Results 21 to 30 of about 4,575,740 (255)

Clinical Significance of Mutant P53 Protein Expression in Lung Adenocarcinoma

Chinese Journal of Lung Cancer, 2015
Background and objective P53 is a tumor protein that acts as a tumor suppressor. The mutation of P53 may cause loss of tumor suppressor functions and gain of functions favoring cellular proliferation and apoptosis inhibition. The clinical implications of
Chun’an BIAN, Zhongyou LI, Youtao XU, Jie WANG, Lin XU, Hongbing SHEN   +5 more
doaj   +1 more source

Deregulation of p53 and RB Transcriptional Control Leads to Overexpression of DNA Methyltransferases in Lung Cancer

Journal of Cancer Research and Practice, 2014
Background: Overexpression of DNA 5’-cytosine-methyltransferases (DNMTs), which silence genes including tumor suppressor genes, is involved in many cancers. However, the mechanism of DNMT overexpression remains mostly unclear.
Yen-An Tang, Yo-Ting Tsai, Ruo-Kai Lin, Han-Shui Hsu, Chih-Yi Chen, Yi-Ching Wang   +5 more
doaj   +1 more source

Immunohistochemical Determination of p53 Protein Overexpression for Predicting p53 Gene Mutations in Hepatocellular Carcinoma: A Meta-Analysis. [PDF]

PLoS ONE, 2016
Whether increased expression of the tumor suppressor protein p53 indicates a p53 gene mutation in hepatocellular carcinoma (HCC) remains unclear.
Jiangbo Liu, Wei Li, Miao Deng, Dechun Liu, Qingyong Ma, Xiaoshan Feng   +5 more
doaj   +1 more source

The Competition of Yin and Yang: Exploring the Role of Wild-Type and Mutant p53 in Tumor Progression

Biomedicines, 2023
The protein p53 is a well-known tumor suppressor that plays a crucial role in preventing cancer development [...]
Bi-He Cai, Yu-Te Sung, Chia-Chi Chen, Jei-Fu Shaw, I-Lun Hsin   +4 more
doaj   +1 more source

Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1 [PDF]

, 2012
Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70S6K1 ...
Bernhard Brüne, Milke, Larissa, Kathrin Schulz, Larissa Milke, Heidi R Bokesch, Schulz, Kathrin, Colburn, Nancy H., Blees, Johanna, Schmid, Tobias, Curtis J. Henrich (131182), Tobias Schmid, Kathrin Schulz (131170), Magdalena M. Bajer (131176), Heidi R. Bokesch (131163), Bajer, Magdalena M., Daniela Rübsamen (131166), Johanna S Blees, Henrich, Curtis J., Nancy H. Colburn (131186), James B McMahon, Magdalena M Bajer, James B. McMahon (7677), McMahon, James B., Daniela Rübsamen, Kirk R. Gustafson (131179), Tobias Schmid (131190), Nancy H Colburn, Brüne, Bernhard, Kirk R Gustafson, Rübsamen, Daniela, Bernhard Brüne (131193), Curtis J Henrich, Bokesch, Heidi R., Gustafson, Kirk R., Larissa Milke (131173), Johanna S. Blees (131161)   +35 more
core   +1 more source

Molecular Characterization of ‘p53 Family Network’ in Human Head and Neck Cancer and Anti-EGFR Therapy [PDF]

, 2008
Understanding of p53 family protein (p53, p63 and p73) networks in head and neck squamous cell carcinoma (HNSCC), can positively influence in cancer screening, diagnosis, treatment and prevention.
Sebastian, Sinto
core   +1 more source

Long noncoding RNAs: p53's secret weapon in the fight against cancer?

PLoS Biology, 2019
p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor effects of p53.
Emily Dangelmaier, Sarah B Lazar, Ashish Lal   +2 more
doaj   +1 more source

The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes

Nature Communications, 2021
The p53 tumor suppressor is also a regulator of metabolism, but the mechanisms controlling p53-associated metabolic activities remain poorly understood.
Matthieu Lacroix, Laetitia K. Linares, Natalia Rueda-Rincon, Katarzyna Bloch, Michela Di Michele, Carlo De Blasio, Caroline Fau, Laurie Gayte, Emilie Blanchet, Aline Mairal, Rita Derua, Fernando Cardona, Diane Beuzelin, Jean-Sebastien Annicotte, Nelly Pirot, Adeline Torro, Francisco J. Tinahones, Florence Bernex, Justine Bertrand-Michel, Dominique Langin, Lluis Fajas, Johannes V. Swinnen, Laurent Le Cam   +22 more
doaj   +1 more source

Protein adduction causes non-mutational inhibition of p53 tumor suppressor

Cell Reports, 2023
Summary: p53 is a key tumor suppressor that is frequently mutated in human tumors. In this study, we investigated how p53 is regulated in precancerous lesions prior to mutations in the p53 gene.
Ravindran Caspa Gokulan, Kodisundaram Paulrasu, Jamal Azfar, Wael El-Rifai, Jianwen Que, Olivier G. Boutaud, Yuguang Ban, Zhen Gao, Monica Garcia Buitrago, Sergey I. Dikalov, Alexander I. Zaika   +10 more
doaj   +1 more source

Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3 [PDF]

, 2007
Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and p53-dependent apoptosis.
Underwood, Timothy J., Jay Amin, Amin, Jay, Blaydes, Jeremy P., Timothy J. Underwood, Lillycrop, Karen A., Jeremy P. Blaydes, Karen A. Lillycrop   +7 more
core   +1 more source