the right balance between the pro-apoptotic and pro-survival isoforms is key to maintain cellular homeostasis.
Mariano Francesco Caratozzolo +10 more
doaj +4 more sources
The protein kinase DYRK1B is a p53 target gene and functions as a negative feedback regulator of the transcription factor RFX7 [PDF]
Cell Death and DiseaseThe tumor suppressor protein p53 orchestrates cellular responses to stress by regulating the transcription of target genes involved in processes such as cell cycle control, DNA damage repair and apoptosis.
Gerrit Wilms +8 more
doaj +2 more sources
Protein adduction causes non-mutational inhibition of p53 tumor suppressor
Cell Reports, 2023 Summary: p53 is a key tumor suppressor that is frequently mutated in human tumors. In this study, we investigated how p53 is regulated in precancerous lesions prior to mutations in the p53 gene.
Ravindran Caspa Gokulan +10 more
doaj +3 more sources
p53: from understanding its structure to advances in therapeutic targeting [PDF]
Signal Transduction and Targeted TherapyThe tumor suppressor gene TP53 is the most frequently mutated gene in human cancers and has been a popular area of research in the field of oncology.
Wenhua Wang +6 more
doaj +2 more sources
Clinicopathological and targeted exome gene features of a patient with metastatic acinic cell carcinoma of the parotid gland harboring an ARID2 nonsense mutation and CDKN2A/B deletion [PDF]
, 2015 We describe the presentation, treatment, clinical outcome, and targeted genome analysis of a metastatic salivary acinic cell carcinoma (AciCC). A 71-year-old male presented with a 3 cm right tail of a parotid lesion, first detected as a nodule by the ...
Momand, Jamil +4 more
core +19 more sources
The tumor suppressor protein p53 and the ferroptosis network. [PDF]
Free Radic Biol Med, 2019 Ferroptosis is a form of lipid peroxidation-induced cell death that can be regulated in many ways, from altering the activity of antioxidant enzymes to the level of transcription factors. The p53 tumor suppressor is 'the guardian of the genome' that participates in the control of cell survival and division under various stresses.
Kang R, Kroemer G, Tang D.
europepmc +5 more sources
Small Molecule Inhibitors of MDM2-p53 and MDMX-p53 Interactions as New Cancer Therapeutics [PDF]
BioDiscovery, 2013 Inactivation of the function of tumor suppressor p53 is common in human cancers. In approximately half of human cancers, the tumor suppressor function of p53 is inactivated by deletion or mutation of TP53, the gene encoding p53 protein.
Yujun Zhao +2 more
doaj +3 more sources
Cross-regulation of protein stability by p53 and nuclear receptor SHP. [PDF]
PLoS ONE, 2012 We report here a novel interplay between tumor suppressor p53 and nuclear receptor SHP that controls p53 and SHP stability. Overexpression of p53 causes rapid SHP protein degradation, which does not require the presence of Mdm2 and is mediated by the ...
Zhihong Yang +3 more
doaj +1 more source
Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer. [PDF]
PLoS ONE, 2015 Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC).
Kathleen Saavedra +10 more
doaj +1 more source
AKT regulates NPM dependent ARF localization and p53mut stability in tumors [PDF]
, 2014 Nucleophosmin (NPM) is known to regulate ARF subcellular localization and MDM2 activity in response to oncogenic stress, though the precise mechanism has remained elusive.
Abraham, Aswin G. +12 more
core +8 more sources