Results 51 to 60 of about 148,781 (262)

Breast Cancer Therapy by Small-Molecule Reactivation of Mutant p53

Current Oncology
Tumor suppressor p53 is essential for maintaining DNA stability and preventing cancer. Under normal conditions, the p53 protein is either degraded or bound to a negative regulator, rendering it inactive, but when DNA damage occurs, p53 is activated ...
Simon H. Slight, Salman M. Hyder
doaj   +1 more source

New therapeutic strategies to treat human cancers expressing mutant p53 proteins

Journal of Experimental & Clinical Cancer Research, 2018
The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis. The TP53 is the most frequently inactivated gene in human cancers.
Giovanni Blandino, Silvia Di Agostino
doaj   +1 more source

Hsp90 Chaperones Wild-type p53 Tumor Suppressor Protein [PDF]

Journal of Biological Chemistry, 2004
Immortalized human fibroblasts were used to investigate the putative interactions of the Hsp90 molecular chaperone with the wild-type p53 tumor suppressor protein. We show that geldanamycin or radicicol, specific inhibitors of Hsp90, diminish specific wild-type p53 binding to the p21 promoter sequence.
Walerych, Dawid, Kudla, Grzegorz, Małgorzata Gutkowska-Stronkowska, Wawrzynow, Bartosz, Muller, Lin, King, Frank, Helwak, Aleksandra, Boros, Joanna, Zylicz, Alicja, Zylicz, Maciej   +9 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The regulation of the function of the tumor suppressor protein p53 [PDF]

Biochemistry and Molecular Biology Education, 2003
AbstractTerms to be familiar with before you start to solve the test: Tumor suppressor proteins; p53 protein; p53‐positive and p53‐negative tumors; transcription factors; protein phosphorylation; retinoblastoma protein; Go phase; apoptosis; chaperone; transfection; expression plasmid; cDNA; papillomavirus; Western blot analysis; γ‐irradiation; mitotic ...
openaire   +1 more source

Tumor Suppressor Protein p53 Regulates Megakaryocytic Polyploidization and Apoptosis [PDF]

Journal of Biological Chemistry, 2008
The molecular mechanisms underlying differentiation of hematopoietic stem cells into megakaryocytes are poorly understood. Tumor suppressor protein p53 can act as a transcription factor affecting both cell cycle control and apoptosis, and we have previously shown that p53 is activated during terminal megakaryocytic (Mk) differentiation of the CHRF-288 ...
Peter G, Fuhrken, Pani A, Apostolidis, Stephan, Lindsey, William M, Miller, Eleftherios T, Papoutsakis   +4 more
openaire   +2 more sources

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

p53 Genetics and Biology in Lung Carcinomas: Insights, Implications and Clinical Applications

Biomedicines
The TP53 gene is renowned as a tumor suppressor, playing a pivotal role in overseeing the cell cycle, apoptosis, and maintaining genomic stability. Dysregulation of p53 often contributes to the initiation and progression of various cancers, including ...
Dixan A. Benitez, Guadalupe Cumplido-Laso, Marcos Olivera-Gómez, Nuria Del Valle-Del Pino, Alba Díaz-Pizarro, Sonia Mulero-Navarro, Angel Román-García, Jose Maria Carvajal-Gonzalez   +7 more
doaj   +1 more source

Correlation of cell cycle regulatory proteins (p53 and p16ink4a) and bcl-2 oncoprotein with mitotic index and thickness of primary cutaneous malignant melanoma

Biomolecules & Biomedicine, 2010
The purpose of the study was to determine the frequency of expression p53 and p16INK4a proteins and bcl2- oncoprotein in malignant skin melanoma and to determine their correlation with the proliferative index and tumor thickness.
Miloš Kostov, Žaklina Mijović, Dragan Mihailović, Snežana Cerović, Miroslav Stojanović, Marija Jelić   +5 more
doaj   +1 more source