Results 21 to 30 of about 148,781 (262)

Deregulation of p53 and RB Transcriptional Control Leads to Overexpression of DNA Methyltransferases in Lung Cancer

Journal of Cancer Research and Practice, 2014
Background: Overexpression of DNA 5’-cytosine-methyltransferases (DNMTs), which silence genes including tumor suppressor genes, is involved in many cancers. However, the mechanism of DNMT overexpression remains mostly unclear.
Yen-An Tang, Yo-Ting Tsai, Ruo-Kai Lin, Han-Shui Hsu, Chih-Yi Chen, Yi-Ching Wang   +5 more
doaj   +1 more source

The Competition of Yin and Yang: Exploring the Role of Wild-Type and Mutant p53 in Tumor Progression

Biomedicines, 2023
The protein p53 is a well-known tumor suppressor that plays a crucial role in preventing cancer development [...]
Bi-He Cai, Yu-Te Sung, Chia-Chi Chen, Jei-Fu Shaw, I-Lun Hsin   +4 more
doaj   +1 more source

Long noncoding RNAs: p53's secret weapon in the fight against cancer?

PLoS Biology, 2019
p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor effects of p53.
Emily Dangelmaier, Sarah B Lazar, Ashish Lal   +2 more
doaj   +1 more source

The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes

Nature Communications, 2021
The p53 tumor suppressor is also a regulator of metabolism, but the mechanisms controlling p53-associated metabolic activities remain poorly understood.
Matthieu Lacroix, Laetitia K. Linares, Natalia Rueda-Rincon, Katarzyna Bloch, Michela Di Michele, Carlo De Blasio, Caroline Fau, Laurie Gayte, Emilie Blanchet, Aline Mairal, Rita Derua, Fernando Cardona, Diane Beuzelin, Jean-Sebastien Annicotte, Nelly Pirot, Adeline Torro, Francisco J. Tinahones, Florence Bernex, Justine Bertrand-Michel, Dominique Langin, Lluis Fajas, Johannes V. Swinnen, Laurent Le Cam   +22 more
doaj   +1 more source

Protein adduction causes non-mutational inhibition of p53 tumor suppressor

Cell Reports, 2023
Summary: p53 is a key tumor suppressor that is frequently mutated in human tumors. In this study, we investigated how p53 is regulated in precancerous lesions prior to mutations in the p53 gene.
Ravindran Caspa Gokulan, Kodisundaram Paulrasu, Jamal Azfar, Wael El-Rifai, Jianwen Que, Olivier G. Boutaud, Yuguang Ban, Zhen Gao, Monica Garcia Buitrago, Sergey I. Dikalov, Alexander I. Zaika   +10 more
doaj   +1 more source

A New p53 Target Gene, RKIP, Is Essential for DNA Damage-Induced Cellular Senescence and Suppression of ERK Activation

Neoplasia: An International Journal for Oncology Research, 2013
p53, a strong tumor suppressor protein, is known to be involved in cellular senescence, particularly premature cellular senescence. Oncogenic stresses, such as Ras activation, can initiate p53-mediated senescence, whereas activation of the Ras-mitogen ...
Su-Jin Lee, Sun-Hye Lee, Min-Ho Yoon, Bum-Joon Park   +3 more
doaj   +1 more source

Crosstalk between p53 modifiers at PML bodies

Molecular & Cellular Oncology, 2018
Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage.
Sonja Matt, Thomas G Hofmann
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Immunohistochemical analysis of P53 protein in odontogenic cysts

Saudi Dental Journal, 2010
The p53 is a well-known tumor suppressor gene, the mutations of which are closely related to the decreased differentiation of cells. Findings of studies on immunohistochemical P53 expression in odontogenic cysts are controversial.
Essam Taher M.A. Gaballah, Mohamed A. Tawfik   +1 more
doaj   +1 more source

TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities

Genes and Diseases, 2023
Malignant tumor is still a major problem worldwide. During tumorigenesis or tumor development, tumor suppressor p53-binding protein 2 (TP53BP2), also known as apoptosis stimulating protein 2 of p53 (ASPP2), plays a critical role in p53 dependent and ...
Yunfei Huo, Ke Cao, Buxin Kou, Mengyin Chai, Shuangshuang Dou, Dexi Chen, Ying Shi, Xiaoni Liu   +7 more
doaj   +1 more source