P53 orchestrates a complex symphony of cellular processes during oncosuppression
Molecular & Cellular Oncology, 2021 We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse ...
Liz J. Valente, Laura D. Attardi
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Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
Nature Communications, 2021 The structure of human tumor suppressor p53 in complex with the antiapoptotic protein BCL-xL reveals the basis of the p53–BCL-xL interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.
Hudie Wei +13 more
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TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background
Frontiers in Oncology, 2019 The p53 gene family network plays a pivotal role in the control of many biological processes and therefore the right balance between the pro-apoptotic and pro-survival isoforms is key to maintain cellular homeostasis.
Mariano Francesco Caratozzolo +10 more
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The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect. [PDF]
PLoS ONE, 2013 p53, one of the most well studied tumor suppressor factor, is responsible to a variety of damage owing to the induction of apoptosis and cell cycle arrest in the tumor cells.
Peiyuan Jia +6 more
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HSP70 Binding Sites in the Tumor Suppressor Protein p53 [PDF]
Journal of Biological Chemistry, 1997 Mutations within conserved regions of the tumor suppressor protein, p53, result in oncogenic forms of the protein with altered tertiary structures. In most cases, the mutant p53 proteins are selectively recognized and bound by members of the HSP70 family of molecular chaperones, but the binding site(s) in p53 for these chaperones have not been clearly ...
A M, Fourie +6 more
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p53 regulation by TRP2 is not pervasive in melanoma. [PDF]
PLoS ONE, 2014 p53 is a central tumor suppressor protein and its inhibition is believed to be a prerequisite for cancer development. In approximately 50% of all malignancies this is achieved by inactivating mutations in the p53 gene. However, in several cancer entities,
Roland Houben +9 more
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A novel protein with strong homology to the tumor suppressor p53 [PDF]
Oncogene, 1997 The p53 tumor suppressor orchestrates a number of important genes involved in cell-cycle control and apoptosis. Mice deficient for p53 show a high incidence of cancer but are developmentally normal suggesting that compensatory mechanisms exist in embryogenesis and differentiation.
H, Schmale, C, Bamberger
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Immunohistochemical Determination of p53 Protein Overexpression for Predicting p53 Gene Mutations in Hepatocellular Carcinoma: A Meta-Analysis. [PDF]
PLoS ONE, 2016 Whether increased expression of the tumor suppressor protein p53 indicates a p53 gene mutation in hepatocellular carcinoma (HCC) remains unclear.
Jiangbo Liu +5 more
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On the involvement of calpains in the degradation of the tumor suppressor protein p53 [PDF]
FEBS Letters, 1997 A crude fraction that contains ubiquitin–protein ligases contains also a proteolytic activity of ∼100 kDa that cleaves p53 to several fragments. The protease does not require ATP and is inhibited in the crude extract by an endogenous ∼250 kDa inhibitor.
Gonen, Hedva +4 more
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Clinical Significance of Mutant P53 Protein Expression in Lung Adenocarcinoma
Chinese Journal of Lung Cancer, 2015 Background and objective P53 is a tumor protein that acts as a tumor suppressor. The mutation of P53 may cause loss of tumor suppressor functions and gain of functions favoring cellular proliferation and apoptosis inhibition. The clinical implications of
Chun’an BIAN +5 more
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