Prognostic significance of tumor suppressor protein p53 in prostate cancer. [PDF]
Tunis MedBackround: The p53 gene mutation is one of the most common genetic alterations in many cancers. In prostate cancer (PCa), it has been associated with a poor prognosis, tumor progression and aggressiveness. P53 mutation induces an abnormal protein expression in related tissues. Aim: This study aimed to assess p53 expression using immunohistochemistry in
Ben Rejeb S +4 more
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Prediction Of Cancer Possibility By Pattern Recognition And Statistical Study Of Expression Of Gene Level Of Cancer Cells [PDF]
, 2011 The activity of the p53 tumor-suppressor protein has a key role in controlling both cancer and aging: under activity encourages the growth of cancer, and over activity can accelerate the aging process.
Devang Odedra, Medhavi Mallick
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Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]
, 1993 The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Alexander L. Gerbes +40 more
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Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]
, 2014 Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
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The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect. [PDF]
PLoS ONE, 2013 p53, one of the most well studied tumor suppressor factor, is responsible to a variety of damage owing to the induction of apoptosis and cell cycle arrest in the tumor cells.
Peiyuan Jia +6 more
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miRNAs link metabolic reprogramming to oncogenesis [PDF]
, 2013 The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M +2 more
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Tumor suppressor protein p53 binds preferentially to supercoiled DNA [PDF]
Oncogene, 1997 Wild type human tumor suppressor protein p53 (expressed in insect cells) binds strongly to negatively supercoiled (sc) plasmid DNA at a native superhelix density, as evidenced by electrophoretic retardation of scDNA in agarose gels and imaging by scanning force microscopy (SFM).
Palecek, E. +7 more
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CONTRASTING EFFECTS OF AN MDM2 FUNCTIONAL POLYMORPHISM ON TUMOR PHENOTYPES [PDF]
, 2017 Cancer predisposition by the cooperation of genetic variants, such as single nucleotide polymorphisms (SNPs), may be of much greater significance to public health than previously appreciated.
Ortiz, Guadalupe J, IV
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Cytoplasmic gain-of-function mutant p53 contributes to inflammation-associated cancer [PDF]
, 2015 Inflammation and mutation of the tumor suppressor p53 are two apparently unrelated conditions that are strongly associated with cancer initiation and progression. We recently reported that gain-of-function mutant p53 modifies the response of cancer cells
Bellazzo, Arianna +2 more
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HSP70 Binding Sites in the Tumor Suppressor Protein p53 [PDF]
Journal of Biological Chemistry, 1997 Mutations within conserved regions of the tumor suppressor protein, p53, result in oncogenic forms of the protein with altered tertiary structures. In most cases, the mutant p53 proteins are selectively recognized and bound by members of the HSP70 family of molecular chaperones, but the binding site(s) in p53 for these chaperones have not been clearly ...
A M, Fourie +6 more
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