Results 61 to 70 of about 154,391 (307)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Protein methylation: a new mechanism of p53 tumor suppressor regulation.

Histology and histopathology, 2008
The tumor suppressor p53 is the most frequently inactivated gene in human cancers. The p53 protein functions as a sequence-specific transcription factor to regulate key cellular processes, including cell-cycle arrest, DNA repair, apoptosis, and senescence in response to stress signals.
Scoumanne, A., Chen, X.
openaire   +3 more sources

Tumor suppressor protein p53 binds preferentially to supercoiled DNA [PDF]

Oncogene, 1997
Wild type human tumor suppressor protein p53 (expressed in insect cells) binds strongly to negatively supercoiled (sc) plasmid DNA at a native superhelix density, as evidenced by electrophoretic retardation of scDNA in agarose gels and imaging by scanning force microscopy (SFM).
Palecek, E., Vlk, D., Stankova, V., Brazda, V., Vojtesek, B., Hupp, T., Schaper, A., Jovin, T.   +7 more
openaire   +3 more sources

Immunohistochemistry Assessment of P53 Protein in Basal Cell Carcinoma

Iranian Journal of Allergy, Asthma and Immunology, 2005
The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or else induce apoptosis.
Reza Ghaderi Fatemeh Haghighi
doaj  

Crucial role of TSC-22 in preventing the proteasomal degradation of p53 in cervical cancer. [PDF]

PLoS ONE, 2012
The p53 tumor suppressor function can be compromised in many tumors by the cellular antagonist HDM2 and human papillomavirus oncogene E6 that induce p53 degradation. Restoration of p53 activity has strong therapeutic potential. Here, we identified TSC-22
Cheol-Hee Yoon, Seung Bae Rho, Seong-Tae Kim, Seongho Kho, Junsoo Park, Ik-Soon Jang, Seonock Woo, Sung Soon Kim, Je-Ho Lee, Seung-Hoon Lee   +9 more
doaj   +1 more source

Comparison of p53 Protein Expression between Oral Squamous Cell Carcinoma and Verrucous Carcinoma

RUHS Journal of Health Sciences, 2023
Introduction: Deletion or mutation of tumor suppressor genes plays a significant role in cancer development. Mutation of the p53 tumor suppressor gene is the most common genetic alteration associated with oral cancer. The aim of this study was to compare
Anil Singh; Shikha Saxena; Safia Siddiqui; Ruchita Bali; Priyanka Singh
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Hsp90 Chaperones Wild-type p53 Tumor Suppressor Protein [PDF]

Journal of Biological Chemistry, 2004
Immortalized human fibroblasts were used to investigate the putative interactions of the Hsp90 molecular chaperone with the wild-type p53 tumor suppressor protein. We show that geldanamycin or radicicol, specific inhibitors of Hsp90, diminish specific wild-type p53 binding to the p21 promoter sequence.
Dawid, Walerych, Grzegorz, Kudla, Malgorzata, Gutkowska, Bartosz, Wawrzynow, Lin, Muller, Frank W, King, Aleksandra, Helwak, Joanna, Boros, Alicja, Zylicz, Maciej, Zylicz   +9 more
openaire   +2 more sources

New therapeutic strategies to treat human cancers expressing mutant p53 proteins

Journal of Experimental & Clinical Cancer Research, 2018
The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis. The TP53 is the most frequently inactivated gene in human cancers.
Giovanni Blandino, Silvia Di Agostino
doaj   +1 more source

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]

, 2013
The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Knight, J.R.P., Knight, J. R. P., Knight, John R.P.; id_orcid, Milner, J., Allison, Simon J., Milner, Jo   +5 more
core   +1 more source