p53 regulation by TRP2 is not pervasive in melanoma. [PDF]
PLoS ONE, 2014 p53 is a central tumor suppressor protein and its inhibition is believed to be a prerequisite for cancer development. In approximately 50% of all malignancies this is achieved by inactivating mutations in the p53 gene. However, in several cancer entities,
Roland Houben +9 more
doaj +1 more source
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]
, 2012 Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone +2 more
core +2 more sources
Tumor suppressor p53 cross-talks with TRIM family proteins
Genes & Diseases, 2021 p53 is a key tumor suppressor. As a transcription factor, p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor suppression.
Juan Liu +4 more
openaire +3 more sources
The Competition of Yin and Yang: Exploring the Role of Wild-Type and Mutant p53 in Tumor Progression
Biomedicines, 2023 The protein p53 is a well-known tumor suppressor that plays a crucial role in preventing cancer development [...]
Bi-He Cai +4 more
doaj +1 more source
Clinical Significance of Mutant P53 Protein Expression in Lung Adenocarcinoma
Chinese Journal of Lung Cancer, 2015 Background and objective P53 is a tumor protein that acts as a tumor suppressor. The mutation of P53 may cause loss of tumor suppressor functions and gain of functions favoring cellular proliferation and apoptosis inhibition. The clinical implications of
Chun’an BIAN +5 more
doaj +1 more source
Journal of Cancer Research and Practice, 2014 Background: Overexpression of DNA 5’-cytosine-methyltransferases (DNMTs), which silence genes including tumor suppressor genes, is involved in many cancers. However, the mechanism of DNMT overexpression remains mostly unclear.
Yen-An Tang +5 more
doaj +1 more source
Immunohistochemical Determination of p53 Protein Overexpression for Predicting p53 Gene Mutations in Hepatocellular Carcinoma: A Meta-Analysis. [PDF]
PLoS ONE, 2016 Whether increased expression of the tumor suppressor protein p53 indicates a p53 gene mutation in hepatocellular carcinoma (HCC) remains unclear.
Jiangbo Liu +5 more
doaj +1 more source
Tumor Suppressor Protein p53 Regulates Megakaryocytic Polyploidization and Apoptosis [PDF]
Journal of Biological Chemistry, 2008 The molecular mechanisms underlying differentiation of hematopoietic stem cells into megakaryocytes are poorly understood. Tumor suppressor protein p53 can act as a transcription factor affecting both cell cycle control and apoptosis, and we have previously shown that p53 is activated during terminal megakaryocytic (Mk) differentiation of the CHRF-288 ...
Peter G, Fuhrken +4 more
openaire +2 more sources
The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration. [PDF]
, 2015 The control of proliferation and differentiation by tumor suppressor genes suggests that evolution of divergent tumor suppressor repertoires could influence species regenerative capacity.
Ahituv, Nadav +3 more
core +1 more source
Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer [PDF]
, 2018 Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer.
Fatica, Alessandro, Morlando, Mariangela
core +5 more sources