On the involvement of calpains in the degradation of the tumor suppressor protein p53 [PDF]
FEBS Letters, 1997 A crude fraction that contains ubiquitin–protein ligases contains also a proteolytic activity of ∼100 kDa that cleaves p53 to several fragments. The protease does not require ATP and is inhibited in the crude extract by an endogenous ∼250 kDa inhibitor.
Gonen, Hedva +4 more
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p53 regulation by TRP2 is not pervasive in melanoma. [PDF]
PLoS ONE, 2014 p53 is a central tumor suppressor protein and its inhibition is believed to be a prerequisite for cancer development. In approximately 50% of all malignancies this is achieved by inactivating mutations in the p53 gene. However, in several cancer entities,
Roland Houben +9 more
doaj +1 more source
Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane [PDF]
, 2002 p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 ...
Bourdon, J.-C.; id_orcid +9 more
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Characterisation of the p53-Mediated Cellular Responses Evoked in Primary Mouse Cells Following Exposure to Ultraviolet Radiation [PDF]
, 2013 Exposure to ultraviolet (UV) light can cause significant damage to mammalian cells and, although the spectrum of damage produced varies with the wavelength of UV, all parts of the UV spectrum are recognised as being detrimental to human health ...
McFeat, Gillian +5 more
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The Competition of Yin and Yang: Exploring the Role of Wild-Type and Mutant p53 in Tumor Progression
Biomedicines, 2023 The protein p53 is a well-known tumor suppressor that plays a crucial role in preventing cancer development [...]
Bi-He Cai +4 more
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A novel protein with strong homology to the tumor suppressor p53 [PDF]
Oncogene, 1997 The p53 tumor suppressor orchestrates a number of important genes involved in cell-cycle control and apoptosis. Mice deficient for p53 show a high incidence of cancer but are developmentally normal suggesting that compensatory mechanisms exist in embryogenesis and differentiation.
H, Schmale, C, Bamberger
openaire +2 more sources
Clinical Significance of Mutant P53 Protein Expression in Lung Adenocarcinoma
Chinese Journal of Lung Cancer, 2015 Background and objective P53 is a tumor protein that acts as a tumor suppressor. The mutation of P53 may cause loss of tumor suppressor functions and gain of functions favoring cellular proliferation and apoptosis inhibition. The clinical implications of
Chun’an BIAN +5 more
doaj +1 more source
Journal of Cancer Research and Practice, 2014 Background: Overexpression of DNA 5’-cytosine-methyltransferases (DNMTs), which silence genes including tumor suppressor genes, is involved in many cancers. However, the mechanism of DNMT overexpression remains mostly unclear.
Yen-An Tang +5 more
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Immunohistochemical Determination of p53 Protein Overexpression for Predicting p53 Gene Mutations in Hepatocellular Carcinoma: A Meta-Analysis. [PDF]
PLoS ONE, 2016 Whether increased expression of the tumor suppressor protein p53 indicates a p53 gene mutation in hepatocellular carcinoma (HCC) remains unclear.
Jiangbo Liu +5 more
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Long noncoding RNAs: p53's secret weapon in the fight against cancer?
PLoS Biology, 2019 p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor effects of p53.
Emily Dangelmaier +2 more
doaj +1 more source