Results 21 to 30 of about 2,989,296 (301)
Molecular Cancer, 2019 Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg ...
Ju-Ha Kim +5 more
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Neurobiology of Disease, 2001 The neurofibromatosis 2 (NF2) tumor suppressor belongs to the Protein 4.1 family of molecules that link the actin cytoskeleton to cell surface glycoproteins.
David H. Gutmann +3 more
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S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study
Translational Oncology, 2020 Novel coronavirus disease 2019 (COVID-19) is the biggest threat to human being globally. The first case was identified in a patient with flu symptoms along with severe acute respiratory syndrome in Wuhan, China in December 2019 and now it has spread in ...
Nishant Singh, Anuradha Bharara Singh
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PML surfs into HIPPO tumor suppressor pathway
Frontiers in Oncology, 2013 Growth arrest, inhibition of cell proliferation, apoptosis, senescence and differentiation are the most characterized effects of a given tumor suppressor response.
Sabrina eStrano +5 more
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Transcriptional responses of tumor cell lines to interferon-alpha [PDF]
, 2013 Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
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Expression of p53, p16 and Ki67 proteins in ductal adenocarcinoma of the pancreatic head and their relation with survival and cell differentiation [PDF]
Einstein (São Paulo), 2010 Objective: To determine the expression of p53, p16 and Ki-67 and its relevance in survival and cell differentiation. Methods: Fifteen duodenopancreatectomized patients were included. Immunohistochemical expression of p53, p16 and Ki-67 was determined in
Mário Benjamin Goitia-Durán +5 more
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Mutant p53 : One, No One and One Hundred Thousand
Frontiers in Oncology, 2015 Encoded by the mutated variants of the TP53 tumor suppressor gene, mutant p53 proteins are getting an increased experimental support as active oncoproteins promoting tumor growth and metastasis.
Dawid eWalerych +4 more
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Hypothetical protein predicted to be tumor suppressor: a protein functional analysis [PDF]
Genomics & Informatics, 2021 Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and function of the biologically important hypothetical ...
Md. Abdul Kader +5 more
openaire +2 more sources
The tumor suppressor protein p150Sal2 in carcinogenesis
Tumor Biology, 2015 The transcription factor p150(Sal2), the product of the SALL2 gene, was first identified as a binding target of the oncogenic mouse polyomavirus T antigen. However, mouse polyomavirus is not the only oncogenic virus that targets p150(Sal2); the human papillomavirus E6 protein also targets this cellular protein in order to overcome p150(Sal2)-mediated ...
Chang Kyoo, Sung, Hyungshin, Yim
openaire +2 more sources
H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers
eLife, 2018 Expression of histone H3.3K27M mutant proteins in human diffuse intrinsic pontine glioma (DIPG) results in a global reduction of tri-methylation of H3K27 (H3K27me3), and paradoxically, H3K27me3 peaks remain at hundreds of genomic loci, a dichotomous ...
Dong Fang +7 more
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