Results 21 to 30 of about 233,797 (295)

Zmat3 splices together p53-dependent tumor suppression

Molecular & Cellular Oncology, 2021
The tumor protein p53 (TP53, best known as p53) transcription factor is a critical tumor suppressor, but those p53-inducible genes most important for tumor suppression have remained unclear. Using unbiased RNA interference and CRISPR (Clustered Regularly
Kathryn T. Bieging-Rolett, Laura D. Attardi   +1 more
doaj   +1 more source

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

Nature Communications, 2021
Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell ...
L. Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub   +20 more
doaj   +1 more source

Molecular basis for modulation of the p53 target selectivity by KLF4 [PDF]

, 2012
The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo ...
Brandt, Tobias, Freund, Stefan M. V., Teufel, Daniel P., Townsley, Fiona M., Veprintsev, Dmitry B.   +4 more
core   +15 more sources

Recent Synthetic Approaches towards Small Molecule Reactivators of p53

Biomolecules, 2020
The tumor suppressor protein p53 is often called “the genome guardian” and controls the cell cycle and the integrity of DNA, as well as other important cellular functions.
Jerson L. Silva, Carolina G. S. Lima, Luciana P. Rangel, Giulia D. S. Ferretti, Fernanda P. Pauli, Ruan C. B. Ribeiro, Thais de B. da Silva, Fernando C. da Silva, Vitor F. Ferreira   +8 more
doaj   +1 more source

P53 orchestrates a complex symphony of cellular processes during oncosuppression

Molecular & Cellular Oncology, 2021
We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse ...
Liz J. Valente, Laura D. Attardi
doaj   +1 more source

CHIP Chaperones Wild Type p53 Tumor Suppressor Protein [PDF]

Journal of Biological Chemistry, 2007
Wild type p53 exists in a constant state of equilibrium between wild type and mutant conformation and undergoes conformational changes at elevated temperature. We have demonstrated that the co-chaperone CHIP (carboxyl terminus of Hsp70-interacting protein), which suppressed aggregation of several misfolded substrates and induced the proteasomal ...
Veenu, Tripathi, Amjad, Ali, Rajiv, Bhat, Uttam, Pati   +3 more
openaire   +2 more sources

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

Nature Communications, 2021
The structure of human tumor suppressor p53 in complex with the antiapoptotic protein BCL-xL reveals the basis of the p53–BCL-xL interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.
Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang, Yongheng Chen   +13 more
doaj   +1 more source

Interaction of metallothionein with tumor suppressor p53 protein [PDF]

FEBS Letters, 2006
Previous reports have shown that metallothionein (MT) may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between MT and p53 in cells. The results demonstrate an interaction between MT and p53 can occur in vitro.
Ostrakhovitch, Elena A., Olsson, Per-Erik, Jiang, Sean, Cherian, M. George   +3 more
openaire   +2 more sources

Targeting p53 pathways: mechanisms, structures and advances in therapy

Signal Transduction and Targeted Therapy, 2023
The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles ...
Haolan Wang, Ming Guo, Hudie Wei, Yongheng Chen   +3 more
doaj   +1 more source

Hsp90 Chaperones Wild-type p53 Tumor Suppressor Protein [PDF]

Journal of Biological Chemistry, 2004
Immortalized human fibroblasts were used to investigate the putative interactions of the Hsp90 molecular chaperone with the wild-type p53 tumor suppressor protein. We show that geldanamycin or radicicol, specific inhibitors of Hsp90, diminish specific wild-type p53 binding to the p21 promoter sequence.
Dawid, Walerych, Grzegorz, Kudla, Malgorzata, Gutkowska, Bartosz, Wawrzynow, Lin, Muller, Frank W, King, Aleksandra, Helwak, Joanna, Boros, Alicja, Zylicz, Maciej, Zylicz   +9 more
openaire   +2 more sources