Results 101 to 110 of about 4,575,740 (255)

Structural assessment of the full-length wild-type tumor suppressor protein p53 by mass spectrometry-guided computational modeling. [PDF]

Sci Rep, 2023
Di Ianni A, Tüting C, Kipping M, Ihling CH, Köppen J, Iacobucci C, Arlt C, Kastritis PL, Sinz A.   +8 more
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

OTUD4 suppresses colorectal cancer progression through deubiquitinating p53

Discover Oncology
Colorectal cancer (CRC) represents a global health burden as the third most commonly diagnosed malignancy and the second leading cause of cancer-related mortality.
Xianyue Bu, Yingxu Wang, Jinzhen Pan, Shuai Li, Penghao Li, Bing Zheng   +5 more
doaj   +1 more source

The Activation of the Tumor Suppressor Protein p53 by Acriflavine Leads to Mitochondrial Dysfunction and Improves the Radiosensitivity of Colon Cancer Cells. [PDF]

J Immunol Res, 2022
Lin C, Chen X, Qiu H, Li B, Guo M.
europepmc   +1 more source

MAGE-A cancer/testis antigens inhibit MDM2 ubiquitylation function and promote increased levels of MDM4 [PDF]

, 2015
Melanoma antigen A (MAGE-A) proteins comprise a structurally and biochemically similar sub-family of Cancer/Testis antigens that are expressed in many cancer types and are thought to contribute actively to malignancy.
Susan E. Bray (264528), Thompson, Alastair M., Hourihan John, Quinlan Philip R., Philip R. Quinlan (743773), Thompson Alastair M., Meek, David W., Alastair M. Thompson (743775), Meek, David W, Marcar Lynnette, Lee B. Jordan (743774), Ihrig Bianca, David W Meek, Ted R. Hupp (141798), Hupp Ted R., Ihrig, Bianca, Hourihan, John, Meek David W., Bray Susan E., Thompson, Alastair M, Quinlan, Philip R., Susan E Bray, Lynnette Marcar (743770), Hupp, Ted R., John Hourihan, Philip R Quinlan, Jordan, Lee B., Bray, Susan E, Ted R Hupp, Lynnette Marcar, Quinlan, Philip R, David W. Meek (743776), Jordan Lee B., Alastair M Thompson, Marcar, Lynnette, Bianca Ihrig, John Hourihan (743772), Hupp, Ted R, Bray, Susan E., Lee B Jordan, Bianca Ihrig (743771), Jordan, Lee B   +41 more
core   +2 more sources

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance

Cell Death and Disease
Several studies have shown that Parkinson’s disease causative gene products, including α-synuclein (α-syn), display tight links with the tumor suppressor p53.
Eric Duplan, Aurore Bernardin, Thomas Goiran, Nathalie Leroudier, Mathew Casimiro, Richard Pestell, Shinya Tanaka, Celine Malleval, Jerome Honnorat, Ahmed Idbaih, Lucie Martin, Hélène Castel, Frédéric Checler, Cristine Alves da Costa   +13 more
doaj   +1 more source

Therapeutic targeting of TP53 nonsense mutations in cancer

Upsala Journal of Medical Sciences
Mutations in the TP53 tumor suppressor gene occur with high prevalence in a wide range of human tumors. A significant fraction of these mutations (around 10%) are nonsense mutations, creating a premature termination codon (PTC) that leads to the ...
Charlotte Strandgren, Klas G. Wiman
doaj   +1 more source

Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer-A Promising Signaling Network for Therapeutic Interventions. [PDF]

Cancers (Basel), 2021
Güllülü Ö, Hehlgans S, Rödel C, Fokas E, Rödel F.   +4 more
europepmc   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source