Results 11 to 20 of about 154,391 (307)

The tumor suppressor protein p53 and the ferroptosis network. [PDF]

Free Radic Biol Med, 2019
Ferroptosis is a form of lipid peroxidation-induced cell death that can be regulated in many ways, from altering the activity of antioxidant enzymes to the level of transcription factors. The p53 tumor suppressor is 'the guardian of the genome' that participates in the control of cell survival and division under various stresses.
Kang R, Kroemer G, Tang D.
europepmc   +5 more sources

Interaction of metallothionein with tumor suppressor p53 protein [PDF]

FEBS Letters, 2006
Previous reports have shown that metallothionein (MT) may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between MT and p53 in cells. The results demonstrate an interaction between MT and p53 can occur in vitro.
Ostrakhovitch, Elena A., Olsson, Per-Erik, Jiang, Sean, Cherian, M. George   +3 more
openaire   +2 more sources

Targeting p53 pathways: mechanisms, structures and advances in therapy

Signal Transduction and Targeted Therapy, 2023
The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles ...
Haolan Wang, Ming Guo, Hudie Wei, Yongheng Chen   +3 more
doaj   +1 more source

TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background

Frontiers in Oncology, 2019
The p53 gene family network plays a pivotal role in the control of many biological processes and therefore the right balance between the pro-apoptotic and pro-survival isoforms is key to maintain cellular homeostasis.
Mariano Francesco Caratozzolo, Flaviana Marzano, Daniela Isabel Abbrescia, Francesca Mastropasqua, Vittoria Petruzzella, Viola Calabrò, Graziano Pesole, Graziano Pesole, Elisabetta Sbisà, Luisa Guerrini, Apollonia Tullo   +10 more
doaj   +1 more source

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]

, 1993
The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Caselmann, Wolfgang H., Gerbes, Alexander L.   +1 more
core   +1 more source

Prognostic significance of tumor suppressor protein p53 in prostate cancer. [PDF]

Tunis Med
Backround: The p53 gene mutation is one of the most common genetic alterations in many cancers. In prostate cancer (PCa), it has been associated with a poor prognosis, tumor progression and aggressiveness. P53 mutation induces an abnormal protein expression in related tissues. Aim: This study aimed to assess p53 expression using immunohistochemistry in
Ben Rejeb S, Kouki N, Elfekih S, Cherif I, Khouni H.   +4 more
europepmc   +3 more sources

p53 Expression in Colorectal Carcinoma in Relation to Histopathological Features in Ugandan Patients. [PDF]

, 2008
It has been shown that colorectal carcinoma is increasing in incidence in African countries. This could be due to change in life style. Molecular pathogenesis of colorectal cancer commonly involves mutation in p53 gene which leads to expression of p53 ...
Rambau, PF, Rambau, Peter F., Rambau, Peter F, Odida, Michael, Wabinga, Henry, Odida, M, Wabinga, H   +6 more
core   +1 more source

The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect. [PDF]

PLoS ONE, 2013
p53, one of the most well studied tumor suppressor factor, is responsible to a variety of damage owing to the induction of apoptosis and cell cycle arrest in the tumor cells.
Peiyuan Jia, Yu Zhao, Shaoping Wu, Junhua Wu, Shan Gao, Ying Tong, Yuxia Wang   +6 more
doaj   +1 more source

HSP70 Binding Sites in the Tumor Suppressor Protein p53 [PDF]

Journal of Biological Chemistry, 1997
Mutations within conserved regions of the tumor suppressor protein, p53, result in oncogenic forms of the protein with altered tertiary structures. In most cases, the mutant p53 proteins are selectively recognized and bound by members of the HSP70 family of molecular chaperones, but the binding site(s) in p53 for these chaperones have not been clearly ...
A M, Fourie, T R, Hupp, D P, Lane, B C, Sang, M S, Barbosa, J F, Sambrook, M J, Gething   +6 more
openaire   +2 more sources

Role of p53 serine 46 in p53 target gene regulation [PDF]

, 2011
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of different response pathways. The molecular mechanisms that discriminate between the distinct p53-responses have remained largely elusive.
Bianca Gilbert, Simon J. van Heeringen, Smeenk, L., Hendrik G Stunnenberg, Smeenk, Leonie, Eva Janssen-Megens, Lohrum, Marion, Koeppel, M., Heeringen, S.J. van, Hendrik G. Stunnenberg, Gilbert, Bianca, Lohrum, M., Stunnenberg, H.G., Stunnenberg, Hendrik G., Max Koeppel, Leonie Smeenk, Janssen-Megens, Eva, Heeringen, Simon J. van, Janssen-Megens, E.M., Marion Lohrum, Gilbert, B., Köppel, Max, Simon J van Heeringen   +22 more
core   +1 more source