Results 81 to 90 of about 4,575,740 (255)

Gene mutations and expression in breast cancer [PDF]

, 2000
Bibliography: leaves 163-190.Breast cancer is the most common cause of death amongst women, with the incidence of the disease varying between countries. Like all other cancers, breast cancer is a multigenic disorder with mutations in oncogenes and tumour
Donninger, Howard
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The protein kinase DYRK1B is a p53 target gene and functions as a negative feedback regulator of the transcription factor RFX7

Cell Death and Disease
The tumor suppressor protein p53 orchestrates cellular responses to stress by regulating the transcription of target genes involved in processes such as cell cycle control, DNA damage repair and apoptosis.
Gerrit Wilms, Katharina Schwandt, Stefan Düsterhöft, Philip Helmich, Justyna Wozniak, Florian Kraft, Sebastian Kallabis, Felix Meissner, Walter Becker   +8 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Frontiers in Oncology, 2013
Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs.
Ming-Fu eChiang, Pei-Yi eChou, Wan-Jen eWang, Chun-I eSze, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang   +7 more
doaj   +1 more source

Crosstalk between c-Jun and TAp73alpha/beta contributes to the apoptosis–survival balance [PDF]

, 2011
The p53-family member p73 plays a role in various cellular signaling pathways during development and growth control and it can have tumor suppressor properties. Several isoforms of p73 exist with considerable differences in their function.
Simon J. van Heeringen, Smeenk, L., Smeenk, Leonie, Hartmann, Marianne, Eva Janssen-Megens, Lohrum, Marion, Koeppel, M., Heeringen, S.J. van, Hendrik G. Stunnenberg, Daniela Kramer, Hartmann, M., Lohrum, M., Stunnenberg, H.G., Stunnenberg, Hendrik G., Max Koeppel, Kramer, D., Leonie Smeenk, Koeppel, Max, Kramer, Daniela, Janssen-Megens, Eva, Heeringen, Simon J. van, Janssen-Megens, E.M., Marion Lohrum, Marianne Hartmann   +23 more
core   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

p53: from understanding its structure to advances in therapeutic targeting

Signal Transduction and Targeted Therapy
The tumor suppressor gene TP53 is the most frequently mutated gene in human cancers and has been a popular area of research in the field of oncology.
Wenhua Wang, Xia Liu, Hengqi Liu, Hassan Abolhassani, Han Yan, Huilai Zhang, Xianhuo Wang   +6 more
doaj   +1 more source

Selective inhibitors of nuclear export for the treatment of non-Hodgkin’s lymphomas

Haematologica, 2013
The nuclear export protein chromosome maintenance region 1, found to be elevated in non-Hodgkin’s lymphomas, controls localization of critical tumor suppressor proteins.
Asfar S. Azmi, Ayad Al-Katib, Amro Aboukameel, Dilara McCauley, Michael Kauffman, Sharon Shacham, Ramzi M. Mohammad   +6 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source