Results 21 to 30 of about 308,123 (261)
Hypothetical protein predicted to be tumor suppressor: a protein functional analysis [PDF]
Genomics & Informatics, 2021 Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and function of the biologically important hypothetical ...
Md. Abdul Kader +5 more
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H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers
eLife, 2018 Expression of histone H3.3K27M mutant proteins in human diffuse intrinsic pontine glioma (DIPG) results in a global reduction of tri-methylation of H3K27 (H3K27me3), and paradoxically, H3K27me3 peaks remain at hundreds of genomic loci, a dichotomous ...
Dong Fang +7 more
doaj +1 more source
The tumor suppressor protein p150Sal2 in carcinogenesis
Tumor Biology, 2015 The transcription factor p150(Sal2), the product of the SALL2 gene, was first identified as a binding target of the oncogenic mouse polyomavirus T antigen. However, mouse polyomavirus is not the only oncogenic virus that targets p150(Sal2); the human papillomavirus E6 protein also targets this cellular protein in order to overcome p150(Sal2)-mediated ...
Chang Kyoo, Sung, Hyungshin, Yim
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A neuronal function of the tumor suppressor protein merlin [PDF]
Acta Neuropathologica Communications, 2014 Mutagenic loss of the NF2 tumor suppressor gene encoded protein merlin is known to provoke the hereditary neoplasia syndrome, Neurofibromatosis type 2 (NF2). In addition to glial cell-derived tumors in the PNS and CNS, disease-related lesions also affect the skin and the eyes.
Schulz, Alexander +2 more
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Molecular Oncology, 2011 Aneuploidy, often preceded by tetraploidy, is one of the hallmarks of solid tumors. Indeed, both aneuploidy and tetraploidy are oncogenic occurrences that are sufficient to drive neoplastic transformation and cancer progression.
Yael Aylon, Moshe Oren
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Cells, 2022 Tumor suppressor WWOX inhibits cancer growth and retards Alzheimer’s disease (AD) progression. Supporting evidence shows that the more strongly WWOX binds intracellular protein partners, the weaker is cancer cell growth in vivo.
Tsung-Yun Liu +7 more
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2018 DOI: 10.3969/j.issn.1672-6731.2018.05 ...
Xuan CHEN, Xian-hui REN, Yan-chun DENG
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The Role of SOCS in the Development of Tumors
Chinese Journal of Lung Cancer, 2016 Suppressor of cytokine signaling (SOCS) family proteins are a group of negative regulatory factors that plays important roles in the negative regulation of cytokine responses by terminating the activation of the JAK-STAT and other signaling pathways. The
Chunlai LIU, Hongyu LIU, Jun CHEN
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Interaction of metallothionein with tumor suppressor p53 protein [PDF]
FEBS Letters, 2006 Previous reports have shown that metallothionein (MT) may modulate p53 activity through zinc exchange. However, little is known on a direct interaction between MT and p53 in cells. The results demonstrate an interaction between MT and p53 can occur in vitro.
Ostrakhovitch, Elena A. +3 more
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Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source