Results 11 to 20 of about 4,575,740 (255)

Characterisation of the p53-Mediated Cellular Responses Evoked in Primary Mouse Cells Following Exposure to Ultraviolet Radiation [PDF]

, 2013
Exposure to ultraviolet (UV) light can cause significant damage to mammalian cells and, although the spectrum of damage produced varies with the wavelength of UV, all parts of the UV spectrum are recognised as being detrimental to human health ...
McFeat, Gillian, McMillan, Trevor, Allinson, Sarah   +2 more
core   +5 more sources

TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background

Frontiers in Oncology, 2019
The p53 gene family network plays a pivotal role in the control of many biological processes and therefore the right balance between the pro-apoptotic and pro-survival isoforms is key to maintain cellular homeostasis.
Mariano Francesco Caratozzolo, Flaviana Marzano, Daniela Isabel Abbrescia, Francesca Mastropasqua, Vittoria Petruzzella, Viola Calabrò, Graziano Pesole, Graziano Pesole, Elisabetta Sbisà, Luisa Guerrini, Apollonia Tullo   +10 more
doaj   +1 more source

Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]

, 1993
The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Caselmann, Wolfgang H., Gerbes, Alexander L.   +1 more
core   +1 more source

p53 Expression in Colorectal Carcinoma in Relation to Histopathological Features in Ugandan Patients. [PDF]

, 2008
It has been shown that colorectal carcinoma is increasing in incidence in African countries. This could be due to change in life style. Molecular pathogenesis of colorectal cancer commonly involves mutation in p53 gene which leads to expression of p53 ...
Rambau, PF, Rambau, Peter F., Rambau, Peter F, Odida, Michael, Wabinga, Henry, Odida, M, Wabinga, H   +6 more
core   +1 more source

The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect. [PDF]

PLoS ONE, 2013
p53, one of the most well studied tumor suppressor factor, is responsible to a variety of damage owing to the induction of apoptosis and cell cycle arrest in the tumor cells.
Peiyuan Jia, Yu Zhao, Shaoping Wu, Junhua Wu, Shan Gao, Ying Tong, Yuxia Wang   +6 more
doaj   +1 more source

Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]

, 2012
The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Daniel P. Teufel, Fiona M. Townsley (123705), Stefan M. V. Freund (123709), Stefan M V Freund, Teufel, Daniel P., Stefan M. V. Freund, Daniel P. Teufel (123707), Tobias Br, Tobias Brandt (123703), Townsley, Fiona M., Dmitry B Veprintsev, Veprintsev, Dmitry B., Fiona M. Townsley, Tobias Brandt, Dmitry B. Veprintsev (109095), Freund, Stefan M. V., Daniel P Teufel, Fiona M Townsley, Dmitry B. Veprintsev, Brandt, Tobias   +19 more
core   +2 more sources

Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]

, 2000
This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia, Lane, David P., T. Hay, Ronald, Hay, Ronald Thomas, Rodriguez, Manuel S, Desterro, Joana M P   +6 more
core   +1 more source

Role of p53 serine 46 in p53 target gene regulation [PDF]

, 2011
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of different response pathways. The molecular mechanisms that discriminate between the distinct p53-responses have remained largely elusive.
Bianca Gilbert, Simon J. van Heeringen, Smeenk, L., Hendrik G Stunnenberg, Smeenk, Leonie, Eva Janssen-Megens, Lohrum, Marion, Koeppel, M., Heeringen, S.J. van, Hendrik G. Stunnenberg, Gilbert, Bianca, Lohrum, M., Stunnenberg, H.G., Stunnenberg, Hendrik G., Max Koeppel, Leonie Smeenk, Janssen-Megens, Eva, Heeringen, Simon J. van, Janssen-Megens, E.M., Marion Lohrum, Gilbert, B., Köppel, Max, Simon J van Heeringen   +22 more
core   +3 more sources

p53 regulation by TRP2 is not pervasive in melanoma. [PDF]

PLoS ONE, 2014
p53 is a central tumor suppressor protein and its inhibition is believed to be a prerequisite for cancer development. In approximately 50% of all malignancies this is achieved by inactivating mutations in the p53 gene. However, in several cancer entities,
Roland Houben, Corinna P Schmid, Melissa Maier, Marion Wobser, Stephanie Motschenbacher, Jürgen C Becker, Claudia S Vetter-Kauczok, Gerhard Weyandt, Sonja Hesbacher, Sebastian Haferkamp   +9 more
doaj   +1 more source

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane [PDF]

, 2002
p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 ...
Bourdon, J.-C.; id_orcid, K.N. Fernandes, P.L. Robertson, Robertson, P. L., J.-C. Bourdon, Fernandes, K. N., Lane, D. P., J. Renzing, Renzing, J., D.P. Lane   +9 more
core   +1 more source