Results 41 to 50 of about 154,391 (307)

Immunohistochemical analysis of P53 protein in odontogenic cysts

Saudi Dental Journal, 2010
The p53 is a well-known tumor suppressor gene, the mutations of which are closely related to the decreased differentiation of cells. Findings of studies on immunohistochemical P53 expression in odontogenic cysts are controversial.
Essam Taher M.A. Gaballah, Mohamed A. Tawfik   +1 more
doaj   +1 more source

TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities

Genes and Diseases, 2023
Malignant tumor is still a major problem worldwide. During tumorigenesis or tumor development, tumor suppressor p53-binding protein 2 (TP53BP2), also known as apoptosis stimulating protein 2 of p53 (ASPP2), plays a critical role in p53 dependent and ...
Yunfei Huo, Ke Cao, Buxin Kou, Mengyin Chai, Shuangshuang Dou, Dexi Chen, Ying Shi, Xiaoni Liu   +7 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Urokinase Expression by Tumor Suppressor Protein p53 [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2008
Abstract Lung carcinoma (H1299) cells deficient in p53 (p53−/−) express large amounts of urokinase-type plasminogen activator (uPA) protein and uPA mRNA, and exhibit slower degradation of uPA mRNA than that of p53-expressing nonmalignant Beas2B human airway epithelial cells.
Praveenkumar Shetty, Thirunavukkarasu Velusamy, Yashodhar P. Bhandary, Rashmi S. Shetty, Ming-Cheh Liu, Sreerama Shetty   +5 more
openaire   +1 more source

Mutant p53 and ETS2, a tale of reciprocity

Frontiers in Oncology, 2016
TP53 is one of the most frequently inactivated tumor suppressor genes in human cancer. However, unlike other tumor suppressor genes whose expression is lost, TP53 is usually inactivated as a result of a single nucleotide change within the coding region.
Luis Alfonso Martinez
doaj   +1 more source

Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53 [PDF]

, 2012
Bovine papillomavirus type 1 infects not only cattle but also equids and is a causative factor in the pathogenesis of commonly occurring equine sarcoid tumours.
Finlay, M., Morgan Iain M, M Campo, Margaret Finlay, Campo M, Finlay Margaret, Yuan ZhengQiang, Lubna Nasir, Morgan, I.M., Campo, M., ZhengQiang Yuan, Iain M Morgan, Nasir Lubna, Yuan, Z., Nasir, L.   +14 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Novel p53 therapies for head and neck cancer

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2016
Inactivation of the tumor suppressor p53 is the predominant pathogenetic event in head and neck squamous cell carcinoma (HNSCC). The p53 pathway in HNSCC can be compromised through multiple mechanisms including gene mutations, hyperactivation of ...
Mario R. Castellanos, Quintin Pan
doaj   +1 more source

Progress of TP53 Family Gene TP73 and Tumorigenesis

Zhongliu Fangzhi Yanjiu, 2021
P73 protein is one of the main members of p53 protein family, and its coding gene TP73 is highly homologous to TP53 gene. On one hand, similar to p53, p73 protein is involved in all aspects of cell life.
XU Jie, HAO Mu
doaj   +1 more source