Results 1 to 10 of about 18,502 (170)

Tuberous Sclerosis Complex Proteins 1 and 2 Control Serum-Dependent Translation in a TOP-Dependent and -Independent Manner [PDF]

Molecular and Cellular Biology, 2007
The tuberous sclerosis complex (TSC) proteins TSC1 and TSC2 regulate protein translation by inhibiting the serine/threonine kinase mTORC1 (for mammalian target of rapamycin complex 1). However, how TSC1 and TSC2 control overall protein synthesis and the translation of specific mRNAs in response to different mitogenic and nutritional stimuli is largely ...
Benoit, Bilanges, Rhoda, Argonza-Barrett, Marina, Kolesnichenko, Christina, Skinner, Manoj, Nair, Michelle, Chen, David, Stokoe   +6 more
openaire   +4 more sources

Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC) [PDF]

Molecular & Cellular Proteomics, 2016
Many biological processes involve the mechanistic/mammalian target of rapamycin complex 1 (mTORC1). Thus, the challenge of deciphering mTORC1-mediated functions during normal and pathological states in the central nervous system is challenging. Because mTORC1 is at the core of translation, we have investigated mTORC1 function in global and regional ...
Farr, Niere, Sanjeev, Namjoshi, Ehwang, Song, Geoffrey A, Dilly, Grant, Schoenhard, Boris V, Zemelman, Yehia, Mechref, Kimberly F, Raab-Graham   +7 more
openaire   +3 more sources

Deficiency in pulmonary surfactant proteins in mice with fatty acid binding protein 4‐Cre‐mediated knockout of the tuberous sclerosis complex 1 gene [PDF]

Experimental Physiology, 2012
New findings What is the central question of this study?Does tuberous sclerosis complex 1–mammalian target of rapamycin (mTOR) signalling regulate the synthesis of surfactant proteins A and B and, if so, can this contribute to the postnatal death of Fabp4‐Tsc1cKO mice?
Xiang, Xinxin, Yuan, Fang, Zhao, Jing, Li, Ziru, Wang, Xian, Guan, Youfei, Tang, Chaoshu, Sun, Guang, Li, Yin, Zhang, Weizhen   +9 more
openaire   +5 more sources

Mammalian Target of Rapamycin Complex 1 (mTORC1) Enhances Bortezomib-induced Death in Tuberous Sclerosis Complex (TSC)-null Cells by a c-MYC-dependent Induction of the Unfolded Protein Response [PDF]

Journal of Biological Chemistry, 2013
Many factors, including duration and intensity of the unfolded protein response (UPR), dictate whether cells will adapt to endoplasmic reticulum stress or undergo apoptosis. In tuberous sclerosis (TSC), elevation of mammalian target of rapamycin complex 1 (mTORC1) activity has been proposed to compound the induction of UPR transcription factors ATF4 ...
Justin T, Babcock, Hoa B, Nguyen, Yujun, He, Jeremiah W, Hendricks, Ronald C, Wek, Lawrence A, Quilliam   +5 more
openaire   +4 more sources

Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure [PDF]

Journal of Vascular Surgery, 2013
Chronic renal failure (CRF) is associated with increased cardiovascular mortality, and medial vascular smooth muscle cell (VSMC) hypertrophy, proliferation, and calcification play a pivotal role in uremic vasculopathy. Glucose transporter-1 (GLUT1) facilitates the transport of glucose into VSMCs, and GLUT1 overexpression associated with high glucose ...
Lin, Chih-Yuan, Hsu, Shih-Che, Lee, Herng-Sheng, Lin, Shih-Hua, Tsai, Chien-Sung, Huang, Shih-Ming, Shih, Chun-Che, Hsu, Yu-Juei   +7 more
openaire   +3 more sources

Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1α production in sporadic clear-cell renal cell carcinoma

Experimental and Molecular Pathology, 2016
Alterations in von Hippel-Lindau gene (VHL) do not determine deregulation of hypoxia-inducible factors (HIFs) in clear-cell renal carcinoma (ccRCC). Their effects on tuberous sclerosis proteins (TSC1/2) and heat shock protein 90 (Hsp90) expressions in sporadic ccRCC are unknown.
Svetozar S, Damjanovic, Bojana B, Ilic, Bojana B, Beleslin Cokic, Jadranka A, Antic, Jovana Z, Bankovic, Ivana T, Milicevic, Gordana S, Rodic, Dusan S, Ilic, Vera N, Todorovic, Nela, Puskas, Cane D, Tulic   +10 more
openaire   +3 more sources

Mammalian target of rapamycin complex 1 (mTORC1); tuberous sclerosis complex tumor suppressors 1 and 2 (TSC1 and TSC2); unfolded protein response (UPR) [PDF]

Science-Business eXchange, 2008
openaire   +3 more sources

Tuberous Sclerosis Complex in a 17-month-old: A Case Report

Journal of Nepal Medical Association, 2023
Tuberous sclerosis complex is a rare autosomal dominant genetic disorder that affects multiple organ systems, primarily affecting the central nervous system. It develops with a pathogenic mutation in tumour suppressor genes i.e.
Sarjan K.C., Anjana Bohaju, Sunil Raja Manandhar, Anup Shrestha, Erika Aryal, Pradeep Maharjan   +5 more
doaj   +1 more source

The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back

Frontiers in Cell and Developmental Biology, 2021
The tuberous sclerosis protein complex (TSC complex) is a key integrator of metabolic signals and cellular stress. In response to nutrient shortage and stresses, the TSC complex inhibits the mechanistic target of rapamycin complex 1 (mTORC1) at the ...
Ulrike Rehbein, Mirja Tamara Prentzell, Mirja Tamara Prentzell, Marti Cadena Sandoval, Marti Cadena Sandoval, Alexander Martin Heberle, Alexander Martin Heberle, Elizabeth P. Henske, Christiane A. Opitz, Christiane A. Opitz, Kathrin Thedieck, Kathrin Thedieck, Kathrin Thedieck   +12 more
doaj   +1 more source

Genetic and Environmental Contributions to Autism Spectrum Disorder Through Mechanistic Target of Rapamycin

Biological Psychiatry Global Open Science, 2022
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects an individual’s reciprocal social interaction and communication ability.
Atsushi Sato, Kazutaka Ikeda
doaj   +1 more source